Institutt for klinisk medisin: Nye registreringer
Viser treff 481-500 av 1804
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Drawing on the doctor-patient relationship in e-health services
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)The doctor-patient relationship has been the cornerstone of medical practice. As e-health is coming to play an increasingly important role, it is necessary to consider how e-health can draw on, integrate and safeguard aspects of this relationship and thereby improve services and engage patients. -
Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The Norwegian Coronary Stent Trial study is the first to randomize lesions to percutaneous coronary ... -
Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)<p><i>Objective:</i> This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. <p><i>Methods:</i> The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and ... -
Assessment of extracranial metastatic disease in patients with brain metastases: How much effort is needed in the context of evolving survival prediction models?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)Survival prediction models may serve as decision-support tools for clinicians who have to assign the right treatment to each patient, in a manner whereby harmful over- or undertreatment is avoided as much as possible. Current models differ regarding their components, the overall number of components and the weighting of individual components. Some of the components are easy to assess, such as age ... -
Recursive partitioning analysis of systemic therapy after radiotherapy in patients with brain metastases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03)Purpose: The purpose of this study was to identify factors associated with the initiation or continuation of systemic treatment after brain irradiation. The outcome of interest was a utilization rate of at least 75%, given that active extracranial disease is common in patients with brain metastases. If left untreated, extracranial disease limits survival, regardless of successful local treatment of ... -
Prothrombotic genotypes and risk of venous thromboembolism in occult cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)Background - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult ... -
Peripheral chemoreflex activation and cardiac function during hypoxemia in near-term fetal sheep without placental compromise
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)A drop in arterial oxygen content activates fetal chemoreflex including an increase in sympathetic activity leading to peripheral vasoconstriction and redistribution of blood flow to protect the brain, myocardium, and adrenal glands. By using a chronically instrumented fetal sheep model with intact placental circulation at near-term gestation, we investigated the relationship between peripheral ... -
Inntak av meieriprodukter og insidens av diabetes type 2 – en oversiktsartikkel
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06)<p><i>Bakgrunn:</i> Det ses en økende forekomst av diabetes type 2 (T2D) i verden, og kostholdet er en av de viktigste modifiserbare risikofaktorene. Meieriprodukter er en stor kilde til mettede fettsyrer, som er en mulig risikofaktor for T2D. På den andre siden er det sett at flere enkeltnæringsstoffer i meieriprodukter kan virke forebyggende mot T2D. Denne oversiktsartikkelen oppsummerer litteratur ... -
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-15)Polyphosphate is a procoagulant inorganic polymer of linear-linked orthophosphate residues. Multiple investigations have established the importance of platelet polyphosphate in blood coagulation; however, the mechanistic details of polyphosphate homeostasis in mammalian species remain largely undefined. In this study, xenotropic and polytropic retrovirus receptor 1 (XPR1) regulated polyphosphate in ... -
Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)<p><i>Aim:</i> The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. <p><i>Methods:</i> In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), ... -
Intraoperative swept-source OCT–based corneal topography for measurement and analysis of stromal surface after epithelial removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)<p>PURPOSE: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)–based topography/tomography after epithelial removal and to analyze the epithelial contribution to the corneal topography and optics. <p>METHODS: This was a prospective series of 22 eyes of 19 patients referred to receive phototherapeutic keratotomy (PTK) for treatment of ... -
Predicting self-injurious thoughts in daily life using ambulatory assessment of state cognition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)Self-injurious thoughts (SITs) fluctuate considerably from moment to moment. As such, “static” and temporally stable predictors (e.g., demographic variables, prior history) are suboptimal in predicting imminent SITs. This concern is particularly true for “online” cognitive abilities, which are important for understanding SITs, but are typically measured using tests selected for temporal stability. ... -
The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)Background - Systematic training in colonoscopy is highly recommended; however, we have limited knowledge of the effects of “training-the-colonoscopy-trainer” (TCT) courses. Using a national quality register on colonoscopy performance, we aimed to evaluate the effects of TCT participation on defined quality indicators.<p> <p>Methods - This observational study compared quality indicators (pain, ... -
Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-18)Background: Tranexamic acid (TXA) reduce mortality in bleeding trauma patients, with greater efect if administered early. Serum concentrations above 10 µg/mL are considered sufcient to inhibit fbrinolysis. Normally administered intravenously (i.v.), TXA can also be administered intramuscularly (i.m.). This could be advantageous in low resource and military settings, if sufcient serum concentrations ... -
Validation of a graded prognostic model in patients with brain metastases treated with whole-brain radiotherapy instead of radiosurgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan.<p><p> Patients and Methods: This was a retrospective single-institution analysis of 249 patients, managed with whole-brain radiotherapy for brain metastases. The sum of scores was calculated as in the Japanese study. The following parameters ... -
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)<p><b>Background</b> The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. <p><b>Objective</b> To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case–cohort. <p><b>Methods</b> Cases ... -
Palliative radiotherapy during the last month of life: Have COVID-19 recommendations led to reduced utilization?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)Background/Aim: The study aimed to evaluate practice changes in the time period of the early wave of the COVID-19 pandemic. Patients and Methods: This was a retrospective single institution study. We defined palliative radiotherapy (PRT) initiated before Saturday, March 14th as pre-COVID and PRT initiated later as during-COVID (through June 30th). Results: National COVID-19 recommendations ... -
Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-03)Objective To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies.<p> <p>Design and setting Meta-analysis based on individual participant data (IPD).<p> <p>Population or sample Ten centres provided 17 data sets for 21 661 participants, 18 731 ... -
Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)<p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of ... -
The LabBM score is an excellent survival prediction tool in patients undergoing palliative radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)Background and aim: The prognostic assessment of patients referred for palliative radiotherapy can be conducted by sitespecific scores. A quick assessment that would cover the whole spectrum could simplify the working day of clinicians who are not specialists for a particular disease site. This study evaluated a promising score, the LabBM (validated for brain metastases), in patients treated for ...