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dc.contributor.advisorYtrehus, Kirsti
dc.contributor.advisorLund, Trine
dc.contributor.authorAljabri, Mohammad Belal
dc.date.accessioned2011-08-22T06:30:43Z
dc.date.available2011-08-22T06:30:43Z
dc.date.issued2011-05-26
dc.description.abstractIn this thesis different factors that promote or inhibit heart remodelling induced by angiotensin II were studied. The following conclusions can be drawn: 1. The presence of elevated levels of Ang II in the perfusion buffer did not increase myocardial injury during ischemia-reperfusion. However, the ability to protect the heart by ischemic postconditioning was lost. This seemed to be due to blockade of ERK1/2 signalling and GSK3-β inhibition induced by postconditioning. Elevated levels of Ang II, which is seen in untreated cardiovascular disease and in kidney disease, could therefore contribute to limit the outcome of the potential clinical use of postconditioning. 2. Non-compensatory (non-hypertrophic) heart remodelling was triggered by high-dose Ang II. This leads to changes in the contractile apparatus and reduced tolerance to ischemia in the absence of cellular hypertrophy. Increased expression of key genes involved in fibrosis was followed by an increase in interstitial fibrosis in heart tissue, which partly explains the post ischemic diastolic dysfunction. 3. Pregnancy did protect against the detrimental effects of Ang II since cardiac remodelling, fibrosis and reduced vessel density were less prominent in pregnant rats. 4. Iso treatment induced heart hypertrophy in both genders, but increased fibrosis was found only in males. Unlike the situation with exposure to high concentrations of Ang II, female gender did protect against the increase in fibrosis after Iso treatment. In summary, we can conclude that female gender and the unique female physiological status of pregnancy protect the heart, and provide a better handling of various stress stimuli after moderate Ang II and β-adrenergic influence. When the angiotensin II exposure reaches sub-toxic levels the protection afforded by female gender is lost.en
dc.description.doctoraltypeph.d.en
dc.descriptionPapers number 1, 3 and 4 of this thesis are not available in Munin: <br/>1. M. B. Aljabri , T. Lund, T. V. Andreasen and K. Ytrehus: 'Angiotensin II abates the beneficial effects of postconditioning in ERK and GSK- 3β dependent manner' (submitted paper) <br/>3. M. B. Aljabri, N. T. Songstad, T. Lund, M. C. Serrano, T. V. Andreasen, S. Al-Saad, S. Lindal, V. Sitras, G. Acharya, K. Ytrehus: 'Pregnancy protects against antiangiogenic and fibrogenic effects of angiotensin II in rat hearts', Acta Physiologica (Oxf) (2011) Apr;201(4):445-56. Available at <a href=http://dx.doi.org/10.1111/j.1748-1716.2010.02234.x>http://dx.doi.org/10.1111/j.1748-1716.2010.02234.x</a> <br/>4. M. B. Aljabri , T. Lund, S. Al-Saad, J. Benjaminsen, T. V. Andreasen and K. Ytrehus: 'Chronic isoproterenol treatment enhances extracellular fibrosis and postischemic diastolic dysfunction in male but not female rat heart' (manuscript)en
dc.identifier.isbn978-82-7589-308-4
dc.identifier.urihttps://hdl.handle.net/10037/3555
dc.identifier.urnURN:NBN:no-uit_munin_3276
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2011 The Author(s)
dc.subjectVDP::Humanities: 000::Movie and drama: 170::Movie science: 171en
dc.subjectVDP::Humaniora: 000::Film- og teatervitenskap: 170::Filmvitenskap: 171en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Human and veterinary science physiology: 718en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Human og veterinærmedisinsk fysiologi: 718en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Physiopathology: 721en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Patofysiologi: 721en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Toxicology: 730en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Toksikologi: 730en
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en
dc.titleAngiotensin II and heart remodelling : role of ischemia, gender and pregnancyen
dc.typeDoctoral thesisen
dc.typeDoktorgradsavhandlingen


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