Blar i forfatter Det helsevitenskapelige fakultet "Kaaks, Rudolf"

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    • Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies 

      Nichols, Hazel B.; Schoemaker, Minouk J.; Cai, Jianwen; Xu, Jiawei; Wright, Lauren B.; Brook, Mark N.; Jones, Michael E.; Adami, Hans Olov; Baglietto, Laura; Bertrand, Kimberly A.; Blot, William J.; Boutron-Ruault, Marie-Christine; Dorronsoro, Miren; Dossus, Laure; Eliassen, A. Heather; Giles, Graham G.; Gram, Inger Torhild; Hankinson, Susan E.; Hoffman-Bolton, Judy; Kaaks, Rudolf; Key, Timothy J.; Kitahara, Cari M.; Larsson, Susanna C.; Linet, Martha; Merritt, Melissa A.; Milne, Roger L.; Pala, Valeria; Palmer, Julie R.; Peeters, Petra H.; Riboli, Elio; Sund, Malin; Tamimi, Rulla M.; Tjønneland, Anne; Trichopoulou, Antonia; Ursin, Giske; Vatten, Lars Johan; Visvanathan, Kala; Weiderpass, Elisabete; Wolk, Alicja; Zheng, Wei; Weinberg, Clarice R.; Swerdlow, Anthony J.; Sandler, Dale P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)
      <i>Background</i>: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated.<p> <p><i>Objective</i>: To characterize breast cancer risk in relation to recent childbirth.<p> <p>Design</i> : Pooled ...

    • Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses 

      Dimou, Niki; Omiyale, Wemimo; Biessy, Carine; Viallon, Vivian; Kaaks, Rudolf; O'Mara, Tracy A.; Aglago, Elom K.; Ardanaz, Eva; Bergmann, Manuela M.; Bondonno, Nicola P.; Braaten, Tonje; Colorado-Yohar, Sandra M.; Crous-Bou, Marta; Dahm, Christina C.; Fortner, Renée T.; Gram, Inger Torhild; Harlid, Sophia; Heath, Alicia K.; Idahl, Annika; Kvaskoff, Marina; Nøst, Therese Haugdahl; Overvad, Kim; Palli, Domenico; Perez-Cornago, Aurora; Sacerdote, Carlotta; Sánchez, Maria-Jose; Schulze, Matthias B.; Severi, Gianluca; Simeon, Vittorio; Tagliabue, Giovanna; Tjønneland, Anne; Truong, Thérése; Tumino, Rosario; Johansson, Mattias; Weiderpass, Elisabete; Murphy, Neil; Gunter, Marc J.; Lacey, Ben; Allen, Naomi E.; Dossus, Laure (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-16)
      Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.<p> <p>Methods: The observational analyses included 286,415 ...

    • Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts 

      Rothwell, Joseph A.; Bešević, Jelena; Dimou, Niki; Breeur, Marie; Murphy, Neil; Jenab, Mazda; Wedekind, Roland; Viallon, Vivian; Ferrari, Pietro; Achaintre, David; Gicquiau, Audrey; Rinaldi, Sabina; Scalbert, Augustin; Huybrechts, Inge; Prehn, Cornelia; Adamski, Jerzy; Cross, Amanda J.; Keun, Hector; Chadeau-Hyam, Marc; Boutron-Ruault, Marie-Christine; Overvad, Kim; Dahm, Christina C.; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Skeie, Guri; Zamora-Ros, Raul; Tsilidis, Kostas K.; Eichelmann, Fabian; Schulze, Matthias B.; van Guelpen, Bethany; Vidman, Linda; Sánchez, Maria-José; Amiano, Pilar; Ardanaz, Eva; Smith-Byrne, Karl; Travis, Ruth; Katzke, Verena; Kaaks, Rudolf; Derksen, Jeroen W. G.; Colorado-Yohar, Sandra; Tumino, Rosario; Bueno-de-Mesquita, Bas; Vineis, Paolo; Palli, Domenico; Pasanisi, Fabrizio; Eriksen, Anne Kirstine; Tjønneland, Anne; Severi, Gianluca; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-28)
      Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulat‑ ing levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank ...

    • Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival 

      Johansson, Mattias; Anouar, Fanidi; Muller, David C.; Bassett, Julie K.; Midttun, Øivind; Vollset, Stein Emil; Travis, Ruth C.; Palli, Domenico; Mattiello, Amalia; Sieri, Sabina; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Ljungberg, Börje; Hallmans, Göran; Weiderpass, Elisabete; Skeie, Guri; Gonzalez, Carlos A.; Dorronsoro, Miren; Peeters, Petra H.; Bueno-de-Mesquita, H. B(as).; Ros, Martine M.; Ruault, Marie-Christine Boutron; Fagherazzi, Guy; Clavel, Françoise; Sanchez, Maria-Jose; Gurrea, Aurelio Barricarte; Navarro, Carmen; Quirós, J. Ramón; Overvad, Kim; Tjønneland, Anne; Aleksandrova, Krassimira; Vineis, Paolo; Gunter, Marc J.; Kaaks, Rudolf; Giles, Graham; Relton, Caroline; Riboli, Elio; Boeing, Heiner; Ueland, Per Magne; Severi, Gianluca; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-05)
      The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. ...

    • Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia 

      Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; Smith-Byrne, Karl; Noor, Urwah; Andrews, Colm D.; Gunter, Marc J.; Holmes, Michael V.; Martin, Richard M.; Tsilidis, Konstantinos K.; Albanes, Demetrius; Barricarte, Aurelio; Bueno-de-Mesquita, Bas; Chen, Chu; Cohn, Barbara A.; Dimou, Niki L.; Ferrucci, Luigi; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward L.; Goodman, Gary E.; Haiman, Christopher A.; Hankey, Graeme J.; Huang, Jiaqi; Huang, Wen-Yi; Hurwitz, Lauren M.; Kaaks, Rudolf; Knekt, Paul; Kubo, Tatsuhiko; Langseth, Hilde; Laughlin, Gail; Le Marchand, Loic; Luostarinen, Tapio; MacInnis, Robert J.; Mäenpää, Hanna O.; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Mucci, Lorelei A.; Olsen, Anja; Ozasa, Kotaro; Palli, Domenico; Penney, Kathryn L.; Platz, Elizabeth A.; Rissanen, Harri; Sawada, Norie; Schenk, Jeannette M.; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Tsai, Chiaojung Jillian; Tsugane, Shoichiro; Vatten, Lars Johan; Weiderpass, Elisabete; Weinstein, Stephanie J.; Wilkens, Lynne R.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-17)
      Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate ...

    • Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort 

      Cairat, Manon; Rinaldi, Sabina; Navionis, Anne-Sophie; Romieu, Isabelle; Biessy, Carine; Viallon, Vivian; Olsen, Anja; Tjønneland, Anne; Fournier, Agnès; Severi, Gianluca; Kvaskoff, Marina; Fortner, Renée T.; Kaaks, Rudolf; Aleksandrova, Krasimira; Schulze, Matthias B.; Masala, Giovanna; Tumino, Rosario; Sieri, Sabina; Grasso, Chiara; Mattiello, Amalia; Gram, Inger Torhild; Olsen, Karina Standahl; Agudo, Antonio; Etxezarreta, Pilar Amiano; Sánchez, Maria-Jose; Santiuste, Carmen; Barricarte, Aurelio; Monninkhof, Evelyn; Hiensch, Anouk E.; Muller, David; Merritt, Melissa A.; Travis, Ruth C.; Gunter, Marc J.; Dossus, Laure; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-18)
      Background: Infammation has been hypothesized to play a role in the development and progression of breast can‑ cer and might diferently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 ...

    • Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition 

      Bradbury, Kathryn E.; Appleby, Paul N.; Tipper, Sarah J.; Travis, Ruth C.; Allen, Naomi E.; Kvaskoff, Marina; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Cervenka, Iris; Mahamat-Saleh, Yahya; Bonnet, Fabrice; Kaaks, Rudolf; Fortner, Renée T.; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Stratigos, Alexander J.; Palli, Domenico; Grioni, Sara; Matullo, Giuseppe; Panico, Salvatore; Tumino, Rosario; Peeters, Petra H.; Bueno-de-Mesquita, H. Bas; Ghiasvand, Reza; Veierød, Marit B.; Weiderpass, Elisabete; Bonet, Catalina; Molina, Elena; Huerta, José M.; Larrañaga, Nerea; Barricarte, Aurelio; Merino, Susana; Isaksson, Karolin; Stocks, Tanja; Ljuslinder, Ingrid; Hemmingsson, Oskar; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc J.; Rinaldi, Sabina; Tsilidis, Konstantinos K.; Aune, Dagfinn; Riboli, Elio; Key, Timothy J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-07)
      Insulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations ...

    • Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements 

      Smith-Byrne, Karl; Cerani, Agustin; Guida, Florence; Zhou, Sirui; Agudo, Antonio; Aleksandrova, Krasimira; Barricarte, Aurelio; Barranco, Miguel Rodríguez; Bochers, Christoph H.; Gram, Inger Torhild; Han, Jun; Amos, Christopher I.; Hung, Rayjean J.; Grankvist, Kjell; Nøst, Therese Haugdahl; Imaz, Liher; Chirlaque-López, María Dolores; Johansson, Mikael; Kaaks, Rudolf; Kühn, Tilman; Martin, Richard M.; McKay, James D.; Pala, Valeria; Robbins, Hilary A.; Sandanger, Torkjel M; Schibli, David; Schulze, Matthias B.; Travis, Ruth C.; Vineis, Paolo; Weiderpass, Elisabete; Brennan, Paul; Johansson, Mattias; Richards, J Brent (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-04)
      Background: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies.<p> <p>Materials and Methods: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide association studies (GWAS) of blood ...

    • Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort 

      van Roekel, Eline H.; Trijsburg, Laura; Assi, Nada; Carayol, Marion; Achaintre, David; Murphy, Neil; Rinaldi, Sabina; Schmidt, Julie A.; Stepien, Magdalena; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Iqbal, Khalid; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Ricceri, Fulvio; Panico, Salavatore; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Ardanaz, Eva; Lujan-Barroso, Leila; Quirós, José Ramón; Huerta, José María; Molina-Portillo, Elena; Dorronsoro, Miren; Tsilidis, Konstantinos K.; Riboli, Elio; Rostgaard-Hansen, Agnetha Linn; Tjønneland, Anne; Overvad, Kim; Weiderpass, Elisabete; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Trichopoulou, Antonia; Karakatsani, Anna; Kotanidou, Anastasia; Håkansson, Anders; Malm, Johan; Weijenberg, Matty P.; Gunter, Marc J.; Jenab, Mazda; Johansson, Mattias; Travis, Ruth C.; Scalbert, Augustin; Ferrari, Pietro (Journal article; Peer reviewed, 2018-05-22)
      Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at ...

    • Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype: Results from the EPIC cohort. 

      Sarink, Danja; Schock, Helena; Johnson, Theron; Overvad, Kim; Holm, Marianne; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; His, Mathilde; Kvaskoff, Marina; Boeing, Heiner; Lagiou, Pagona; Papatesta, Eleni-Maria; Trichopoulou, Antonia; Palli, Domenico; Pala, Valeria; Mattiello, Amalia; Tumino, Rosario; Sacerdote, Carlotta; Bueno-De-Mesquita, Hendrik Bastiaan; van Gils, Carla H.; Peeters, Petra H.; Weiderpass, Elisabete; Agudo, Antonio; Sánchez, María-José; Chirlaque, Maria-Dolores; Ardanaz, Eva; Amiano, Pilar; Khaw, Kay Tee; Travis, Ruth; Dossus, Laure; Gunter, Mark; Rinaldi, Sabina; Merritt, Melissa; Riboli, Elio; Kaaks, Rudolf; Fortner, Renée T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-31)
      Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has ...

    • Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study 

      Bhoo-Pathy, Nirmala; Peeters, Petra; Uiterwaal, Cuno S.P.M.; Bueno-de-Mesquita, H. Bas; Bulgiba, Awang M.; Bech, Bodil Hammer; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Perquier, Florence; Teucher, Birgit; Kaaks, Rudolf; Schütze, Madlen; Boeing, Heiner; Lagiou, Pagona; Orfanos, Philippos; Trichopoulou, Antonia; Agnoli, Claudia; Mattiello, Amalia; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; van Duijnhoven, Fränzel J.B.; Braaten, Tonje; Lund, Eiliv; Skeie, Guri; Redondo, María-Luisa; Buckland, Genevieve; Perez, Maria José Sánches; Chirlaque, Maria-Dolores; Ardanaz, Eva; Amiano, Pilar; Wirfält, Elisabet; Wallström, Peter; Johansson, Ingegerd; Nilsson, Maria; Khaw, Kay-Tee; Wareham, Nick; Allen, Naomi E.; Key, Timothy J; Rinaldi, Sabina; Romieu, Isabelle; Gallo, Valentina; Riboli, Elio; Van Gils, Carla H (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
      Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.<p> <p>Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary ...

    • Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition 

      Caini, Saverio; Masala, Giovanna; Saieva, Calogero; Kvaskoff, Marina; Savoye, Isabelle; Sacerdote, Carlotta; Hemmingsson, Oskar; Hammer Bech, Bodil; Overvad, Kim; Tjønneland, Anne; Petersen, Kristina E.N.; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Cervenka, Iris; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Floegel, Anna; Trichopoulou, Antonia; Valanou, Elisavet; Kritikou, Maria; Tagliabue, Giovanna; Panico, Salvatore; Tumino, Rosario; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Veierød, Marit Bragelien; Ghiasvand, Reza; Lukic, Marko; Quirós, José Ramón; Chirlaque, Maria-Dolores; Ardanaz, Eva; Salamanca Fernández, Elena; Larrañaga, Nerea; Zamora-Ros, Raul; Maria Nilsson, Lena; Ljuslinder, Ingrid; Jirström, Karin; Sonestedt, Emily; Key, Timothy J.; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Huybrechts, Inge; Murphy, Neil; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Palli, Domenico (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-20)
      In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC ...

    • Combined impact of healthy lifestyle factors on colorectal cancer: A large European cohort study 

      Aleksandrova, Krasimira; Pischon, Tobias; Jenab, Mazda; Bueno-de-Mesquita, Bas H; Fedirko, Veronika; Norat, Teresa; Romaguera, Dora; Knüppel, Sven; Boutron-Ruault, Marie-Christine; Dossus, Laure; Dartois, Laureen; Kaaks, Rudolf; Li, Kuanrong; Tjønneland, Anne; Overvad, Kim; Quirós, José Ramón; Buckland, Genevieve; Sanchez, Maria Jose; Dorronsoro, Miren; Chirlaque, Maria-Dolores; Barricarte, Aurelio; Khaw, Kay-Tee; Wareham, Nicholas J; Bradbury, Kathryn E; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Siersema, Peter D.; Peeters, Petra HM; Ljuslinder, Ingrid; Johansson, Ingegerd; Ericson, Ulrika; Ohlsson, Bodil; Weiderpass, Elisabete; Skeie, Guri; Borch, Kristin Benjaminsen; Rinaldi, Sabina; Romieu, Isabelle; Kong, Joyce; Gunter, Marc J; Ward, Heather A; Riboli, Elio; Boeing, Heiner (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Combined Impact of Lifestyle Factors on Prospective Change in Body Weight and Waist Circumference in Participants of the EPIC-PANACEA Study 

