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dc.contributor.authorBlix, Ellen
dc.contributor.authorBrurberg, Kjetil Gundro
dc.contributor.authorReierth, Eirik
dc.contributor.authorReinar, Liv Merete Brynildsen
dc.contributor.authorØian, Pål
dc.date.accessioned2024-01-15T11:34:02Z
dc.date.available2024-01-15T11:34:02Z
dc.date.issued2023-12-13
dc.description.abstractIntroduction - ST waveform analysis (STAN) was introduced as an adjunct to cardiotocography (CTG) to improve neonatal and maternal outcomes. The aim of the present study was to quantify the efficacy of STAN vs CTG and assess the quality of the evidence using GRADE.<p> <p>Material and methods - We performed systematic literature searches to identify randomized controlled trials and assessed included studies for risk of bias. We performed meta-analyses, calculating pooled risk ratio (RR) or Peto odds ratio (OR). We also performed post hoc trial sequential analyses for selected outcomes to assess the risk of false-positive results and the need for additional studies.<p> <p>Results - Nine randomized controlled trials including 28 729 women were included in the meta-analysis. There were no differences between the groups in operative deliveries for fetal distress (10.9 vs 11.1%; RR 0.96; 95% confidence interval [CI] 0.82–1.11). STAN was associated with a significantly lower rate of metabolic acidosis (0.45% vs 0.68%; Peto OR 0.66; 95% CI 0.48–0.90). Accordingly, 441 women need to be monitored with STAN instead of CTG alone to prevent one case of metabolic acidosis. Women allocated to STAN had a reduced risk of fetal blood sampling compared with women allocated to conventional CTG monitoring (12.5% vs 19.6%; RR 0.62; 95% CI 0.49–0.80). The quality of the evidence was high to moderate.<p< <p>Conclusions - Absolute effects of STAN were minor and the clinical significance of the observed reduction in metabolic acidosis is questioned. There is insufficient evidence to state that STAN as an adjunct to CTG leads to important clinical benefits compared with CTG alone.en_US
dc.identifier.citationBlix, Brurberg, Reierth, Reinar, Øian. ST waveform analysis versus cardiotocography alone for intrapartum fetal monitoring: An updated systematic review and meta-analysis of randomized trials. Acta Obstetricia et Gynecologica Scandinavica. 2023
dc.identifier.cristinIDFRIDAID 2218783
dc.identifier.doi10.1111/aogs.14752
dc.identifier.issn0001-6349
dc.identifier.issn1600-0412
dc.identifier.urihttps://hdl.handle.net/10037/32489
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Obstetricia et Gynecologica Scandinavica
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleST waveform analysis versus cardiotocography alone for intrapartum fetal monitoring: An updated systematic review and meta-analysis of randomized trialsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)