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dc.contributor.authorMorra, Anna
dc.contributor.authorSchreurs, Maartje A. C.
dc.contributor.authorAndrulis, Irene L.
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorAugustinsson, Annelie
dc.contributor.authorBeckmann, Matthias W.
dc.contributor.authorBehrens, Sabine
dc.contributor.authorBojesen, Stig E.
dc.contributor.authorBolla, Manjeet K.
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBroeks, Annegien
dc.contributor.authorBuys, Saundra S.
dc.contributor.authorCamp, Nicola J.
dc.contributor.authorCastelao, Jose E.
dc.contributor.authorCessna, Melissa H.
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorChung, Wendy K.
dc.contributor.authorSahlberg, Guro Kristine Kleivi
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorOlsen, Karina Standahl
dc.contributor.authorEngebråten, Olav
dc.contributor.authorNaume, Bjørn
dc.contributor.authorGeisler, Jürgen
dc.contributor.authorGrenaker, Grethe Irene
dc.contributor.authorColonna, Sarah V.
dc.contributor.authorCouch, Fergus J.
dc.contributor.authorCox, Angela
dc.contributor.authorCross, Simon S.
dc.contributor.authorCzene, Kamila
dc.contributor.authorDaly, Mary B.
dc.contributor.authorDennis, Joe
dc.contributor.authorDevilee, Peter
dc.contributor.authorDörk, Thilo
dc.contributor.authorDunning, Alison M.
dc.contributor.authorDwek, Miriam
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorEccles, Diana M.
dc.contributor.authorEriksson, Mikael
dc.contributor.authorEvans, D. Gareth
dc.contributor.authorFasching, Peter A.
dc.contributor.authorFehm, Tanja N.
dc.contributor.authorFigueroa, Jonine D.
dc.contributor.authorFlyger, Henrik
dc.contributor.authorGabrielson, Marike
dc.contributor.authorGago-Dominguez, Manuela
dc.contributor.authorGarcía-Closas, Montserrat
dc.contributor.authorGarcía-Sáenz, José A.
dc.contributor.authorGenkinger, Jeanine
dc.contributor.authorGrassmann, Felix
dc.contributor.authorGündert, Melanie
dc.contributor.authorHahnen, Eric
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHamann, Ute
dc.contributor.authorHarrington, Patricia A.
dc.contributor.authorHartikainen, Jaana M.
dc.contributor.authorHoppe, Reiner
dc.contributor.authorHopper, John L.
dc.contributor.authorHoulston, Richard S.
dc.contributor.authorHowell, Anthony
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJanni, Wolfgang
dc.contributor.authorJernström, Helena
dc.contributor.authorJohn, Esther M.
dc.contributor.authorJohnson, Nichola
dc.contributor.authorJones, Michael E.
dc.contributor.authorKristensen, Vessela N.
dc.contributor.authorKurian, Allison W.
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLindblom, Annika
dc.contributor.authorLubiński, Jan
dc.contributor.authorLux, Michael P.
dc.contributor.authorMannermaa, Arto
dc.contributor.authorMavroudis, Dimitrios
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorMuranen, Taru A.
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNevelsteen, Ines
dc.contributor.authorNeven, Patrick
dc.contributor.authorNewman, William G.
dc.contributor.authorObi, Nadia
dc.contributor.authorOffit, Kenneth
dc.contributor.authorOlshan, Andrew F.
dc.contributor.authorPark-Simon, Tjoung-Won
dc.contributor.authorPatel, Alpa V.
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPhillips, Kelly-Anne
dc.contributor.authorPlaseska-Karanfilska, Dijana
dc.contributor.authorPolley, Eric C.
dc.contributor.authorPresneau, Nadege
dc.contributor.authorPylkäs, Katri
dc.contributor.authorRack, Brigitte
dc.contributor.authorRadice, Paolo
dc.contributor.authorRashid, Muhammad U.
dc.contributor.authorRhenius, Valerie
dc.contributor.authorRobson, Mark
dc.contributor.authorRomero, Atocha
dc.contributor.authorSaloustros, Emmanouil
dc.contributor.authorSawyer, Elinor J.
dc.contributor.authorSchmutzler, Rita K.