      May, Anne M.; Romaguera, Dora; Travier, Noémie; Ekelund, Ulf; Bergmann, Manuela M.; Kaaks, Rudolf; Teucher, Birgit; Steffen, Annika; Boeing, Heiner; Halkjaer, Jytte; Tjonneland, Anne; Jakobsen, Marianne Uhre; Overvad, Kim; Dartois, Laureen; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Quirós, J. Ramón; Agudo, Antonio; Gonzalez, Carlos; Sanchez, Maria-José; Amiano, Pilar; Huerta, José-Maria; Ardanaz, Eva; Wareham, Nicholas J.; Crowe, Francesca L.; Naska, Androniki; Orfanos, Philippos; Trichopoulou, Antonia; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Verschuren, Monique; Drake, Isabel; Sonestedt, Emily; Braaten, Tonje; Rinaldi, Sabina; Romieu, Isabelle; Slimani, Nadia; Norat, Teresa; Riboli, Eilo; Peeters, Petra H.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The evidence that individual dietary and lifestyle factors influence a person’s weight and waist circumference is well established; however their combined impact is less well documented. Therefore, we investigated the combined effect of physical activity, nutrition and smoking status on prospective gain in body weight and waist circumference. We used data of the prospective EPIC-PANACEA study. ...

    • Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort 

      Lu, Yunxia; Cross, Amanda J; Murphy, Neil; Freisling, Heinz; Travis, Ruth C; Ferrari, Pietro; Katzke, Verena A; Kaaks, Rudolf; Olsson, Åsa; Johansson, Ingegerd; Renström, Frida; Panico, Salvatore; Pala, Valeria; Palli, Domenico; Tumino, Rosario; Peeters, Petra H; Siersema, Peter D; Bueno-De-Mesquita, HB; Trichopoulou, Antonia; Klinaki, Eleni; Tsironis, Christos; Agudo, Antonio; Navarro, Camen; Sanchez, Maria-Jose; Barricarte, Aurelio; Boutron-Ruault, Marie-Christine; Fagherazzi, Guy; Racine, Antoine; Weiderpass, Elisabete; Gunter, Marc J; Riboli, Eilo (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-13)
      Background: The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. <p>Methods: We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective ...

    • Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: A systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies 

      Smith, Todd; Muller, David C.; Moons, Karel G.M.; Cross, Amanda J.; Johansson, Mattias; Ferrari, Pietro; Fagherazzi, Guy; Peeters, Petra H. M.; Severi, Gianluca; Hüsing, Anika; Kaaks, Rudolf; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Bonet, Catalina; Rodríguez-Barranco, Miguel; Huerta, Jose Maria; Gurrea, Aurelio Barricarte; Bradbury, Kathryn Erica; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Vineis, Paolo; Bueno-De-Mesquita, Bas; Ohlsson, Bodil; Harlid, Sophia; Van Guelpen, Bethany; Skeie, Guri; Weiderpass, Elisabete; Jenab, Mazda; Murphy, Neil; Riboli, Eilo; Gunter, Marc J.; Aleksandrova, Krasimira Jekova; Tzoulaki, Ioanna (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-03)
      <i>Objective</i> - To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts.<p><p> <i>Design</i> - Models were identified through an update of a published systematic review and validated in the European Prospective Investigation into Cancer and Nutrition (EPIC) and the UK ...

