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Now showing items 626-645 of 10096
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Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)Objectives:<br>Among patients with severe aortic stenosis (AS), we investigated the associations of N–terminal pro–natriuretic peptide (NT–proBNP), high–sensitive troponin T (hsTnT), and high–sensitive C–reactive protein (hs–CRP) with 3–year mortality and major adverse cardiovascular events (MACE) during 1 year.<br>Methods:<br>This observational cohort study prospectively enrolled 442 patients with ... -
Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)INTRODUCTION - Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).<p> <p>METHODS - We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = ... -
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-06)Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N).<p> <p>Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents ... -
Associations of widespread pain sensitivity, comorbid chronic pain and psychological distress with Irritable Bowel Syndrome and abdominal pain
(Doctoral thesis; Doktorgradsavhandling, 2014-09-25)This is the first report documenting widespread hyperalgesia among adolescent and adult individuals with symptoms of IBS in the general population. Results were found to be independent of sex, comorbid pain and psychological distress. Increased pain sensitivity may contribute in triggering and maintaining chronic pain, but prospective studies are needed to examine these possible causal relationships. The ... -
Associations with antibiotic prescribing for acute exacerbation of COPD in primary care: Secondary analysis of a randomised controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)<i>Background</i> - C-reactive protein (CRP) point-of-care testing can reduce antibiotic use in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in primary care, without compromising patient care. Further safe reductions may be possible.<br><br> <i>Aim</i> - To investigate the associations between presenting features and antibiotic prescribing in patients with ... -
Associations with Post-Consultation Health-Status in Primary Care Managed Acute Exacerbation of COPD
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-16)Background: It has been demonstrated that antibiotic prescribing for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) can be safely reduced in primary care when general practitioners have access to C-reactive protein (CRP) rapid testing.<p> <p>Aim: To investigate the factors associated with post-consultation COPD health status in patients presenting with AECOPD in this sett ... -
Assosiasjon mellom erfaring med vold og muskel-skjelettplager og psykisk helse i en generell populasjon. En studie basert på Tromsøundersøkelsen
(Master thesis; Mastergradsoppgave, 2013-05-04)Bakgrunn: Flere internasjonale studier viser at traumatiske opplevelser i barndom og voksen alder er assosiert med utvikling av dårlig helse på mange områder. Årsakene eller begrunnelsene for disse sammenhengene er fortsatt ikke godt nok forstått. Hensikten med denne studien er å undersøke assosiasjonen mellom psykisk eller fysisk vold – i barndom og voksen alder- og selv rapportert psykisk helse ... -
Assosiasjon mellom lungefunksjon og kognitive evner hos friske ungdommer
(Master thesis; Mastergradsoppgave, 2014-05-02)Sammendrag En rekke studier har rapportert en assossiasjon mellom pustemekanismer og kognitiv funksjon hos voksne og eldre. Hvorvidt denne sammenhengen også gjelder for yngre individ er ennå ikke fullt utforsket. Vi ville med denne studien undersøke dette nærmere, ved å sammenligne en tenåringsgruppe med en ung voksen gruppe. Vi har brukt ulike lungemål for å se om de var relatert til kognitive ... -
Assosiasjoner mellom individuelle- og livsstilsfaktorer og kognitiv funksjon hos friske eldre
(Mastergradsoppgave; Master thesis, 2021-12-14)Hensikten med denne studien var å undersøke om det er en assosiasjon mellom ulike individuelle- og livsstilsfaktorer og kognitiv funksjon hos friske eldre. Antallet eldre i verden og i Norge har økt drastisk de siste årene, og det predikeres at dette vil fortsette å øke. Aldring er assosiert med en rekke kognitive endringer og svekkelser, samt økt risiko for sykdommen demens. Det finnes ingen ... -
Asthma and allergy in children : an epidemiological study of asthma and allergy in schoolchildren living in Northern Norway and Russia with respect to prevalence trends 1985-1995-2000, geographic differences in prevalence and biomarkers
(Doctoral thesis; Doktorgradsavhandling, 2006)The thesis has focused on asthma, AR and AD in children in a limited geographical region over a limited period of time and has studied the prevalence trends, geographical differences in prevalence and the biomarker s-ECP. These are the main findings in the five papers published: <ul id = «mylist»> <li> The prevalence of asthma and allergy in north Norwegian primary schoolchildren increased ... -
Asthma,chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)To describe symptoms and lung function in patients registered with asthma or chronic obstructive pulmonary disease (COPD) in primary care and to examine how spirometry findings fit with general practitioners’ (GPs) diagnoses. Patients aged ≥40 years with a diagnosis of asthma or COPD registered in the electronic medical record during the previous 5 years were recruited at seven GP offices in Norway ... -
Astma : en utfordring i tiden.
(Master thesis; Mastergradsoppgave, 2008-09)Sammendrag Introduksjon: Astma er en av de hyppigst kroniske sykdommene i verden, og de siste årene har forekomsten økt betydelig. Sykdommen er en betydelig samfunnsøkonomisk og helsemessig belastning som enhver lege før eller siden må forholde seg til. Materiale og metode: Oppgaven er todelt. Den består av et litteraturstudium hvor vi har tatt for oss eksisterende retningslinjer for ... -
ATAD3 proteins in autophagy. Do ATAD3 proteins have a direct role in regulating autophagy
(Master thesis; Mastergradsoppgave, 2020-05-22)ATPase Family AAA Domain -containing protein 3 (ATAD3) is a nuclear-encoded mitochondrial transmembrane protein encompassing three isoforms; ATAD3A, ATAD3B and ATAD3C. ATAD3 is involved in several cellular process and available data predict that ATAD3A and ATAD3B proteins may have potential roles in regulating autophagy and mitophagy. Preliminary data from our research group identified interactions ... -
Aterosklerose synes å være sterkere relatert til kortikale enn til lakunære hjerneinfarkt
(Master thesis; Mastergradsoppgave, 2002-09) -
Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses—the ComIT-1 trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)The introduction of immune checkpoint inhibitors has transformed the treatment landscape of metastatic non-small cell lung cancer. However, challenges remain to increase the fraction of patients achieving durable clinical responses to these drugs and to help monitor the treatment effect. In this phase II trial, we investigated the toxicity, systemic responses and circulating tumour DNA responses in ... -
ATG8 Family Proteins Act as Scaffolds for Assembly of the ULK Complex SEQUENCE REQUIREMENTS FOR LC3-INTERACTING REGION (LIR) MOTIFS
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-10-05)Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101. We have used pulldown and peptide array overlay assays to ... -
Atg8 family proteins, LIR/AIM motifs and other interaction modes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-19)The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, ... -
ATG9A protects the plasma membrane from programmed and incidental permeabilization.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)The integral membrane protein ATG9A plays a key role in autophagy. It displays a broad intracellular distribution and is present in numerous compartments, including the plasma membrane (PM). The reasons for the distribution of ATG9A to the PM and its role at the PM are not understood. Here, we show that ATG9A organizes, in concert with IQGAP1, components of the ESCRT system and uncover cooperation ... -
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ... -
The ATLET study: Can subjects with long-standing motor incomplete spinal cord injury learn to walk? A randomized clinical trial
(Doctoral thesis; Doktorgradsavhandling, 2020-05-19)Body-weight supported locomotor training (BWSLT) has been used to improve walking function in subjects with incomplete Spinal Cord Injuries (SCI), but randomized controlled trials (RCTs) among subjects with long-standing (>2 years) incomplete SCI and poor walking function are scarce. This research aims to describe the methodology and report the results from two parallel, but independent, single-blinded ...
