Vis enkel innførsel

dc.contributor.authorDyrhovden, Ruben
dc.contributor.authorEagan, Tomas Mikal Lind
dc.contributor.authorFløtten, Øystein
dc.contributor.authorSiljan, William Ward
dc.contributor.authorLeegaard, Truls Michael
dc.contributor.authorBø, Bjørnar
dc.contributor.authorFardal, Hilde
dc.contributor.authorGrøvan, Fredrik
dc.contributor.authorKildahl-Andersen, Arne
dc.contributor.authorLarssen, Kjersti Wik
dc.contributor.authorTilseth, Rune
dc.contributor.authorHjetland, Reidar
dc.contributor.authorLøes, Sigbjørn Suk
dc.contributor.authorLindemark, Frode
dc.contributor.authorTellevik, Marit Gjerde
dc.contributor.authorBreistein, Rebecca Irene
dc.contributor.authorKommedal, Øyvind
dc.date.accessioned2024-01-05T12:05:52Z
dc.date.available2024-01-05T12:05:52Z
dc.date.issued2023-06-22
dc.description.abstractBackground - Many community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such infections are little studied. The aim of the present prospective multicenter cohort study was to provide a thorough microbiological and clinical characterization of such oral-type pleural infections and to improve our understanding of the underlying etiology and associated risk factors.<p> <p>Methods - Over a 2-year period, we included 77 patients with community-acquired pleural infection, whereof 63 (82%) represented oral-type pleural infections. Clinical and anamnestic data were systematically collected, and patients were offered a dental assessment by an oral surgeon. Microbial characterizations were done using next-generation sequencing. Obtained bacterial profiles were compared with microbiology data from previous investigations on odontogenic infections, bacteremia after extraction of infected teeth, and community-acquired brain abscesses.<p> <p>Results - From the oral-type pleural infections, we made 267 bacterial identifications representing 89 different species. Streptococcus intermedius and/or Fusobacterium nucleatum were identified as a dominant component in all infections. We found a high prevalence of dental infections among patients with oral-type pleural infection and demonstrate substantial similarities between the microbiology of such pleural infections and that of odontogenic infections, odontogenic bacteremia, and community-acquired brain abscesses.<p> <p>Conclusions - Oral-type pleural infection is the most common type of community-acquired pleural infection. Current evidence supports hematogenous seeding of bacteria from a dental focus as the most important underlying etiology. Streptococcus intermedius and Fusobacterium nucleatum most likely represent key pathogens necessary for establishing the infection.en_US
dc.identifier.citationDyrhovden, Eagan, Fløtten, Siljan, Leegaard, Bø, Fardal, Grøvan, Kildahl-Andersen, Larssen, Tilseth, Hjetland, Løes, Lindemark, Tellevik, Breistein, Kommedal. Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections. Clinical Infectious Diseases. 2023;77(10):1361-1371
dc.identifier.cristinIDFRIDAID 2208902
dc.identifier.doi10.1093/cid/ciad378
dc.identifier.issn1058-4838
dc.identifier.issn1537-6591
dc.identifier.urihttps://hdl.handle.net/10037/32348
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalClinical Infectious Diseases
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titlePleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infectionsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)