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dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorWinberg, Jan-Olof
dc.contributor.authorReinholt, Finn P.
dc.contributor.authorLarsen, Terje
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorBerg, Eli
dc.contributor.authorKolset, Svein Olav
dc.date.accessioned2012-03-07T12:14:33Z
dc.date.available2012-03-07T12:14:33Z
dc.date.issued2011
dc.description.abstractDb/db mice are overweight, dyslipidemic and develop diabetic complications, relevant for similar complications in human type 2 diabetes. We have used db/db and db/+ control mice to investigate alterations in proteinase expression and activity in circulation and kidneys by SDS-PAGE zymography, electron microscopy, immunohistochemistry, Western blotting, and in situ zymography. Plasma from db/db mice contained larger amounts of serine proteinases compared to db/+ mice. Kidneys from the db/db mice had a significantly larger glomerular surface area and somewhat thicker glomerular basement membranes compared to the db/+ mice. Furthermore, kidney extracts from db/+ mice contained metalloproteinases with Mr of approximately 92000, compatible with MMP-9, not observed in db/db mice. These results indicate that higher levels of serine proteinases in plasma may serve as potential markers for kidney changes in db/db mice, whereas a decrease in MMP-9 in the kidney may be related to the glomerular changes.en
dc.identifier.citationISRN Endocrinology (2011), Article ID 832642, 10 pagesen
dc.identifier.cristinIDFRIDAID 845725
dc.identifier.doidoi: 10.5402/2011/832642
dc.identifier.issn2090-4630
dc.identifier.urihttps://hdl.handle.net/10037/3913
dc.identifier.urnURN:NBN:no-uit_munin_3635
dc.language.isoengen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical biochemistry: 726en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726en
dc.titleProteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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