dc.contributor.authorSchuetze, Sabine
dc.contributor.authorScott, Christopher
dc.contributor.authorShah, Mitul
dc.contributor.authorSmichkoska, Snezhana
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorTapper, William J.
dc.contributor.authorTeras, Lauren R.
dc.contributor.authorTollenaar, Rob A. E. M.
dc.contributor.authorTomczyk, Katarzyna
dc.contributor.authorTomlinson, Ian
dc.contributor.authorTroester, Melissa A.
dc.contributor.authorVachon, Celine M.
dc.contributor.authorvan Veen, Elke M.
dc.contributor.authorWang, Qin
dc.contributor.authorWendt, Camilla
dc.contributor.authorWildiers, Hans
dc.contributor.authorWinqvist, Robert
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorHall, Per
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorAdank, Muriel A.
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorSchmidt, Marjanka K.
dc.contributor.authorHooning, Maartje J.
dc.date.accessioned2024-02-06T11:53:59Z
dc.date.available2024-02-06T11:53:59Z
dc.date.issued2023-07-03
dc.description.abstractBackground - Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.<p> <p>Aim - To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.<p> <p>Methods - Analyses were based on 82,701 women diagnosed with a first primary invasive BC including 963 CHEK2 c.1100delC carriers; median follow-up was 9.1 years. Differential associations with treatment by CHEK2 c.1100delC status were tested by including interaction terms in a multivariable Cox regression model. A multi-state model was used for further insight into the relation between CHEK2 c.1100delC status, treatment, CBC risk and death.<p> <p>Results - There was no evidence for differential associations of therapy with CBC risk by CHEK2 c.1100delC status. The strongest association with reduced CBC risk was observed for the combination of chemotherapy and endocrine therapy [HR (95% CI): 0.66 (0.55–0.78)]. No association was observed with radiotherapy. Results from the multi-state model showed shorter BCSS for CHEK2 c.1100delC carriers versus non-carriers also after accounting for CBC occurrence [HR (95% CI): 1.30 (1.09–1.56)].<p> <p>Conclusion - Systemic therapy was associated with reduced CBC risk irrespective of CHEK2 c.1100delC status. Moreover, CHEK2 c.1100delC carriers had shorter BCSS, which appears not to be fully explained by their CBC risk.en_US
dc.identifier.citationMorra, Schreurs, Andrulis, Anton-Culver, Augustinsson, Beckmann, Behrens, Bojesen, Bolla, Brauch, Broeks, Buys, Camp, Castelao, Cessna, Chang-Claude, Chung, Sahlberg, Børresen-Dale, Gram, Olsen, Engebråten, Naume, Geisler, Grenaker, Colonna, Couch, Cox, Cross, Czene, Daly, Dennis, Devilee, Dörk, Dunning, Dwek, Easton, Eccles, Eriksson, Evans, Fasching, Fehm, Figueroa, Flyger, Gabrielson, Gago-Dominguez, García-Closas, García-Sáenz, Genkinger, Grassmann, Gündert, Hahnen, Haiman, Hamann, Harrington, Hartikainen, Hoppe, Hopper, Houlston, Howell, Jakubowska, Janni, Jernström, John, Johnson, Jones, Kristensen, Kurian, Lambrechts, Le Marchand, Lindblom, Lubiński, Lux, Mannermaa, Mavroudis, Mulligan, Muranen, Nevanlinna, Nevelsteen, Neven, Newman, Obi, Offit, Olshan, Park-Simon, Patel, Peterlongo, Phillips, Plaseska-Karanfilska, Polley, Presneau, Pylkäs, Rack, Radice, Rashid, Rhenius, Robson, Romero, Saloustros, Sawyer, Schmutzler, Schuetze, Scott, Shah, Smichkoska, Southey, Tapper, Teras, Tollenaar, Tomczyk, Tomlinson, Troester, Vachon, van Veen, Wang, Wendt, Wildiers, Winqvist, Ziogas, Hall, Pharoah, Adank, Hollestelle, Schmidt, Hooning. Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival. Cancer Medicine. 2023;12(15):16142-16162en_US
dc.identifier.cristinIDFRIDAID 2242553
dc.identifier.doi10.1002/cam4.6272
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/10037/32850
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalCancer Medicine
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/633784/Netherlands/Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes/B-CAST/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/634935/Netherlands/Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES)/BRIDGES/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAssociation of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survivalen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)