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dc.contributor.authorKnutsen, Erik
dc.contributor.authorSajib, Saikat Das
dc.contributor.authorFiskaa, Tonje
dc.contributor.authorLorens, James Bradley
dc.contributor.authorGudjonsson, Thorarinn
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorJohansen, Steinar Daae
dc.contributor.authorSeternes, Ole Morten
dc.contributor.authorPerander, Maria
dc.date.accessioned2024-01-10T09:55:36Z
dc.date.available2024-01-10T09:55:36Z
dc.date.issued2023-12-04
dc.description.abstractEpithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium is reflected in extensive heterogeneity among breast cancers. Here, we have analyzed RNA-sequencing data from three different mammary epithelial cell line-derived EMT models and identified a robust mammary EMT gene expression signature that separates breast cancers into distinct subgroups. Most strikingly, the basal-like breast cancers form two subgroups displaying partial-EMT and post-EMT gene expression patterns. We present evidence that key EMT-associated transcription factors play distinct roles at different stages of EMT in mammary epithelial cells.en_US
dc.identifier.citationKnutsen, Sajib, Fiskaa, Lorens, Gudjonsson, Mælandsmo, Johansen, Seternes, Perander. Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes. Frontiers in Oncology. 2023;13en_US
dc.identifier.cristinIDFRIDAID 2222431
dc.identifier.doi10.3389/fonc.2023.1249895
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/10037/32398
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleIdentification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)