Browsing Det helsevitenskapelige fakultet by Title

Now showing items 3768-3787 of 10152

    • Genetic variability in the sdrD gene in Staphylococcus aureus from healthy nasal carriers 

      Ajayi, Clement; Åberg, Espen; Askarian, Fatemeh; Sollid, Johanna U Ericson; Johannessen, Mona; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-16)
      <p><i>Background</i>: <i>Staphylococcus aureus</i> cell wall anchored Serine Aspartate repeat containing protein D (<i>sdrD</i>) is a member of the microbial surface component recognising adhesive matrix molecules (MSCRAMMs). It is involved in the bacterial adhesion and virulence. However the extent of genetic variation in <i>S. aureus sdrD</i> gene within isolates from healthy carriers are not ...

    • Genetic variation in P2RX7 and pain tolerance 

      Kambur, Oleg; Kaunisto, Mari A; Winsvold, Bendik K S; Wilsgaard, Tom; Stubhaug, Audun; Zwart, John-Anker; Kalso, Eija; Nielsen, Christopher Sivert (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-20)
      P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through ...

    • Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies 

      Nimptsch, Katharina; Song, Mingyang; Aleksandrova, Krasimira; Katsoulis, Michail; Freisling, Heinz; Jenab, Mazda; Gunter, Marc J.; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Bueno-De-Mesquita, Hendrik Bastiaan; Chong, Dawn Q.; Jensen, Majken K.; Wu, Chunsen; Overvad, Kim; Kühn, Tilman; Barrdahl, Myrto; Melander, Olle; Jirström, Karin; Peeters, Petra H.; Sieri, Sabina; Panico, Salvatore; Cross, Amanda J.; Riboli, Elio; van Guelpen, Bethany; Myte, Robin; Huerta, José María; Rodriguez-Barranco, Miguel; Quirós, José Ramón; Dorronsoro, Miren; Tjønneland, Anne; Olsen, Anja; Travis, Ruth; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Severi, Gianluca; Bonet, Catalina; Palli, Domenico; Janke, Jürgen; Lee, Young-Ae; Boeing, Heiner; Giovannucci, Edward L.; Ogino, Shuji; Fuchs, Charles S.; Rimm, Eric; Wu, Kana; Chan, Andrew T.; Pischon, Tobias (Journal article; Manuskript; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-05-26)
      Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 ...

    • Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
      Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE) events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ...

    • Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study 

      Zostautiene, Leva; Jorde, Rolf; Schirmer, Henrik; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Kamycheva, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
      Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...

    • Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization 

      Dam, Veerle; Onland-Moret, N. Charlotte; Burgess, Stephen; Chirlaque, Maria Dolores; Peters, Sanne A.E.; Schuit, Ewoud; Tikk, Kaja; Weiderpass, Elisabete; Oliver-Williams, Clare; Wood, Angela M.; Tjønneland, Anne; Dahm, Christina C; Overvad, Kim; Boutron-Rualt, Marie-Christine; Schulze, Matthias B.; Trichopoulou, Antonia; Ferrari, Pietro; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Matullo, Giuseppe; Panico, Salvatore; Boer, Jolanda M. A.; Verschuren, W.M. Monique; Waaseth, Marit; Pérez, María José Sánchez; Amiano, Pilar; Imaz, Liher; Moreno-Iribas, Conchi; Melander, Olle; Harlid, Sophia; Nordendahl, Maria; Wennberg, Patrik; Key, Timothy J.; Riboli, Elio; Santiuste, Carmen; Kaaks, Rudolf; Katzke, Verena; Langenberg, Claudia; Wareham, Nicholas J.; Schunkert, Heribert; Erdmann, Jeanette; Willenborg, Christina; Hengstenberg, Christian; Kleber, Marcus E.; Delgado, Graciela; März, Winfried; Kanoni, Stavroula; Dedoussis, George; Deloukas, Panos; Nikpay, Majid; McPherson, Ruth; Scholz, Markus; Teren, Andrej; Butterworth, Adam S.; van der Schouw, Yvonne T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-20)
      Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.<p> <p>Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD ...

