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dc.contributor.authorDelanaye, Pierre
dc.contributor.authorVidal-Petiot, Emmanuelle
dc.contributor.authorBjörk, Jonas
dc.contributor.authorEbert, Natalie
dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorDubourg, Laurence
dc.contributor.authorGrubb, Anders
dc.contributor.authorHansson, Magnus
dc.contributor.authorLittmann, Karin
dc.contributor.authorMariat, Christophe
dc.contributor.authorMelsom, Toralf
dc.contributor.authorSchaeffner, Elke
dc.contributor.authorSundin, Per-Ola
dc.contributor.authorBökenkamp, Arend
dc.contributor.authorBerg, Ulla B.
dc.contributor.authorÅsling-Monemi, Kajsa
dc.contributor.authorÅkesson, Anna
dc.contributor.authorLarsson, Anders
dc.contributor.authorCavalier, Etienne
dc.contributor.authorDalton, R Neil
dc.contributor.authorCourbebaisse, Marie
dc.contributor.authorCouzi, Lionel
dc.contributor.authorGaillard, Francois
dc.contributor.authorGarrouste, Cyril
dc.contributor.authorJacquemont, Lola
dc.contributor.authorKamar, Nassim
dc.contributor.authorLegendre, Christophe
dc.contributor.authorRostaing, Lionel
dc.contributor.authorStehlé, Thomas
dc.contributor.authorHaymann, Jean-Philippe
dc.contributor.authorSelistre, Luciano da Silva
dc.contributor.authorStrogoff-de-Matos, Jorge P.
dc.contributor.authorBukabau, Justine B.
dc.contributor.authorSumaili, Ernest K.
dc.contributor.authorYayo, Eric
dc.contributor.authorMonnet, Dagui
dc.contributor.authorNyman, Ulf
dc.contributor.authorPottel, Hans
dc.contributor.authorFlamant, Martin
dc.date.accessioned2024-01-19T10:29:24Z
dc.date.available2024-01-19T10:29:24Z
dc.date.issued2023-08-24
dc.description.abstractBackground - A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts.<p> <p>Methods - Standardized creatinine and measured glomerular filtration rate (GFR) from the European EKFC cohorts (n = 13 856 including 6031 individuals in the external validation cohort), from France (n = 4429, including 964 Black Europeans), from Brazil (n = 100) and from Africa (n = 508) were used to test the performances of the equations. A matched analysis between White Europeans and Black Africans or Black Europeans was performed.<p> <p>Results - In White Europeans (n = 9496), both the EKFC and LMREV equations outperformed CKD-EPIAS (bias of –0.6 and –3.2, respectively versus 5.0 mL/min/1.73 m², and accuracy within 30% of 86.9 and 87.4, respectively, versus 80.9%). In Black Europeans and Black Africans, the best performance was observed with the EKFC equation using a specific Q-value (= concentration of serum creatinine in healthy males and females). These results were confirmed in matched analyses, which showed that serum creatinine concentrations were different in White Europeans, Black Europeans and Black Africans for the same measured GFR, age, sex and body mass index. Creatinine differences were more relevant in males.<p> <p>Conclusion - In a European and African cohort, the performances of CKD-EPIAS remain suboptimal. The EKFC equation, using usual or dedicated population-specific Q-values, presents the best performance in the whole age range in the European and African populations included in this study.en_US
dc.identifier.citationDelanaye, Vidal-Petiot, Björk, Ebert, Eriksen, Dubourg, Grubb, Hansson, Littmann, Mariat, Melsom, Schaeffner, Sundin, Bökenkamp, Berg, Åsling-Monemi, Åkesson, Larsson, Cavalier, Dalton, Courbebaisse, Couzi, Gaillard, Garrouste, Jacquemont, Kamar, Legendre, Rostaing, Stehlé, Haymann, Selistre, Strogoff-de-Matos, Bukabau, Sumaili, Yayo, Monnet, Nyman, Pottel, Flamant. Performance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africa. Nephrology, Dialysis and Transplantation. 2023;38(1):106-118
dc.identifier.cristinIDFRIDAID 2141569
dc.identifier.doi10.1093/ndt/gfac241
dc.identifier.issn0931-0509
dc.identifier.issn1460-2385
dc.identifier.urihttps://hdl.handle.net/10037/32634
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalNephrology, Dialysis and Transplantation
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titlePerformance of creatinine-based equations to estimate glomerular filtration rate in White and Black populations in Europe, Brazil and Africaen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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