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dc.contributor.authorNolsøe, Jens Mortansson Jelstrup
dc.contributor.authorUnderhaug, Jarl
dc.contributor.authorSørskår, Åshild Moi
dc.contributor.authorAntonsen, Simen
dc.contributor.authorMalterud, Karl Egil
dc.contributor.authorGani, Osman
dc.contributor.authorFan, Qiong
dc.contributor.authorHjorth, Marit
dc.contributor.authorSæther, Thomas
dc.contributor.authorHansen, Trond Vidar
dc.contributor.authorH. Stenstrøm, Yngve
dc.date.accessioned2024-02-27T14:54:50Z
dc.date.available2024-02-27T14:54:50Z
dc.date.issued2024-02-24
dc.description.abstractNatural products obtained from marine organisms continue to be a rich source of novel structural architecture and of importance in drug discovery, medicine, and health. However, the success of such endeavors depends on the exact structural elucidation and access to sufficient material, often by stereoselective total synthesis, of the isolated natural product of interest. (−)-Mucosin (1), a fatty acid derivative, previously presumed to contain a rare cis-bicyclo[4.3.0]non-3-ene moiety, has since been shown to be the trans-congener. Analytically, the fused bicyclic ring system in (−)-1 constitutes a particular challenge in order to establish its relative and absolute stereochemistry. Herein, data from biological evaluations, NMR and molecular modeling studies of (−)-1 are presented. An overview of the synthetic strategies enabling the exact structural elucidation of (−)-mucosin (1) is also presented.en_US
dc.identifier.citationNolsøe, Underhaug, Sørskår, Antonsen, Malterud, Gani, Fan, Hjorth, Sæther, Hansen, H. Stenstrøm. Biological Evaluations, NMR Analyses, Molecular Modeling Studies, and Overview of the Synthesis of the Marine Natural Product (−)-Mucosin. Molecules. 2024;29(5)en_US
dc.identifier.cristinIDFRIDAID 2249618
dc.identifier.doi10.3390/molecules29050994
dc.identifier.issn1431-5157
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/33058
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMolecules
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleBiological Evaluations, NMR Analyses, Molecular Modeling Studies, and Overview of the Synthesis of the Marine Natural Product (−)-Mucosinen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)