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dc.contributor.authorSteffensen, Linn Hofsøy
dc.contributor.authorJørgensen, Lone
dc.contributor.authorStraume, Bjørn
dc.contributor.authorMellgren, Svein Ivar
dc.contributor.authorKampman, Margitta Theodora
dc.date.accessioned2012-03-14T09:08:43Z
dc.date.available2012-03-14T09:08:43Z
dc.date.issued2011
dc.description.abstractMultiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this double-blinded trial. Participants were randomised to receive 20,000 IU vitamin D3 or placebo once a week and 500 mg calcium daily for 96 weeks. The primary outcome was the effect of the intervention on percentage change in bone mineral density (BMD) at the hip, the spine, and the ultradistal radius over the study period. Of 71 participants randomised, 68 completed. Mean serum 25-hydroxyvitamin D [25(OH)D] levels in the intervention group increased from 55 nmol/L at baseline to 123 nmol/L at week 96. After 96 weeks, percentage change in BMD did not differ between groups at any site. BMD decreased at the hip, by 1.4% in the placebo group (95% CI -2.3 to -0.4, SD 2.7, p = 0.006) and by 0.7% in the treatment group (-1.6 to 0.2, 2.7, p = 0.118), difference 0.7% (-1.9 to 0.7, p = 0.332). Findings were not altered by adjustment for sex or serum 25(OH)D. Supplementation with 20,000 IU vitamin D3 a week did not prevent bone loss in this small population. Larger studies are warranted to assess the effect of vitamin D on bone health in persons with MS.en
dc.identifier.citationJournal of Neurology 258(2011) nr. 9 s. 1624-1631en
dc.identifier.cristinIDFRIDAID 847286
dc.identifier.doidoi: 10.1007/s00415-011-5980-6
dc.identifier.issn0340-5354
dc.identifier.urihttps://hdl.handle.net/10037/3956
dc.identifier.urnURN:NBN:no-uit_munin_3678
dc.language.isoengen
dc.publisherSpringer Verlagen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical biochemistry: 726en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726en
dc.titleCan vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trialen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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