The aim of this study was to examine the burden of fungal disease in Norway, contributing to a worldwide effort to improve awareness of the needs for better diagnosis and treatment of such infections. We used national registers and actual data from the Departments of Microbiology from 2015 and estimated the incidence and/or prevalence of superficial, allergic and invasive fungal disease using published ...

<b>Background</b><br> The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway. <br><b>Methods</b><br> Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ...

Background: Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine perform similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFRrelated traits associated with cystatin C and creatinine levels. We investigated non-GFRrelated associations between eGFR and two types ...

Incidence of venous thromboembolism (VTE) risk varies by age and sex. Some studies have reported overall higher risk in men, especially when VTEs triggered by female reproductive factors are excluded. However, higher mortality rates in men may have led to overestimation of lifetime VTE risk in men compared with women. Therefore, we estimated the lifetime risk of VTE in men and women in a Danish, ...

While most early childhood education and care (ECEC) programs taken to scale in the United States have served socially disadvantaged 3- to 5-years-olds, Norway scaled up universal ECEC from age 1. We investigated the consequences of Norway’s universal ECEC scale-up for children’s early language skills, exploiting variation in ECEC coverage across birth cohorts and municipalities in a population-based ...

Treatment of infectious diseases is often long and requires patients to take drugs even after they have seemingly recovered. This is because of a phenomenon called persistence, which allows small fractions of the bacterial population to survive treatment despite being genetically susceptible. The surviving subpopulation is often below detection limit and therefore is empirically inaccessible but can ...

Androgens are considered important in normal prostate physiology and prostate cancer (PCa) pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking. This indicates additional mediators contributing to cancer development. We sought to determine the prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue microarrays ...

Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ERβ RNAs (or containing luciferase control) encoded within an adeno-associated viral vector, we silenced these receptors in the ventromedial nucleus of the ...

Forskning viser at det fysiske miljøet er en nøkkeldeterminant for barns fysiske aktivitetsnivå. I Rammeplan for barnehagens innhold og oppgaver står det: Barnehagen skal ha areal og utstyr nok, tilby gode oppvekstmiljø som er både trygge og utfordrende og som skal fremme læring og mestring (KD 2006). I denne artikkelen presenteres resultater fra en landsrepresentativ kvantitativ spørreundersøkelse ...

I denne oppgaven ble kreftceller fra livmorhals bestrålt med gammastråler. Strålingens effekt på celletetthet, celledød og cellesyklus ble undersøkt for å si noe om disse cellenes strålesensitivitet. Den ekstracellulære konsentrasjonen av cGMP ble også målt. Dette sykliske nukleotidet har relevans fordi det har vist seg at nivået av cGMP går ned etter behandling hos pasienter med livmorhalskreft.