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dc.contributor.authorWang, Mengyun
dc.contributor.authorKorbmacher, Max
dc.contributor.authorEikeland, Rune
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorSpecht, Karsten
dc.date.accessioned2024-01-18T12:37:32Z
dc.date.available2024-01-18T12:37:32Z
dc.date.issued2023-11-20
dc.description.abstractMagnetic resonance spectroscopy (MRS) is the primary method that can measure the levels of metabolites in the brain in vivo. To achieve its potential in clinical usage, the reliability of the measurement requires further articulation. Although there are many studies that investigate the reliability of gamma-aminobutyric acid (GABA), comparatively few studies have investigated the reliability of other brain metabolites, such as glutamate (Glu), N-acetyl-aspartate (NAA), creatine (Cr), phosphocreatine (PCr), or myo-inositol (mI), which all play a significant role in brain development and functions. In addition, previous studies which predominately used only two measurements (two data points) failed to provide the details of the time effect (e.g., time-of-day) on MRS measurement within subjects. Therefore, in this study, MRS data located in the anterior cingulate cortex (ACC) were repeatedly recorded across 1 year leading to at least 25 sessions for each subject with the aim of exploring the variability of other metabolites by using the index coefficient of variability (CV); the smaller the CV, the more reliable the measurements. We found that the metabolites of NAA, tNAA, and tCr showed the smallest CVs (between 1.43% and 4.90%), and the metabolites of Glu, Glx, mI, and tCho showed modest CVs (between 4.26% and 7.89%). Furthermore, we found that the concentration reference of the ratio to water results in smaller CVs compared to the ratio to tCr. In addition, we did not find any time-of-day effect on the MRS measurements. Collectively, the results of this study indicate that the MRS measurement is reasonably reliable in quantifying the levels of metabolites.en_US
dc.identifier.citationWang, Korbmacher, Eikeland, Craven, Specht. The intra-individual reliability of <sup>1</sup>H-MRS measurement in the anterior cingulate cortex across 1 year. Human Brain Mapping. 2023en_US
dc.identifier.cristinIDFRIDAID 2208739
dc.identifier.doi10.1002/hbm.26531
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193
dc.identifier.urihttps://hdl.handle.net/10037/32619
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalHuman Brain Mapping
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleThe intra-individual reliability of 1H-MRS measurement in the anterior cingulate cortex across 1 yearen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)