    • A comprehensive analysis of the androgen receptor gene and risk of breast cancer. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) 

      Cox, David G.; Lund, Eiliv; Blanché, Hélène; Pearce, Celeste L.; Calle, Eugenia E.; Colditz, Graham A.; Pike, Malcolm C.; Albanes, Demetrius; Allen, Naomi E.; Amiano, Pilar; Berglund, Göran; Boeing, Heiner; Buring, Julie; Burtt, Noel; Canzian, Federico; Chanock, Stephen; Flavel-Chapelon, Françoise; Feigelson, Heather Spencer; Freedman, Matthew; Haiman, Christopher A.; Hankinson, Susan E.; Henderson, Brian E.; Hoover, Robert; Hunter, David J.; Kaaks, Rudolf; Kolonel, Laurence; Kraft, Peter; LeMarchand, Loic; Palli, Domenico; Peeters, Petra H.M.; Riboli, Elio; Stram, Daniel O.; Thun, Michael; Tjönneland, Anne; Trichopoulos, Dimitrios; Yeager, Meredith (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-09-20)
      Introduction Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer ...

    • Consumption of dairy products and colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC) 

      Murphy, Neil; Norat, Teresa; Ferrari, Pietro; Jenab, Mazda; Bueno-de-Mesquita, Bas; Skeie, Guri; Olsen, Anja; Tjønneland, Anne; Dahm, Christina C.; Overvad, Kim; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Nailler, Laura; Kaaks, Rudolf; Teucher, Birgit; Boeing, Heiner; Bergmann, Manuela M.; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Peeters, Petra H.M.; Dik, Vincent K.; Weiderpass, Elisabete; Lund, Eiliv; Garcia, José Ramon Quiros; Zamora-Ros, Raul; Pérez, Maria José Sánches; Dorronsoro, Miren; Navarro, Carmen; Ardanaz, Eva; Manjer, Jonas; Almquist, Martin; Johansson, Ingegerd; Palmqvist, Richard; Khaw, Kay-Tee; Wareham, Nick; Key, Timothy J.; Crowe, Francesca L.; Fedirko, Veronika; Gunter, Mark J.; Riboli, Elio (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), ...

    • Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort 

      Fortner, Renée T.; Vitonis, Allison F.; Schock, Helena; Hüsing, Anika; Johnson, Theron; Fichorova, Raina Nakove; Fashemi, Titilayo; Yamamoto, Hidemi S.; Tjønneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; La Vecchia, Carlo; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giuseppe; Mattiello, Amalia; Onland-Moret, N. Charlotte; Peeters, Petra H.; Weiderpass, Elisabete; Gram, Inger Torhild; Jareid, Mie; Quirós, José Ramón; Duell, Eric J.; Sánchez, Mariá-José; Chirlaque, María-Dolores; Ardanaz, Eva; Larrañaga, Nerea; Nodin, Björn; Brändstedt, Jenny; Idahl, Annika; Khaw, Kay-Tee; Allen, Naomi; Gunter, Marc; Johansson, Mattias; Dossus, Laure; Merritt, Melissa A.; Riboli, Elio; Cramer, Daniel W.; Kaaks, Rudolf; Terry, Kathryn L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
      Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. <br>Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls ( n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition ...

    • Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score 

      Aleksandrova, Krasimira; Reichmann, Robin; Kaaks, Rudolf; Jenab, Mazda; Bueno-de-Mesquita, Hendrik Bastiaan; Dahm, Christina C.; Eriksen, Anne Kirstine; Tjønneland, Anne; Artaud, Fanny; Boutron-Ruault, Marie-Christine; Hüsing, Anika; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Panico, Salvatore; Grioni, Sara; Sacerdote, Carlotta; Tumino, Rosario; Elias, Sjoerd G.; May, Anne M.; Sandanger, Torkjel M; Skeie, Guri; Sánchez, Maria-Jose; Huerta, José María; Sala, Núria; Gurrea, Aurelio Barricarte; Amiano, Pilar; Drake, Isabel; van Guelpen, Bethany; Key, Tim; Weiderpass, Elisabete; Aglago, Elom K.; Cross, Amanda J.; Tsilidis, Konstantinos K.; Riboli, Elio; Gunter, Marc J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-04)
      <b>Background</b> Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral ...