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dc.contributor.authorAverina, Maria
dc.contributor.authorHuber, Sandra
dc.contributor.authorAlmås, Bjørg
dc.contributor.authorBrox, Jan
dc.contributor.authorJacobsen, Bjarne K.
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorGrimnes, Guri
dc.date.accessioned2024-03-25T09:44:17Z
dc.date.available2024-03-25T09:44:17Z
dc.date.issued2023-11-19
dc.description.abstractBackground: Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents. <p> <p>Methods: Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones were measured in 921 adolescents aged 15–19 years in the Fit Futures study, Northern Norway. The questionnaire included data on self-reported age at menarche and puberty development score (PDS). Multiple linear and logistic regression analyses and principle component analyses (PCA) were used to assess associations of PFAS with hormones concentrations and puberty indices. <p> <p>Results: In girls, total PFAS (∑PFAS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorodecanoate (PFDA) were positively associated with dehydroepiandrosterone sulfate (DHEAS) and negatively associated with 11-deoxycorticosterone (11-DOC)/DHEAS ratio. In boys, the associations with 11-DOC/DHEAS ratio were positive for ∑PFAS, perfluoroheptanoate (PFHpA), perfluoroheptane sulfonate (PFHpS), PFOA, and PFOS. Perfluoroundecanoate (PFUnDA) was negatively associated with free thyroxine (fT4) and free triiodothyronine (fT3) in boys. PFNA and PFDA were also negatively associated with fT3 in boys. Serum parathyroid hormone concentration (PTH) was negatively associated with ∑PFAS and perfluorohexane sulfonate (PFHxS) in girls, and with PFOS in boys. PFDA and PFUnDA were positively associated with early menarche, while ∑PFAS and PFOA were positively associated with PDS in boys. <p> <p>No associations of PFAS with serum testosterone, follicle-stimulating hormone, or luteinizing hormone were found in either sex. In girls, PFOA was positively associated with free testosterone index (FTI). In boys, PFOA was positively associated with androstendione and 17-OH-progesterone, while PFHpA was positively associated with estradiol. <p> <p>Conclusions: Serum concentrations of several PFAS were associated with parathyroid and steroid hormones in both sexes, and with thyroid hormones in boys, as well as with early menarche in girls and higher PDS in boys.en_US
dc.identifier.citationAverina M, Huber SH, Almås B, Brox J, Jacobsen bk, Furberg A-S, Grimnes G. Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study. Environmental Research. 2023;242
dc.identifier.cristinIDFRIDAID 2201549
dc.identifier.doi10.1016/j.envres.2023.117703
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/33256
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.titleEarly menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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