Institutt for klinisk medisin: Nye registreringer
Viser treff 461-480 av 1930
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Cervical spine surgery in the Northern Norway Regional Health Authority area in 2014-18
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)<p>BAKGRUNN - Kunnskap om variasjon i behandlingsrater er nødvendig for å vurdere om tilgangen til helsetjenester er likeverdig. Formålet med denne studien var å undersøke rater for kirurgisk behandling av degenerative nakkelidelser i Norge og Helse Nord, samt egendekningen i Helse Nord, og å vurdere aktiviteten i regionen. <p>MATERIALE OG METODE - Vi inkluderte operasjoner registrert i Norsk ... -
A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-23)Abstract Background Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specifc hip MRI scoring system has not been validated.<p> <p>Objective To test the intra- and interobserver agreement of several MRI markers for active and chronic hip changes in children and young adults with JIA and to examine the precision of ... -
Improving the Applicability of AI for Psychiatric Applications through Human-in-the-loop Methodologies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-26)Objectives: Machine learning (ML) and natural language processing have great potential to improve effciency and accuracy in diagnosis, treatment recommendations, predictive interventions, and scarce resource allocation within psychiatry. Researchers often conceptualize such an approach as operating in isolation without much need for human involvement, yet it remains crucial to harness human-inthe-loop ... -
Risk of obstetric anal sphincter injury associated with female genital mutilation/cutting and timing of deinfibulation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)Introduction: A greater risk of obstetric anal sphincter injury has been reported among African migrants in several host countries compared with the general population. To what degree female genital mutilation/cutting affects this risk is not clear. In infibulated women, deinfibulation prevents anal sphincter injury. Whether the timing of deinfibulation affects the risk, is unknown. This study ... -
Introducing Lightweight IT – A Way to Build Flexibility for Healthcare Organizations?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)The paper addresses socio technical relations of implementing a lightweight IT app in Norway. The focus is on how such technology will influence the possibilities for an organization connected to a large-scale heavyweight IT infrastructure to provide more rapid changes in line with healthcare worker’s needs. The research question is therefore: How can lightweight IT support rapid organizational ... -
Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)Background Testosterone is the standard treatment for male hypogonadism, but there is uncertainty about its cardiovascular safety due to inconsistent findings. We aimed to provide the most extensive individual participant dataset (IPD) of testosterone trials available, to analyse subtypes of all cardiovascular events observed during treatment, and to investigate the effect of incorporating data ... -
Alterations in genetically modified crops assessed by omics studies: Systematic review and meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-04)Background International agreements and domestic legislation regulate genetically modified (GM) crops for environmental release, recognizing that genetic engineering could result in unintended genotypic and phenotypic effects. In that context, omics technologies, which allow comprehensive characterization of the molecular profile of GM crops at all levels, may be used to assess alterations or effects ... -
Geographical variation in orthopedic procedures in Norway: Cross-sectional population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-14)Background: Standardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are associated with geographical variation in surgery rates for six common orthopedic procedures.<p> <p>Methods: The present study is a cross-sectional population-based study of hospital ... -
The risk factors for radial artery and saphenous vein graft occlusion are different
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-02)Objectives. To determine risk factors for radial artery and saphenous vein graft occlusion during long-term follow-up after coronary artery bypass grafting (CABG). Methods: From a cohort of 119 patients who had received a radial artery graft, 76 – of whom 55 also had at least one saphenous vein graft – underwent a preplanned direct angiography and anthropometric, biochemical, and endothelial ... -
History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ... -
Normalization of gene expression data revisited: the three viewpoints of the transcriptome in human skeletal muscle undergoing load-induced hypertrophy and why they matter
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-18)Background - The biological relevance and accuracy of gene expression data depend on the adequacy of data normalization. This is both due to its role in resolving and accounting for technical variation and errors, and its defining role in shaping the viewpoint of biological interpretations. Still, the choice of the normalization method is often not explicitly motivated although this choice may be ... -
Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-09)Introduction: Victims of accidental hypothermia in hypothermic cardiac arrest (HCA) may survive with favorable neurologic outcome if early and continuous prehospital cardiopulmonary resuscitation (CPR) is started and continued during evacuation and transport. The efficacy of cerebral autoregulation during hypothermic CPR is largely unknown and is aim of the present experiment.<p> <p>Methods: ... -
The relationships between use of alcohol, tobacco and coffee in adolescence and mood disorders in adulthood
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)Introduction: Alcohol, tobacco and coffee are commonly used substances and use in adolescence has previously been linked to mood disorders. However, few large prospective studies have investigated adolescent use in relation to mental health outcomes in adulthood. The main aim of this study was to examine the prospective associations between alcohol use, cigarette smoking and coffee consumption ... -
Target Values and Daytime Variation of Bone Turnover Markers in Monitoring Osteoporosis Treatment After Fractures
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-22)The serum bone turnover markers (BTM) procollagen type 1 N-terminal propeptide (P1NP) and C-terminal cross-linking telopeptide of type 1 collagen (CTX) are recommended for monitoring adherence and response of antiresorptive drugs (ARD). BTM are elevated about 1 year after fracture and therefore BTM target values are most convenient in ARD treatment follow-up of fracture patients. In this prospective ... -
Norwegian Cross-Cultural Adaptation of the Social and Communities Opportunities Profile-Mini for Persons with Concurrent Mental Health and Substance Use Disorders.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)Persons with concurrent mental health and substance use disorders often do not participate actively in society and remain marginalized. The promotion of social inclusion is important for the care of persons with concurrent disorders. To measure social inclusion, the Social and Communities Opportunities Profile (SCOPE) was developed, followed by its mini version for English-speaking people in Singapore. ... -
Surgery for degenerative cervical myelopathy in the elderly: a nationwide registry-based observational study with patient-reported outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)Background - The aim of this study was to investigate whether clinical outcomes in patients aged ≥ 70 undergoing decompressive surgery for degenerative cervical myelopathy (DCM) differ from those of younger patients (50–70 years) at 1 year.<p> <p>Methods - Data were obtained from the Norwegian Registry for Spine Surgery (NORspine). Among 651 patients included, 177 (27.2%) were ≥ 70 years old. The ... -
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropathique 4
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-10)Pain is a common symptom in patients referred to polyneuropathy assessment. Diagnostic evaluation and choice of treatment may depend on whether the pain is likely to be neuropathic or not. This study aimed to investigate the diagnostic accuracy of 3 tools commonly used to differentiate between neuropathic and nonneuropathic pain. To accomplish this, we included patients with bilateral distal lower ... -
Both brain size and biological sex contribute to variation in white matter microstructure in middle-aged healthy adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-03)Whether head size and/or biological sex influence proxies of white matter (WM) microstructure such as fractional anisotropy (FA) and mean diffusivity (MD) remains controversial. Diffusion tensor imaging (DTI) indices are also associated with age, but there are large discrepancies in the spatial distribution and timeline of age-related differences reported. The aim of this study was to evaluate the ... -
Diverting stomas reduce reoperation rates for anastomotic leak but not overall reoperation rates within 30 days after anterior rectal resection: a national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)Purpose A diverting stoma is commonly formed to reduce the rate of anastomotic leak following anterior resection with anastomosis, although some studies question this strategy. The aim of this study was to assess the leak rates and overall complication burden after anterior resection with and without a diverting stoma.<p> <p>Methods A 5-year national cohort with prospectively registered data of ... -
Normal and unusual days for dietary intake during the 12 months after a breast cancer diagnosis in women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-24)Purpose There are several reasons to report days as being unusual with regard to dietary intake, including special occasions and celebrations. For breast cancer patients during the 12 month post-surgery period, unusual days may also include days that are afected by being a cancer patient. The aim of this study was to study dietary intake on “normal” and “unusual” days, and to study what is reported ...