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dc.contributor.authorSahakyan, Mushegh
dc.contributor.authorAghayan, Davit
dc.contributor.authorEdwin, Bjørn von Gohren
dc.contributor.authorAlikhanov, Ruslan
dc.contributor.authorBritskaia, Natalia
dc.contributor.authorBrudvik, Kristoffer Watten
dc.contributor.authorD’Hondt, Mathieu
dc.contributor.authorDe Meyere, Celine
dc.contributor.authorEfanov, Mikhail
dc.contributor.authorFretland, Åsmund Avdem
dc.contributor.authorHoff, Rune
dc.contributor.authorIsmail, Warsan
dc.contributor.authorIvanecz, Arpad
dc.contributor.authorKazaryan, Airazat M.
dc.contributor.authorLassen, Kristoffer
dc.contributor.authorMagdalenic, Tomislav
dc.contributor.authorParmentier, Isabelle
dc.contributor.authorRøsok, Bård Ingvald
dc.contributor.authorVillanger, Olaug
dc.contributor.authorYakub, Sheraz
dc.date.accessioned2024-02-22T09:45:31Z
dc.date.available2024-02-22T09:45:31Z
dc.date.issued2022-11-14
dc.description.abstractBackground - The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC.<p> <p>Methods - Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches were compared in terms of surgical and oncological outcomes. Propensity score matching was used for minimizing treatment selection bias and adjusting for confounders (age, ASA grade, tumor size, location, number of tumors and underlying liver disease).<p> <p>Results - Of 136 patients, 50 (36.7%) underwent laparoscopic resection, whereas 86 (63.3%) had open surgery. Median tumor size was larger (73.6 vs 55.1 mm, p = 0.01) and the incidence of bi-lobar tumors was higher (36.6 vs 6%, p < 0.01) in patients undergoing open surgery. After propensity score matching baseline characteristics were comparable although open surgery was associated with a larger fraction of major liver resections (74 vs 38%, p < 0.01), lymphadenectomy (60 vs 20%, p < 0.01) and longer operative time (294 vs 209 min, p < 0.01). Tumor characteristics were similar. Laparoscopic resection resulted in less complications (30 vs 52%, p = 0.025), fewer reoperations (4 vs 16%, p = 0.046) and shorter hospital stay (5 vs 8 days, p < 0.01). No differences were found in terms of recurrence, recurrence-free and overall survival.<p> <p>Conclusion - Laparoscopic resection seems to be associated with improved short-term and with similar long-term outcomes compared with open surgery in patients with ICC. However, possible selection criteria for laparoscopic surgery are yet to be defined.en_US
dc.identifier.citationSahakyan M, Aghayan D, Edwin B, Alikhanov R, Britskaia N, Brudvik KW, D’Hondt M, De Meyere C, Efanov M, Fretland ÅA, Hoff R, Ismail W, Ivanecz A, Kazaryan AM, Lassen K, Magdalenic, Parmentier I, Røsok BI, Villanger O, Yakub S. Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: amulticenter propensity score-matched study. Scandinavian Journal of Gastroenterology. 2023;58(5)en_US
dc.identifier.cristinIDFRIDAID 2248088
dc.identifier.doihttps://doi.org/10.1080/00365521.2022.2143724
dc.identifier.issn0036-5521
dc.identifier.issn1502-7708
dc.identifier.urihttps://hdl.handle.net/10037/33005
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalScandinavian Journal of Gastroenterology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titleLaparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: amulticenter propensity score-matched studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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