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dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorValkov, Andrey Yurjevich
dc.contributor.authorDønnem, Tom
dc.contributor.authorSmeland, Eivind
dc.contributor.authorAl-Shibli, Khalid Ibrahim
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.date.accessioned2012-03-12T10:25:00Z
dc.date.available2012-03-12T10:25:00Z
dc.date.issued2011
dc.description.abstractThe purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting roles during cancer development. Tissue microarrays from 249 patients with STS were constructed from duplicate cores of viable and representative neoplastic tumor areas. Immunohistochemistry was used to evaluate the CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in tumors. In univariate analyses, increased numbers of CD4+ (P = 0.008) and CD20+ (P = 0.006) lymphocytes in tumor correlated significantly with an improved disease-specific survival (DSS) in patients with wide resection margins (n = 108). In patients with non-wide resection margins (n = 141) increased numbers of CD3+ (P = 0.028) lymphocytes in tumor correlated significantly with shorter DSS. In multivariate analyses, a high number of CD20+ lymphocytes (HR = 5.5, CI 95% = 1.6–18.6, P = 0.006) in the tumor was an independent positive prognostic factor for DSS in patients with wide resections margins. High density of CD20+ lymphocytes in STS with wide resection margins is an independent positive prognostic indicator for these patients. Further research is needed to define if CD20+ cells can modify tumors in a way that reduces disease progression and metastatic potential.en
dc.descriptionThis paper is part of Sveinung Sørbye's doctoral thesis, available in Munin at <a href=http://hdl.handle.net/10037/5478>http://hdl.handle.net/10037/5478</a>
dc.identifier.citationPLoS ONE (2011) 6(1): e14611en
dc.identifier.cristinIDFRIDAID 837237
dc.identifier.doidoi: 10.1371/journal.pone.0014611
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/3928
dc.identifier.urnURN:NBN:no-uit_munin_3650
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titlePrognostic Impact of Lymphocytes in Soft Tissue Sarcomasen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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