Browsing Det helsevitenskapelige fakultet by Title

Now showing items 6567-6586 of 10096

    • O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes 

      Barkovskaya, Anna; Seip, Kotryna; Hilmarsdòttir, Bylgja; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Itkonen, Harri (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-05)
      Post-translational modifcation of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the enzyme that catalyzes O-GlcNAcylation – O-GlcNAc-transferase (OGT), and the extent of protein O-GlcNAcylation, are upregulated in tumor tissue, and correlate with cancer progression. ...

    • Obduksjoner. Er de nødvendige som kvalitetskontroll ved et moderne universitetssykehus? 

      Clausen, Vegard H. (Master thesis; Mastergradsoppgave, 2003-09-04)

    • Obesity and obesity-associated cardiometabolic risk factors in indigenous Nenets women from the rural Nenets Autonomous Area and Russian women from Arkhangelsk city 

      Petrenya, Natalia; Brustad, Magritt; Dobrodeeva, Lilya; Bichkaeva, Fatima; Lutfalieva, Gulnara; Cooper, Marie; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Obesity and Staphylococcus aureus Nasal Colonization among Women and Men in a General Population 

      Olsen, Karina; Danielsen, Kjersti; Wilsgaard, Tom; Sangvik, Maria; Sollid, Johanna U. Ericson; Thune, Inger; Eggen, Anne Elise; Simonsen, Gunnar Skov; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Obesity and diabetes mellitus (DM) have been linked to increased risk of infections, and Staphylococcus aureus nasal colonization is a major risk factor for developing infections with the microbe. We therefore sought to find whether body mass index (BMI) and waist circumference (WC) could be associated with S. aureus colonization independent of DM. Methodology: S. aureus colonization ...

    • Obesity at age 20 and the risk of miscarriages, irregular periods and reported problems of becoming pregnant: the Adventist Health Study-2. 

      Jacobsen, Bjarne Koster; Knutsen, Synnøve Fønnebø; Oda, Keiji; Fraser, Gary E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      In a group of 46,000 North-American Adventist women aged 40 and above, we investigated the relationships between body mass index (BMI, kg/m2) at age 20 and the proportion of women who reported at least one miscarriage, periods with irregular menstruation or failing to become pregnant even if trying for more than one straight year. Approximately 31, 14 and 17 %, respectively, reported the three ...

    • Obesity does not protect from subarachnoid haemorrhage: Pooled analysis of 3 large prospective Nordic cohorts 

      Rautalin, Ilari; Kaprio, Jaakko; Ingebrigtsen, Tor; Jousilahti, Pekka; Løchen, Maja-Lisa; Romundstad, Pål Richard; Salomaa, Veikko; Vik, Anne; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Sandvei, Marie Søfteland; Korja, Miikka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
      Background and purpose: Several population-based cohort studies have related higher body mass index (BMI) to a decreased risk of subarachnoid hemorrhage (SAH). The main objective of our study was to investigate whether the previously reported inverse association can be explained by modifying effects of the most important risk factors of SAH—smoking and hypertension.<p> <p>Methods: We conducted ...

    • The obesity epidemic; population levels of visceral adipose tissue and trends in body composition. Insights from The Tromsø Study 

      Lundblad, Marie Wasmuth (Doctoral thesis; Doktorgradsavhandling, 2021-12-09)
      <p><i>Background:</i> Simultaneously with the growing obesity epidemic, cardiometabolic risk have decreased in high-income countries. Do the most frequently used general and abdominal obesity measures (BMI and waist circumference) fail to represent actual obesity and obesity-related health risk? <p><i>Aims:</i> 1) present reference- and threshold values for DXA-derived visceral adipose tissue (VAT) ...

    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-07)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to ...

    • Obesity measures and risk of venous thromboembolism and myocardial infarction 

      Horvei, Lars Daae; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Obesity measures, metabolic health and their association with 15-year all-cause and cardiovascular mortality in the SAMINOR 1 Survey: a population-based cohort study 

      Michalsen, Vilde Lehne; Wild, Sarah H.; Kvaløy, Kirsti; Svartberg, Johan; Melhus, Marita; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-21)
      Background - The mortality of metabolic-obesity phenotypes has been thoroughly studied, but it is not known if or how the association between mortality and body mass index (BMI), waist circumference or a body shape index (ABSI) differ in strata of cardiometabolic health status.<p> <p>Methods - We linked data on 12,815 men and women aged 36–79 years from the SAMINOR 1 Survey with mortality data ...

    • Obesity, body height and risk of venous thromboembolism 

      Horvei, Lars Daae (Doctoral thesis; Doktorgradsavhandling, 2018-01-18)
      Venous thromboembolism (VTE) is a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE). Obesity, as well as a tall stature, are well-known and substantial risk factors for VTE, but the underlying mechanisms behind these associations are not fully understood. The aims of this thesis were to investigate how different patterns of body fat distribution, levels of obesity-related ...

    • Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population 

      Stefansson, Vidar Tor Nyborg (Doctoral thesis; Doktorgradsavhandling, 2019-06-11)
      Obesity is a well-known risk factor for several severe diseases, including diabetes and cardiovascular disease. The metabolic syndrome is a concept related to obesity which includes additional risk factors for disease: increased waist circumference, high blood pressure, elevated fasting glucose, elevated triglycerides and lowered high-density lipoprotein cholesterol levels. Both obesity and the ...

    • Obesity-related cardiovascular risk factors after weight loss : a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention 

      Hofsø, Dag; Nordstrand, Njord; Johnson, Line Kristin; Karlsen, Tor-Ivar; Hager, Helle; Jenssen, Trond Geir; Bollerslev, Jens; Godang, Kristin; Sandbu, Rune; Røislien, Jo; Hjelmesæth, Jøran (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Objective: Weight reduction improves several obesity-related health conditions. We aimed to compare the effect of bariatric surgery and comprehensive lifestyle intervention on type 2 diabetes and obesityrelated cardiovascular risk factors. Design: One-year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104). Methods: Morbidly obese subjects (19–66 years, mean (S.D.) body mass ...

    • Obesity-related venous thromboembolism 

      Frischmuth, Tobias (Doctoral thesis; Doktorgradsavhandling, 2023-02-22)
      Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and multicausal disease. Obesity is a major and likely causal risk factor for VTE. However, to what extent obesity contributes to VTE risk in the general population and the mechanism of obesity-related VTE remain poorly understood. The overall aim of this thesis was (i) to ...

    • Object tracking for improved telementoring and telestration 

      Fatiev, Dmitry (Master thesis; Mastergradsoppgave, 2015-05-15)
      Telementoring in image-guided surgery has long since become a worldwide trend, facilitating faster and better surgical expertise distribution, increased quality of learning for beginner surgeons and better clinical outcomes for patients who no longer have to wait for an expert to travel (or do not have to travel themselves). Since the early days of telementoring, telestration (freehand annotation) ...

    • Objective Versus Subjective Effort in Schizophrenia 

      Kreis, Isabel Viola; Moritz, Steffen; Pfuhl, Gerit (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-09)
      <i>Background and Objectives</i>: Performance on cognitive tasks is often impaired in individuals with schizophrenia (SCZ), possibly resulting from either cognitive deficits (e.g., limited working memory capacity) or diminished mental effort or both. Investment of mental effort itself can be affected by cognitive resources, task load, and motivational factors and has thus proven difficult to measure. ...

    • An observational study of compliance with the Scandinavian guidelines for management of minimal, mild and moderate head injury. 

      Heskestad, Ben Ottar; Waterloo, Knut; Ingebrigtsen, Tor; Romner, Bertil; Harr, Marianne Efskind; Helseth, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The Scandinavian guidelines for management of minimal, mild and moderate head injuries were developed to provide safe and cost effective assessment of head injured patients. In a previous study conducted one year after publication and implementation of the guidelines (2003), we showed low compliance, involving over-triage with computed tomography (CT) and hospital admissions. The aim of the present ...

    • An observational study of sleep characteristics in elite endurance athletes during an altitude training camp at 1800 m 

      Hrozanova, Maria; Kjøsen Talsnes, Rune; Karlsson, Øyvind; McGawley, Kerry; Moen, Frode (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-09)
      Objectives - To observe changes in sleep from baseline and during an altitude training camp in elite endurance athletes.<p> <p>Design - Prospective, observational.<p> <p>Setting - Baseline monitoring at <500 m for 2 weeks and altitude monitoring at 1800 m for 17-22 days.<p> <p>Participants - Thirty-three senior national-team endurance athletes (mean age 25.8 ± S.D. 2.8 years, 16 ...

    • Observed communication skills: how do they relate to the consultation content? A nation-wide study of graduate medical students seeing a standardized patient for a first-time consultation in a general practice setting 

      Anvik, Tor; Nordøy, Tone; Gude, Tore; Vaglum, Per; Bærheim, Anders; Eide, Hilde; Fasmer, Ole B.; Gravgaard, Peter; Grimstad, Hilde; Hjortdahl, Per; Holen, Are; Skirbekk, Helge; Finset, Arnstein (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-11-08)
      Background: In this study, we wanted to investigate the relationship between background variables, communication skills, and the bio-psychosocial content of a medical consultation in a general practice setting with a standardized patient. Methods: Final-year medical school students (N = 111) carried out a consultation with an actor playing the role of a patient with a specific somatic complaint, ...

    • Observer agreement of imaging measurements used for evaluation of dentofacial deformity in juvenile idiopathic arthritis 

      Fischer, Johannes Maria; Halbig, Josefine Mareile; Augdal, Thomas Angell; Angenete, Oskar W; Stoustrup, Peter; Kristensen, Kasper Dahl; Skeie, Marit Slåttelid; Tylleskär, Karin; Rosén, Annika; Shi, Xie-Qi; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-02)
      Objectives: To examine the precision of imaging measures commonly used to assess mandibular morphology in children and adolescents with juvenile idiopathic arthritis (JIA). Secondly, to compare cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in the measurement of condylar height.<p> <p>Methods: Those included were children diagnosed with JIA during 2015–18 who had had ...