Despite advances in therapies, assessment of fracture risk, and diagnosis of bone fragility, few women and men with high fracture risk receive treatment, even after they develop fracture. To be able to recognize and identify subjects who are at risk for fragility fracture, and to target treatment well, it is important to search for risk factors that are associated with, or ideally, predict fracture. ...

Mange gjennomgår et hjerteinfarkt uten å vite at det har skjedd, dette kalles stumme hjerteinfarkt. Det er ikke kjent hvorfor noen rammes av stumme hjerteinfarkt, mens andre opplever brystsmerter og tar kontakt med lege. I Tromsøundersøkelsens 6.runde ble 6,199 personer undersøkt med EKG, der man kan se om en person har gjennomgått et hjerteinfarkt. I tillegg ble det samlet inn data på smertefølsomhet ...

A method of calculating positive predictive values (PPVs) and likelihood ralios (LRs) on the basis of Bayesian probabilities has been described previously. In the present article the method is applied to a sore which does not heal in relation to skin cancer, a lump in the breast in relation to female breast cancer, genital bleeding in relation to internal genital cancer in fernales and ...

Background: The possible relationships between age at menarche and total as well as cardiovascular mortality has been investigated, but has not been established. Aim: The first aim was to investigate the reproducibility of self-reported menarcheal age from 1986-1987 (Tromsø 3) to 1994-1995 (Tromsø 4). The second aim was to examine the association between age at menarche and cardiovascular- or ...

Prior calculation of the sex- and age-distributed positive predictive value (PPV) of a symptom in relation to a disease forms the basis for probability revision based on new information about signals observed during the medical encounter: a symptom, a sign, a piece of information based on the medical history, a laboratory test. Probability revision requires estimates of sensitivity and specificity ...

There is an increasing evidence that health‐related quality of life, income, and social relationships are important to our subjective well‐being (SWB). Little is known, however, about the specific indirect pathways that link health to SWB via social relationships and income. On the basis of a unique data set of 7 disease groups from 6 OECD‐countries (N = 6,173), we investigate the direct and indirect ...

Purpose: <br>Sun exposure is associated with risk of several chronic diseases including cancer. The study aim is to investigate whether sun behaviours are related to other lifestyle risk factors of cancer. <br> Methods: <br>We analysed data collected in 2003-2004 by self-completed questionnaire from 34,402 Swedish women aged 40-61 years, who comprised 70% of a cohort of originally recruited from ...

Few studies have investigated the association between endometrial cancer and physical activity (PA) using repeated measures of PA and different subtypes of endometrial cancer. We aimed to investigate the association between endometrial cancer and PA level at two points in time in women with different body mass index (BMI) profiles, and to calculate the population attributable fraction (PAF) of ...

Background: <br> The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. <br> ...

The aim of our study was to assess associations between smoking behavior before and during pregnancy and selected adverse birth outcomes. This study is based on the Murmansk County Birth Registry (MCBR). Our study includes women who delivered a singleton pregnancy after 37 weeks of gestation (N = 44,486). Smoking information was self-reported and assessed at the first antenatal visit during pregnancy. ...