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dc.contributor.authorAppenroth, Daniel
dc.contributor.authorWest, Alexander Christopher
dc.contributor.authorWood, Shona Hiedi
dc.contributor.authorHazlerigg, David Grey
dc.date.accessioned2024-11-01T09:40:15Z
dc.date.available2024-11-01T09:40:15Z
dc.date.issued2024-09-20
dc.description.abstractIn mammals and birds, tanycytes are known to regulate thyroid hormone conversion, and this process is central to the control of seasonal reproduction. In mammals, this cell type is also implicated in retinoic acid signalling, neurogenesis, and nutritional gatekeeping, all of which have been linked to hypothalamic regulation of energy metabolism. Less is known about these potential wider roles of tanycytes in birds. To address this gap, we combined LASER capture microdissection and transcriptomics to profile the tanycytic region in male Svalbard ptarmigan, a High Arctic species with photoperiod-dependent seasonal rhythms in reproductive activation and body mass. Short photoperiod (SP) adapted birds were transferred to constant light (LL) to trigger breeding and body mass loss. After five months under LL, the development of photorefractoriness led to spontaneous re-emergence of the winter phenotype, marked by the termination of breeding and gain in body mass. The transfer from SP to LL initiated gene expression changes in both thyroid hormone and retinoic acid pathways, as described in seasonal mammals. Furthermore, transcriptomic signatures of cell differentiation and migration were observed. Comparison to data from Siberian hamsters demonstrated that a photoperiod-dependent re-organisation of the hypothalamic tanycytic region is likely a conserved feature. Conversely, the spontaneous development of photorefractoriness showed a surprisingly small number of genes that reverted in expression level, despite reversal of the reproductive and metabolic phenotype. Our data suggest general conservation of tanycyte biology between photoperiodic birds and mammals and raise questions about the mechanistic origins of the photorefractory state.en_US
dc.identifier.citationAppenroth, West, Wood, Hazlerigg. Tanycytes from a bird’s eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan. Journal of Comparative Physiology A. Sensory, neural, and behavioral physiology. 2024en_US
dc.identifier.cristinIDFRIDAID 2308755
dc.identifier.doi10.1007/s00359-024-01716-3
dc.identifier.issn0340-7594
dc.identifier.issn1432-1351
dc.identifier.urihttps://hdl.handle.net/10037/35390
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalJournal of Comparative Physiology A. Sensory, neural, and behavioral physiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleTanycytes from a bird’s eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmiganen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)