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dc.contributor.authorTanturri De Horatio, Laura
dc.contributor.authorZadig, Pia Karin Karlsen
dc.contributor.authorvon Brandis, Elisabeth
dc.contributor.authorMüller, Lil-Sofie Ording
dc.contributor.authorRosendahl, Karen
dc.contributor.authorAvenarius, Derk Frederik Matthaus
dc.date.accessioned2023-12-21T12:51:02Z
dc.date.available2023-12-21T12:51:02Z
dc.date.issued2023-07-08
dc.description.abstractObjective: When performing whole-body MRI for bone marrow assessment in children, optimizing scan time is crucial. The aim was to compare T2 Dixon fat-only and TSE T1-weighted sequences in the assessment of bone marrow high signal areas seen on T2 Dixon water-only in healthy children and adolescents. <p><p>Materials and methods: Whole-body MRIs from 196 healthy children and adolescents aged 6 to 19 years (mean 12.0) were obtained including T2 TSE Dixon and T1 TSE-weighted images. Areas with increased signal on T2 Dixon water-only images were scored using a novel, validated scoring system and classified into “minor” or “major” findings according to size and intensity, where “major” referred to changes easily being misdiagnosed as pathology in a clinical setting. Areas were assessed for low signal on T2 Dixon fat-only images and, after at least three weeks to avoid recall bias, on the T1-weighted sequence by two experienced pediatric radiologists. <p>Results: 1250 high signal areas were evaluated on T2 Dixon water-only images. In 1159/1250 (92.7%) low signal was seen on both T2 Dixon fat-only and T1-weighted sequences while in 24 (1.9%) it was not present on either sequence, with an absolute agreement of 94.6%. Discordant findings were found in 67 areas, of which in 18 (1.5%) low signal was visible on T1-weighted images alone and in 49 (3.9%) on T2 Dixon fat-only alone. The overall kappa value between the two sequences was 0.39. The agreement was higher for major as compared to minor findings (kappa values of 0.69 and 0.29, respectively) and higher for the older age groups. <p>Conclusion: T2 Dixon fat-only can replace T1-weighted sequence on whole-body MRI for bone marrow assessment in children over the age of nine, thus reducing scan time.en_US
dc.identifier.citationTanturri De Horatio, Zadig, von Brandis, Müller, Rosendahl, Avenarius. Whole-body MRI in children and adolescents: Can T2-weighted Dixon fat-only images replace standard T1-weighted images in the assessment of bone marrow?. European Journal of Radiology. 2023;166en_US
dc.identifier.cristinIDFRIDAID 2176986
dc.identifier.doi10.1016/j.ejrad.2023.110968
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.urihttps://hdl.handle.net/10037/32198
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEuropean Journal of Radiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleWhole-body MRI in children and adolescents: Can T2-weighted Dixon fat-only images replace standard T1-weighted images in the assessment of bone marrow?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)