<i>Background</i>: The developing fetus is particularly vulnerable to the effects of endocrine disrupting chemicals (EDCs). Molecular fingerprints of EDCs can be identified via microRNA (miRNA) expression profiles and may be etiologically implicated in the developmental origin of disease (DOHaD).<p> <p><i>Methods/design</i>: This pilot study includes pregnant women at high risk (smoking at ...

Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at ...

Selenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants in 154 genes ...

Background: The prevalence of suicidal behaviour among adolescents are high, and act as a risk factor of suicide. Suicide is considered a public health problem worldwide. Indigenous people are in general at higher risk of suicide than the majority population, and there are gender differences in the pathways of suicidal behaviour and suicides. Objectives: To investigate the association and importance ...

<i>Background</i>: Despite the increasing prevalence of diabetes and increasing use of electronic health (eHealth) among people with diabetes, little is known about the association between the use of eHealth and the use of provider-based health services.<p> <p><i>Objective</i>: The objective of this study was to investigate whether the use of eHealth might change patients’ decisions regarding ...

<i>Background</i>: Managing a chronic condition takes work, and it is considered important that patients carry out this work. However, knowledge is lacking on what elements enhance self-management work. Persons with food hypersensitivity (FH) seem to do self-management work despite the relatively little support they receive. Our aim is to explore what makes women with FH carry out the work of ...

<p><i>BACKGROUND - </i>The clinical presentation of gastroesophageal reflux disease (GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders. <p><i>AIM - </i>To prospectively ...

<p><i>Background - </i>Recruitment and inclusion procedures in clinical trials are time critical. This holds particularly true for studies investigating patients with fluctuating symptom patterns, like those with chronic neck pain. In a feasibility study on neck pain, we found a clinically relevant decrease in pain ratings within the recruitment period. This paper analyses the phenomenon and gives ...

Denne rapporten er skrevet som del av sluttrapporteringen av prosjektet Recruit & Retain – Making it Work. Prosjektet er støttet av EU-programmet The Northern Perifery and Arctic Program (http://www.interreg-npa.eu) og har gått over tre år fra februar 2016 til januar 2019. Hovedmålsettingen med prosjektet har vært å finne fram til modeller for å arbeide systematisk med rekruttering og stabilisering ...

Background: Drug policies in western countries, as well as countries in most other parts of the world, support self-medication with Over-The-Counter (OTC) drugs. The switch from prescription (Rx)-to-OTC has been most common in the Nordic countries, Great Britain and Germany in the last decades and deregulations were done to make it possible to sell OTC analgesics other places than under the pharmacy ...