Institutt for medisinsk biologi: Nye registreringer

Viser treff 661-680 av 1202

    • Thermoregulatory responses and work strain of fishermen – a field study on board deep-sea fishing vessels. 

      Høye, Erik Ulvolden; Sandsund, Mariann; Heidelberg, Cecilie Thon; Aasmoe, lisbeth; Reinertsen, Randi Eidsmo (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-28)
      Background: Fishermen working on deep-sea vessels in the Barents and Norwegian Sea are exposed to low air temperatures, strong winds, high humidity, rain, snow and work at different intensities. Few studies have investigated the effect of environmental work factors on the physiology of this occupational group. The aim of the study was to investigate work strain and thermophysiological responses of ...

    • Serine-aspartate-repeat protein D Increases Staphylococcus aureus Virulence and Survival in Blood 

      Askarian, Fatemeh; Uchiyama, Satoshi; Valderrama, J. Andrés; Ajayi, Clement; Sollid, Johanna U. E.; Van Sorge, Nina M.; Nizet, Victor; van strijp, Jos A. G.; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by the serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion of sdrD from S. aureus subsp. aureus strain NCTC8325-4 attenuated bacterial survival ...

    • Heat for wounds - water filtered infrared-A for wound healing- a review. 

      Hoffmann, Gerd; Hartel, M; Mercer, James (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-29)
      Background:<br>Water-filtered infrared-A (wIRA) is a special form of heat radiation with high tissue penetration and a low thermal load to the skin surface. wIRA corresponds to the major part of the sun’s heat radiation, which reaches the surface of the Earth in moderate climatic zones filtered by water and water vapour of the atmosphere. wIRA promotes healing of acute and chronic wounds both by ...

    • Assessing PDL-1 and PD-1 in NoneSmall Cell Lung Cancer: A Novel Immunoscore Approach 

      Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaee, Mehrdad; Al-Saad, Samer; Hald, Sigurd; Andersen, Sigve; Richardsen, Elin; Ness, Nora; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
      Novel immune biomarkers could complement the TNM classification for nonesmall cell cancer (NSCLC), improving the prognostic accuracy. The present study evaluated the prognostic significance of the immune checkpoint molecules programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1) in 536 patients with stage I to IIIA NSCLC using an Immunoscore approach. Independently, and in combination, ...

    • The oncolytic peptide LTX-315 triggers immunogenic cell death 

      Zhou, Heng; Forveille, Sabrina; Sauvat, Allan; Yamazaki, T; Senovilla, L; Ma, Y; Liu, Peng; Yang, H; Bezu, L; Müller, K; Zitvogel, Laurence; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-10)
      LTX-315 is a cationic amphilytic peptide that preferentially permeabilizes mitochondrial membranes, thereby causing partially BAX/ BAK1-regulated, caspase-independent necrosis. Based on the observation that intratumorally injected LTX-315 stimulates a strong T lymphocyte-mediated anticancer immune response, we investigated whether LTX-315 may elicit the hallmarks of immunogenic cell death (ICD), ...

    • Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis 

      Rushfeldt, Christian; Agledahl, Uwe; Sveinbjørnsson, Baldur; Søreide, Kjetil; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)
      Background Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively. Methods This study includes a consecutive series of patients having surgery involving ...

    • Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2a-mediated stress signaling 

      Santos, Celio X.C.; Hafstad, Anne Dragøy; Beretta, Matteo; Zhang, Min; Molenaar, Chris; Kopec, Jola; Fotinou, Dina; Murray, Thomas V.; Cobb, Andrew M.; Martin, Daniel; Zeh Silva, Maira; Anilkumar, Narayana; Schröder, Katrin; Shanahan, Catherine M.; Brewer, Alison C.; Brandes, Ralf P.; Blanc, Eric; Parsons, Maddy; Belousov, Vsevelod; Cammack, Richard; Hider, Robert C.; Steiner, Roberto A.; Shah, Ajay M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-07)
      Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2α phosphorylation enhances cell survival. Here, we show ...

    • Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD 

      Goode, Alice; Butler, Kevin; Long, Jed; Cavey, James; Scott, Daniel; Shaw, Barry; Sollenberger, Jill; Gell, Christopher; Johansen, Terje; Oldham, Neil J.; Searle, Mark S.; Layfield, Robert (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-12)
      Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is genetically associated with ALS-FTLD, although to date autophagy-relevant functional defects in disease-ass ...

