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dc.contributor.authorSkjeflo, Espen Waage
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorJensen, Søren Beck
dc.contributor.authorLatysheva, Nadezhda
dc.contributor.authorMichelsen, Annika Elisabet
dc.contributor.authorUeland, Thor
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHindberg, Kristian Dalsbø
dc.contributor.authorSnir, Omri
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHansen, John Bjarne
dc.date.accessioned2024-01-19T10:15:12Z
dc.date.available2024-01-19T10:15:12Z
dc.date.issued2023-03-07
dc.description.abstractThe complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE).<p> <p>We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios (ORs) with 95% confidence intervals (95% CI) for VTE across tertiles of CF concentrations were estimated using logistic regression.<p> <p>There was no association between CFB or CFD and risk of future VTE. Higher levels of C3bBbP gave an increased risk of provoked VTE; subjects in Q4 had a 1.68-fold higher OR compared with Q1 in the age-, sex- and BMI-adjusted model (OR 1.68; 95% CI 1.08–2.64).<p> <p>There was no increased risk of future VTE in individuals with higher levels of complement factors B or D of the alternative pathway. Increased levels of the alternative pathway activation product, C3bBbP, showed an association with future risk of provoked VTE.en_US
dc.identifier.citationSkjeflo, Evensen, Jensen, Latysheva, Michelsen, Ueland, Brækkan, Hindberg, Snir, Mollnes, Hansen. Complement factors B, D, C3bBbP and risk of future venous thromboembolism. Clinical Immunology. 2023;249en_US
dc.identifier.cristinIDFRIDAID 2141267
dc.identifier.doi10.1016/j.clim.2023.109278
dc.identifier.issn1521-6616
dc.identifier.issn1521-7035
dc.identifier.urihttps://hdl.handle.net/10037/32626
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Immunology
dc.relation.projectIDNorges forskningsråd: 223255en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleComplement factors B, D, C3bBbP and risk of future venous thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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