    • Genetically predicted cortisol levels and risk of venous thromboembolism 

      Allarai, Elias; Lee, Wei-Hsuan; Burgess, Stephen; Larsson, Susanna C.; Lindstrom, Sara; Wang, Lu; Smith, Erin N.; Gordon, William; Van Hylckama Vlieg, Astrid; De Andrade, Mariza; Brody, Jennifer A.; Pattee, Jack W.; Haessler, Jeffrey; Brumpton, Ben Michael; Chasman, Daniel I.; Suchon, Pierre; Chen, Ming-Huei; Turman, Constance; Germain, Marine; Wiggins, Kerri L.; Macdonald, James; Brækkan, Sigrid Kufaas; Armasu, Sebastian M.; Pankratz, Nathan; Jackson, Rabecca D.; Nielsen, Jonas B; Giulianini, Franco; Puurunen, Marja K.; Ibrahim, Manal; Heckbert, Susan R.; Bammler, Theo K.; Frazer, Kelly A.; Mccauley, Bryan M.; Taylor, Kent; Pankow, James S.; Reiner, Alexander P.; Gabrielsen, Maiken Elvestad; Deleuze, Jean-Francois; O'Donnell, Chris J.; Kim, Jihye; Mcknight, Barbara; Kraft, Peter; Hansen, John Bjarne; Rosendaal, Frits Richard; Heit, John A.; Psaty, Bruce M.; Tang, Weihong; Kooperberg, Charles; Hveem, Kristian; Ridker, Paul M.; Morange, Pierre-Emmanuel; Johnson, Andrew D.; Kabrhel, Christopher; Alexandretrégouët, David; Smith, Nicholas L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
      Introduction - In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk ...

    • Genital Chlamydia trachomatis infections among adolescents in a high-incidence area in Norway: genotypes, prevalence, early sexual behaviour and testing patterns – a cross-sectional study The Finnmark High School Study (FHSS) 

      Gravningen, Kirsten Midttun (Doctoral thesis; Doktorgradsavhandling, 2013-12-06)
      Chlamydia trachomatis is the most commonly reported curable sexually transmitted infection in Western high-income countries and can cause severe female reproductive tract morbidity. Despite extensive control efforts, chlamydia rates have increased in most countries since the mid-1990s. Young persons and especially adolescent girls have the highest infection rates. In general, girls are tested far ...

    • The genome sequence of Atlantic cod reveals a unique immune system 

      Star, Bastiaan; Nederbragt, Alexander Johan; Jentoft, Sissel; Grimholt, Unni; Malmstrøm, Martin; Gregers, Tone Fredsvik; Rounge, Trine Ballestad; Paulsen, Jonas; Solbakken, Monica Hongrø; Sharma, Animesh; Wetten, Ola Frang; Lanzén, Anders; Winer, Roger; Knight, James; Vogel, Jan-Hinnerk; Aken, Bronwen; Andersen, Øivind; Lagesen, Karin; Tooming-Klunderud, Ave; Edvardsen, Rolf; Kirubakaran, G. Tina; Espelund, Mari; Nepal, Chirag; Previti, A. Christopher; Karlsen, Bård Ove; Moum, Truls; Skage, Morten; Berg, Paul Ragnar; Gjøen, Tor; Kuhl, Heiner; Thorsen, Jim; Malde, Ketil; Reinhardt, Richard; Du, Lei; Johansen, Steinar Daae; Searle, Steve; Lien, Sigbjørn; Nilsen, Frank; Jonassen, Inge; Omholt, Stig W; Stenseth, Nils Christian; Jakobsen, Kjetill Sigurd (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-08-10)
      Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture1, 2. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 ...

    • The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay 

      Hjerde, Erik; Holden, Matthew TG; Seeger, Kathy; Lorentzen, Marit Sjo; Bason, Nathalie; Paulsen, Steinar; Willassen, Nils Peder; Churcher, Carol; Harris, David; Norbertczak, Halina; Quail, Michael A; Sanders, Suzanne; Thurston, Scott; Parkhill, Julian; Thomson, Nicholas R (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-19)
      <b>Background:</b> The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo.<BR><BR> <b>Results:</b> In total, 4 286 protein coding sequences were identified, and the 4.6 Mb genome of A. salmonicida has a six partite architecture with two chromosomes and four ...

