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dc.contributor.authorStaubo, Sara C.
dc.contributor.authorFuskevåg, Ole Martin
dc.contributor.authorToft, Mathias
dc.contributor.authorLie, Ingeborg H.
dc.contributor.authorAlvik, Kirsti Margrete Johansen
dc.contributor.authorJostad, Pål
dc.contributor.authorTingvoll, Stein H.
dc.contributor.authorLilleng, Hallvard
dc.contributor.authorRosqvist, Kristina
dc.contributor.authorStørset, Elisabet
dc.contributor.authorOdin, Per
dc.contributor.authorDietrichs, Espen
dc.contributor.authorDietrichs, Erik Sveberg
dc.date.accessioned2023-12-12T08:38:11Z
dc.date.available2023-12-12T08:38:11Z
dc.date.issued2023-11-13
dc.description.abstractBackground and purpose: Impulse control disorders (ICDs) are common among Parkinson's disease patients using dopamine agonists. We wanted to determine whether ICD patients have higher dopamine agonist serum concentrations than those without any sign of ICD.<p> <p>Methods: Patients who used either pramipexole or ropinirole depot once daily were screened for ICDs using the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease–Rating Scale. Those who scored above the cut-off for one or more of the four defined ICDs (gambling, compulsive sexual behavior, compulsive shopping, and binge-eating) were compared in a case–control study to patients who scored zero points (no evidence of ICD) on the same items. They were examined clinically and evaluated using relevant scales. Three blood samples were taken on the same day: before daily dose, and then 6 and 12 h later. <p>Results: Forty-six patients were included: 19 ICD-positive and 27 controls. Ropinirole serum concentrations 6 h after daily intake (C<sub>max</sub>) were higher in the case group compared to the control group, as was the daily ropinirole dosage. No differences were observed in serum concentrations, dosage or total drug exposure for pramipexole. Disease duration and length of dopamine agonist treatment was significantly longer among ICD patients for ropinirole, but not for pramipexole. <p>Conclusions: The use of pramipexole may in itself confer high ICD risk, whereas ICDs among ropinirole users depend more on serum concentration and drug exposure. The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD.en_US
dc.identifier.citationStaubo, Fuskevåg, Toft, Lie, Alvik, Jostad, Tingvoll, Lilleng, Rosqvist, Størset, Odin, Dietrichs, Dietrichs. Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease. European Journal of Neurology. 2023en_US
dc.identifier.cristinIDFRIDAID 2196132
dc.identifier.doi10.1111/ene.16144
dc.identifier.issn1351-5101
dc.identifier.issn1468-1331
dc.identifier.urihttps://hdl.handle.net/10037/32019
dc.language.isoengen_US
dc.relation.journalEuropean Journal of Neurology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDopamine agonist serum concentrations and impulse control disorders in Parkinson's diseaseen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)