    • Silenced vanA gene cluster on a transferable plasmid cause outbreak of vancomycin variable enterococci 

      Sivertsen, Audun; Pedersen, Torunn Annie; Larssen, Kjersti Wik; Bergh, Kåre; Rønning, Torunn Gresdal; Radtke, Andreas; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-02)
      We report an outbreak of vancomycin-variable vanA+ enterococci (VVE) able to escape phenotypic detection by current guide- lines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and horizontal spread of the vanA cluster. Forty-eight vanA+ Enterococcus faecium isolates and one Enterococcus faecalis isolate were analyzed for clonality with pulsed-field ...

    • Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study 

      Norvik, Jon Viljar; Storhaug, Hilde-Merete; Ytrehus, Kirsti; Jenssen, Trond Geir; Zykova, Svetlana; Eriksen, Bjørn Odvar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)
      Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ...

    • The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis 

      Snapkov, Igor; Öqvist, Carl Otto; Figenschau, Yngve Anton; Kogner, Per; Johnsen, John Inge; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-18)
      Background: Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood. Methods: Expression of FPR1 in neuroblastoma cell lines and primary ...

    • FITC conjugation markedly enhances hepatic clearance of N-formyl peptides 

      Øie, Cristina Ionica; Snapkov, Igor; Elvevold, Kjetil; Sveinbjørnsson, Baldur; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)
      In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock. The inflammatory response is brought about by the binding of N-formyl peptide to formyl peptide receptors (FPRs), specific signaling receptors expressed on myeloid as well as non-myeloid cells involved in the ...

    • Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome 

      Grindstad, Thea; Skjefstad, Kaja; Andersen, Sigve; Ness, Nora; Nordby, Yngve; Al-Saad, Samer; Fismen, Silje; Dønnem, Tom; Rakaee, Mehrdad; Busund, Lill-Tove; Bremnes, Roy M.; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)
      Androgens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays ...

    • Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer 

      Puvirajesinghe, Tania M.; Bertucci, François; Jain, Ashish; Scerbo, Pierluigi; Belotti, Edwige; Audebert, Stéphane; Sebbagh, Michael; Lopez, Marc; Brech, Andreas; Finetti, Pascal; Charafe-Jauffret, Emmanuelle; Chaffanet, Max; Restouin, Audrey; Marchetto, Sylvie; Collette, Yves; Gonçalvès, Anthony; Macara, Ian; Birnbaum, Daniel; Kodjabachian, Laurent; Johansen, Terje; Borg, Jean-Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-12)
      The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as a therapeutic target. Here we show that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumour ...

    • Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study 

      Andersen, Sigve; Richardsen, Elin; Moi, Line; Dønnem, Tom; Nordby, Yngve; Ness, Nora; Eilertsen Holman, Marte; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)
      There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy patients ...

    • Altered pharmacological effects of adrenergic agonists during hypothermia 

      Dietrichs, Erik Sveberg; Sager, Georg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
      Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ...

    • Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia 

      Weng, Ying-Jan; Husebekk, Anne; Skogen, Bjørn Ragnar; Killie, Mette Kjær; Lin, Liang-Tzung; Burnouf, Thierry (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe disease that is caused by maternal alloantibodies generated during pregnancy or at delivery as a result of incompatibility between maternal and fetal human platelet antigens (HPAs) inherited from the father. Antibody-mediated immune suppression using anti-HPA-1a immunoglobulins is thought to be able to prevent FNAIT caused by ...

    • Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer 

      Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Tidsskriftartikkel; Peer reviewed; Journal article, 2016-06-03)
      TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated approach, combining metabolomics, transcriptomics, histopathology and clinical data in a cohort of 129 human prostate samples (41 patients). Metabolic analyses revealed lower con ...

    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-24)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A newly discovered NCWP, Wnt5/Fzd2, has been shown to induce epithelial-to-mesenchymal transition (EMT) in cancers, but has not been investigated in prostate cancer. The aim of this ...

    • Direct small RNA signatures in extracellular vesicles from breast cancer cell lines 

      Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, Maria; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)
      Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules ...