Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity have limited their role as prognostic markers and therapeutic targets. <p><p>Methods: To identify markers associated with myeloid cells in metastatic tumours, we compared transcriptomic ...

Background:<br> Recent research demonstrates that for many indigenous Sami people, experiencing ethnic discrimination is a regular occurrence. The present study was designed to provide estimates of the prevalence of self-reported discrimination in order to identify specific settings where discrimination happened, to identify perpetrators and to examine individuals’ responses to the discrimination. ...

Objective: To investigate external-cause mortality among 21 609 Norwegian male military peacekeepers deployed to Lebanon during 1978–1998. <br>Methods: The cohort was followed from first day of deployment through 2013, and mortality during deployment and post discharge was assessed using standardized mortality ratios (SMR) calculated from national rates in Norway. Poisson regression was used ...

The genetic repertoire underlying teleost immunity has been shown to be highly variable. A rare example is Atlantic cod and its relatives Gadiformes that lacks a hallmark of vertebrate immunity: Major Histocompatibility Complex class II. No immunological studies so far have fully unraveled the functionality of this particular immune system. Through global transcriptomic profiling, we investigate the ...

Barns rett til å høres blir stadig formelt styrket. Meklere i familievernet som skal iverksette denne retten i forbindelse med foreldres samlivsbrudd, har et betydelig rom for skjønnsutøvelse. Det foreligger begrenset kunnskap om hvordan og hvorfor praksis varierer. I denne artikkelen analyserer vi 20 mekleres diskusjoner rundt barns rett til å høres i forbindelse med foreldremekling. Vi anlegger ...

This paper describes the extent and variation in health disparities between Indigenous and non-Indigenous people within Alaska, Greenland and the northern regions of Canada, Russia and the Nordic countries. We accessed official health statistics and reviewed research studies. We selected a few indicators of health status, health determinants and health care to demonstrate the health disparities that ...

<p><i>Objective:</i> This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. <p><i>Methods:</i> The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and ...

In their lead article, Klug et al. conceptualize job insecurity as a multilevel construct whereby individuals are situated in meso- and macro-level contexts. Their resulting model highlights that the experience of job insecurity, as well as reactions to job insecurity, are not only affected by factors emanating from individuals' direct environment (i.e., at the individual level) but also from different ...

Background: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identify adjuvant insufficiently treated patients to be offered secondary adjuvant treatment intervention, and as a surrogate marker for therapy response.<p> <p>Methods: A total of ...

An outbreak of hospital-acquired Acinetobacter baumannii infections, caused by a blaOXA-23-positive carbapenem-resistant strain belonging to international clone II/ST2, was detected in Latvia. The strain was partially equipped with the armA gene and the intI1-aacA4-catB8-aadA1-qacE 1 class 1 integron. In addition, the strain carried AbaR25, a novel AbaR4-like resistance island of 46,500 bp ...