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norskInstitutt for medisinsk biologi: Recent submissions
Now showing items 1141-1160 of 1205
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The RISAP-study : a complex intervention in risk communication and shared decision-making in general practice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Gene expression, function and ischemia tolerance in male and female rat hearts after sub-toxic levels of Angiotensin II
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Homeopati og bivirkninger
(Chronicle; Kronikk, 2010) -
Dairy consumption and calcium intake and risk of breast cancer in a prospective cohort : The Norwegian Women and Cancer study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Recruitment methods in Alzheimer's disease research : general practice versus population based screening by mail
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Understanding unexpected courses of multiple sclerosis among patients using complementary and alternative medicine : A travel from recipient to explorer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa - a literature review and focus group study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Human articular chondrocytes express Chemerin receptor, ChemR23, which conveys inflammatory signalling
(Master thesis; Mastergradsoppgave, 2008-12-17)Common features of arthritis include destruction of extracellular matrices in cartilage and bone as a result of chronic inflammation. Cartilage deterioration is generally described as a result from the effect of immune cells and their inflammatory mediators. However, recent reports suggest a role of chondrocytes in the initiation of inflammation in joints, and that they play a pivotal role in the ... -
Effect of Unfractionated Heparin on TFPI Elimination
(Journal article; Tidsskriftartikkel, 2010)Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ... -
Asialoglycoprotein Receptor (ASGP-R) is Liver Parenchymal Cells is Involved in Elimination of Recombinant Human TFPI
(Journal article; Tidsskriftartikkel, 2010)We here report on a study carried out to determine the early clearance kinetics, and organ, cell(s) and receptor(s) responsible for the clearance of full length TFPI purified from BHK cells (TFPI<sup>BHK</sup>). Following intravenous administration, <sup>125</sup>I-TFPI<sup>BHK</sup> was cleared with a biphasic elimination curve, and with a significantly slower t<sub>1/2</sub>α compared to recombinant ... -
Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis
(Tidsskriftartikkel; Peer reviewed; Journal article, 2010-08-10)Background: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice. As this may represent a basic mechanism in the progression of lupus nephritis, several aspects of ... -
Downstream gene expression of wild type p53 tumor suppressor gene versus mutated and null p53
(Master thesis; Mastergradsoppgave, 2006-11)P53 is a key tumor suppressor and transcription factor protecting us from cancer. The wild type p53 protein functions as a regulatory protein, triggering a variety of cellular responses to different signals. Activation of p53 can lead to cell division arrest, DNA repair, or apoptosis. More than 60% of all human cancers contain p53 mutations. P53 is also reported in many studies to play a role in the ... -
The antioxidant system of arctic seabirds and the effect of HOCs on antioxidant capacity of kidney tissue
(Master thesis; Mastergradsoppgave, 2010-06-15)The arctic is exposed to a wide range of pollutants which originate from industrialized areas located in temperate regions. Halogenated organic contaminants (HOCs) are of special concern due to their persistency and ability to bioaccumulate. Consequently, animals high in the food chain, such as marine seabirds, are prone to accumulate high levels of these compounds. The HOCs are known to increase ... -
King crab proteases: as stimulators of an inflammatory pathway in human airway epithelial cells
(Master thesis; Mastergradsoppgave, 2010-03-22)In these studies, we focus on moricrase (enzyme mixture from hapatopancreas of king crab) as an activator of inflammatory responses in airway cells. Taking under consideration that serine proteases, such as trypsin, are stimulator of interlukin-8 (IL-8). We investigate the role of protease activated receptor 2 (PAR-2) in the inflammation of human pulmonary epithelial cells (A549). A549 cells were ... -
The biological cost of genetic elements.
(Master thesis; Mastergradsoppgave, 2010-03-15)The emergence and increase of antimicrobial resistance among bacterial populations has raised interest in the factor that contributes to this situation. Mobile genetic elements and in particular integrons have been found to play a role in the spread of resistance genes due to their ability to capture and integrate one or more gene cassettes by site-specific recombination. The genes can be integrated ... -
Prognostic Impact of Fibroblast Growth Factor 2 in NSCLC : Co-Expression with VEGFR-3 and PDGF-B Predicts Poor Survival
(Tidsskriftartikkel; Peer reviewed; Journal article, 2009-05)Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis. Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact ...
