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dc.contributor.authorMoksnes, Marta Riise
dc.contributor.authorHansen, Ailin Falkmo
dc.contributor.authorWolford, Brooke
dc.contributor.authorThomas, Laurent Francois
dc.contributor.authorRasheed, Humaira
dc.contributor.authorSimic, Anica
dc.contributor.authorBhatta, Laxmi
dc.contributor.authorBrantsæter, Anne Lise
dc.contributor.authorSurakka, Ida
dc.contributor.authorZhou, Wei
dc.contributor.authorMagnus, Per Minor
dc.contributor.authorNjølstad, Pål Rasmus
dc.contributor.authorAndreassen, Ole
dc.contributor.authorSyversen, Tore
dc.contributor.authorZheng, Jie
dc.contributor.authorFritsche, Lars
dc.contributor.authorEvans, David M.
dc.contributor.authorWarrington, Nicole Maree
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorFlaten, Trond Peder
dc.contributor.authorWiller, Cristen J.
dc.contributor.authorHveem, Kristian
dc.contributor.authorBrumpton, Ben Michael
dc.date.accessioned2024-06-04T11:21:10Z
dc.date.available2024-06-04T11:21:10Z
dc.date.issued2024-04-09
dc.description.abstractTrace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements. We perform genome-wide association meta-analyses of 14 trace elements in up to 6564 Scandinavian whole blood samples, and genome-wide association studies of 43 trace elements in up to 2819 samples measured only in the Trøndelag Health Study (HUNT). We identify 11 novel genetic loci associated with blood concentrations of arsenic, cadmium, manganese, selenium, and zinc in genome-wide association meta-analyses. In HUNT, several genome-wide significant loci are also indicated for other trace elements. Using two-sample Mendelian randomization, we find several indications of weak to moderate effects on health outcomes, the most precise being a weak harmful effect of increased zinc on prostate cancer. However, independent validation is needed. Our current understanding of trace element-associated genetic variants may help establish consequences of trace elements on human health.en_US
dc.identifier.citationMoksnes, Hansen, Wolford, Thomas, Rasheed, Simic, Bhatta, Brantsæter, Surakka, Zhou, Magnus, Njølstad, Andreassen, Syversen, Zheng, Fritsche, Evans, Warrington, Nøst, Åsvold, Flaten, Willer, Hveem, Brumpton. A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans. Communications Biology. 2024;7(1)en_US
dc.identifier.cristinIDFRIDAID 2264921
dc.identifier.doi10.1038/s42003-024-06101-z
dc.identifier.issn2399-3642
dc.identifier.urihttps://hdl.handle.net/10037/33715
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalCommunications Biology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humansen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)