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dc.contributor.authorHuijgens, Patty Thalia
dc.contributor.authorHeijkoop, Roy
dc.contributor.authorVanderschuren, Louk
dc.contributor.authorLesscher, Heidi
dc.contributor.authorSnoeren, Eelke Mirthe Simone
dc.date.accessioned2024-02-26T12:36:48Z
dc.date.available2024-02-26T12:36:48Z
dc.date.issued2024-02-24
dc.description.abstractThis study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects interacted with the internal state of the animals. Through detailed behavioral analysis, it was demonstrated that CaMKIIa+neurons in the BNST play a significant role in the regulation of both sexual behavior and sucrose self-administration. Although the behavioral outcome measures differed between the two behaviors, the regula tory role of the CaMKIIa+neurons in the BNST was found to converge on the modulation of the pacing of engagement in these behaviors in male rats. Moreover, our study confirmed that the internal physiological state of the animal affects how the BNST modulates these behaviors. These findings suggest that different types of natural rewards may recruit a similar brain circuitry to regulate the display of motivated behaviors. Overall, this research provides valuable insights into the neural mechanisms underlying natural reward seeking and sheds light on the interconnected nature of reward-related behaviors in male rats.en_US
dc.identifier.citationHuijgens, Heijkoop, Vanderschuren, Lesscher, Snoeren. CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state. Psychopharmacology. 2024en_US
dc.identifier.cristinIDFRIDAID 2249437
dc.identifier.doi10.1007/s00213-024-06561-5
dc.identifier.issn0033-3158
dc.identifier.issn1432-2072
dc.identifier.urihttps://hdl.handle.net/10037/33039
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalPsychopharmacology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleCaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal stateen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)