    • A genome-wide "pleiotropy scan" does not identify new susceptibility Loci for estrogen receptor negative breast cancer 

      Campa, D; Barrdahl, M; Tsilidis, KK; Severi, G; Diver, WR; Siddiq, A; Chanock, S; Hoover, RN; Ziegler, RG; Berg, CD; Buys, SS; Haiman, CA; Henderson, BE; Schumacher, FR; Le Marchand, L; Flesch-Janys, D; Lindstrom, S; Hunter, DJ; Hankinson, SE; Willett, WC; Kraft, P; Cox, DG; Khaw, KT; Tjønneland, A; Dossus, L; Trichopoulos, D; Panico, S; Van Gils, CH; Weiderpass, Elisabete; Barricarte, A; Sund, M; Gaudet, MM; Giles, G; Southey, M; Baglietto, L; Chang-Claude, J; Kaaks, R; Canzian, F (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Genome-wide analysis of DNA methylation and gene Expression patterns in purified, uncultures human liver cells and activated hepatic stellate cells 

      Taghdouini, Adil El; Sørensen, Anita Løvstad; Reiner, Andrew Henry; Coll, Mar; Verhulst, Stefaan; Mannaerts, Inge; Øie, Cristina Ionica; Smedsrød, Bård; Najimi, Mustapha; Sokal, Etienne; Luttun, Aernout; Sancho-Bru, Pau; Collas, Philippe; Grunsven, Leo A van (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-31)
      <p>Background & Aims: Liver fibrogenesis – scarring of the liver that can lead to cirrhosis and liver cancer – is characterized by hepatocyte impairment, capillarization of liver sinusoidal endothelial cells (LSECs) and hepatic stellate cell (HSC) activation. To date, the molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. Here, we assess the transcriptome ...

    • Genome-wide association study identifies multiple risk loci for renal cell carcinoma 

      Scelo, Ghislaine; Purdue, Mark P.; Brown, Kevin M.; Johansson, Mattias; Wang, Zhaoming; Eckel-Passow, Jeanette E.; Ye, Yuanqing; Hofmann, Jonathan N.; Choi, Jiyeon; Foll, Matthieu; Gaborieau, Valerie; Machiela, Mitchell J.; Colli, Leandro M.; Li, Peng; Sampson, Joshua N.; Abedi-Ardekani, Behnoush; Besse, Celine; Blanche, Helene; Boland, Anne; Burdette, Laurie; Chabrier, Amelie; Durand, Geoffroy; Le Calvez-Kelm, Florence; Prokhortchouk, Egor; Robinot, Nivonirina; Skryabin, Konstantin G.; Wozniak, Magdalena B.; Yeager, Meredith; Basta-Jovanovic, Gordana; Dzamic, Zoran; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Szeszenia-Dabrowska, Neonila; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Baglietto, Laura; Boeing, Heiner; Khaw, Kay-Tee; Weiderpass, Elisabete; Ljungberg, Börje; Sitaram, Raviprakash T.; Bruinsma, Fiona; Jordan, Susan J.; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars Johan; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C.; Wolk, Alicja; Banks, Rosamonde E.; Selby, Peter J.; Easton, Douglas F.; Pharoah, Paul; Andreotti, Gabriella; Freeman, Laura E Beane; Koutros, Stella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E.; Edwards, Todd L.; Lipworth, Loren; Gapstur, Susan M.; Stevens, Victoria L.; Carol, Hallie; Freedman, Matthew L.; Pomerantz, Mark M.; Cho, Eunyoung; Kraft, Peter; Preston, Mark A.; Wilson, Kathryn M.; Gaziano, J. Michael; Sesso, Howard D.; Black, Amanda; Freedman, Neal D.; Huang, Wen-Yi; Anema, John G.; Kahnoski, Richard J.; Lane, Brian R.; Noyes, Sabrina L.; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L.; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E.; Wood, Christopher; Eisen, Timothy; Henrion, Marc; Larkin, James; Barman, Poulami; Leibovich, Bradley C.; Choueiri, Toni K.; Lathrop, G. Mark; Rothman, Nathaniel; Deleuze, Jean-Francois; McKay, James D.; Parker, Alexander S.; Wu, Xifeng; Houlston, Richard S.; Brennan, Paul; Chanock, Stephen J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-09)
      Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk ...

    • A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium 

      McKay, James D.; Truong, Therese; Gaborieau, V; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, G; Zaridze, D; Shangina, O; Szeszenia-Dabrowska, N; Lissowska, Jolanta; Rudnai, P; Fabianova, E; Bucur, A; Bencko, V; Holcatova, I; Janout, V; Foretova, L; Lagiou, Pagona; Trichopoulos, Dimitrios; Benhamou, S; Ahrens, Wolfgang; Bouchardy, C; Merletti, F; Richiardi, L; Talamini, R; Simonato, L; Barzan, L; Kjærheim, Kristina; Macfarlane, G; Agudo, Antonio; Macfarlane, Tatiana V.; Canova, C; Castellsague, X; Conway, DI; Lowry, R; Healy, CM; McKinney, PA; Toner, ME; Znaor, A; Menezes, A; Curado, MP; Koifman, S; Neto, JE; Wünsch-Filho, V; Boccia, S; Arzani, D; Garrote, LF; Cadoni, G; Olshan, AF; Weissler, MC; Luo, JC; Funkhouser, WK; Lubinski, Jan; Lener, M; Trubicka, J; Schwartz, SM; Oszutowska, D; Doody, DR; Chen, C; Fish, S; Lazarus, P; Muscat, JE; Gallagher, CJ; Zhang, Zuo-Feng; Chang, SC; Wei, QY; Sturgis, EM; Franceschi, S; Kelsey, KT; Wang, LE; Herrero, R; Marsit, CJ; McClean, MD; Romkes, M; Nelson, HH; Buch, S; Nukui, T; Zhong, SL; Lacko, M; Manni, JJ; McLaughlin, J; Hung, RJ; Peters, WHM; Vatten, Lars Johan; Njølstad, Inger; Goodman, GE; Field, JK; Palli, D; Liloglou, T; Clavel-Chapelon, F; Vineis, P; Krogh, V; Tumino, R; Panico, S; Martinez, Carmen; Gonzalez, CA; Quiros, JR; Navarro, C; Larranaga, N; Khaw, KT; Ardanaz, E; Key, T; Peeters, PHM; Bueno-De-Mesquita, H. Bas; Boeing, H; Overvad, K; Trichopoulou, A; Linseisen, J; Hallmans, G; Tjønneland, Anne; Riboli, Elio; Kumle, Merethe; Valk, K; Voodern, Tonu; Metspalu, Andres; Boland, A; Zelenika, D; Delepine, M; Foglio, M; Lechner, D; Blanché, Hélène; Gut, Ivo G.; Galan, P; Hashibe, Mia; Heath, Simon; Hayes, Richard B.; Lathrop, Mark; Boffetta, Paolo; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and ...

    • Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth 

      Helgeland, Øyvind; Vaudel, Marc; Juliusson, Petur Benedikt; Holmen, Oddgeir Lingaas; Juodakis, Julius; Bacelis, Jonas; Jacobsson, Bo; Lindekleiv, Haakon; Hveem, Kristian; Lie, Rolv T.; Knudsen, Gun Peggy Strømstad; Stoltenberg, Camilla; Magnus, Per; Sagen, Jørn V.; Molven, Anders; Johansson, Stefan; Njølstad, Pål Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-01)
      Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 measurements) in the Norwegian Mother, Father, and Child Cohort Study, replicated in 5235 children, we identify a transient effect in the leptin receptor (<i>LEPR</i>) locus: no effect ...

    • Genome-wide DNA methylation in saliva and body size of adolescent girls 

      Rounge, Trine Ballestad; Page, Christian; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina K; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-20)
      Aim:<br>We performed an epigenome-wide association study within the Finnish Health in Teens cohort to identify differential DNA methylation and its association with BMI in adolescents.<br>Materials & methods:<br>Differential DNA methylation analyses of 3.1 million CpG sites were performed in saliva samples from 50 lean and 50 heavy adolescent girls by genome-wide targeted bisulfite-sequencing.<br> ...

    • Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-22)
      <p><i>Background and Aims</i>: The aim of this study was to investigate the genome-wide DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the relationship between DNA methylation patterns and gene expression levels in tissue biopsies from a well-stratified treatment-naïve UC patient group.</p> <p><i>Methods</i>; Mucosal biopsies from treatment-naïve patients [n = ...

    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-07)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, ...

    • Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura : The emerging Gene Portrait of the Mesothelioma Phenotype 

      Olsen, Karina Standahl; Røe, Oluf Dimitri; Anderssen, Endre; Helge, Eli; Pettersen, Caroline Hild; Sandeck, H; Haaverstad, Rune; Lundgren, Steinar; Larsson, Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...