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    • Hypertensjon i distriktshelsetjenesten 

      Kvamme, Jan-Ivar (Research report; Forskningsrapport, 1980)

    • Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis 

      Gundersen, Mona Dixon; Larsen, Kenneth Bowitz; Johnsen, Kay-Martin; Goll, Rasmus; Florholmen, Jon; Haraldsen, Guttorm (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ...

    • Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus 

      Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)
      While it is a common practice to monitor complement levels in patients with systemic lupus erythematosus to aid in flare prediction and detection, it is unclear if this strategy is helpful in preventing subsequent organ damage. We studied longitudinal complement levels in 102 SLE patients during a median follow-up of 13.8 years (IQR 7.0, 23.1). Low complement was defined as C3 < 0.84 g/L and/or ...

    • Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts 

      Fasanelli, Francesca; Baglietto, Laura; Ponzi, Erica; Guida, Florence; Campanella, Gianluca; Johansson, Mattias; Grankvist, Kjell; Johansson, Mikael; Assumma, Manuela Bianca; Naccarati, Alessio; Chadeau-Hyam, Marc; Ala, Ugo; Faltus, Christian; Kaaks, Rudolf; Risch, Angela; De Stavola, Bianca; Hodge, Allison; Giles, Graham G.; Southey, Melissa C.; Relton, Caroline L.; Haycock, Philip C.; Lund, Eiliv; Polidoro, Silvia; Sandanger, Torkjel M; Severi, Gianluca; Vineis, Paolo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-15)
      DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, ...

    • Hyposensibilisering med katteallergenekstrakter : en litteraturstudie. 

      Martinsen, Julia Madeleine (Master thesis; Mastergradsoppgave, 2008-09-15)
      Denne litteraturstudien omhandler spesifikk immunterapi (SIT) med katteallergenekstrakter. Ved SIT (også benevnt ”hyposensibilisering” eller ”allergivaksine”) tilføres pasienten ett eller flere allergen over tid med formål å minske pasientens følsomhet ovenfor aktuelle allergen. SIT administreres subcutant (SCIT) eller sublingualt (SLIT) Felint protein D 1 (Fel d 1)er vanligste årsak til ...

    • Hypotermi og væskebehandling 

      Bjerkaas, Eivind; Iversen, Rolf Arne (Master thesis; Mastergradsoppgave, 2002)

    • Hypothalamic - pituitary stress axis in female patients with bulimia nervosa. Neuroendocrine diurinal regulation of hunger and satiety in women with bulimia nervosa. 

      Drivenes, Elin; Agledahl, Ingvild (Master thesis; Mastergradsoppgave, 2002-11)

    • Hypothalamic clock involvement in cluster headache. A study of chronobiology, sleep, and cranial autonomic function in cluster headache 

      Ofte, Hilde Karen (Doctoral thesis; Doktorgradsavhandling, 2016-10-24)
      Cluster headache has been claimed to be a chronobiological disorder because of its striking periodic occurrence. This suggests that the biological clock is involved in the pathophysiology of the disease, but few researchers have studied this in depth. In this thesis, we have studied several aspects of chronobiology in cluster headache patients. First, we assessed the periodicity of headache attacks, ...

    • Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ...

    • Hypothermia-induced myocardial calcium overload –a study of intracellular Ca2+ handling during profound hypothermia and rewarming 

      Wold, Ragnhild Margrete (Doctoral thesis; Doktorgradsavhandling, 2016-09-30)
      We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ...

    • Hypothermic cardiac arrest far away from the center providing rewarming with extracorporeal circulation. 

      Mark, Eckhard; Jacobsen, Olaf; Kjerstad, Astrid Kristine; Næsheim, Torvind; Busund, Rolf; Bahar, Ramez; Jensen, Jon Kjetil; Skorpen, Per Kristian; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      A 41-year-old man suffered hypothermic cardiac arrest after water immersion and was transported to our university hospital by ambulance helicopter for rewarming on cardiopulmonary bypass. He resumed spontaneous cardiac activity 6 h 52 min after cardiac arrest and recovered completely.

    • Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study 

      Nilsen, Linn; Sharashova, Ekaterina; Løchen, Maja-Lisa; Danaei, Goodarz; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)
      Aims - To use the parametric g-formula to estimate the long-term risk of atrial fibrillation (AF) by sex and education under hypothetical interventions on six modifiable risk factors.<p> <p>Methods and results - We estimated the risk reduction under hypothetical risk reduction strategies for smoking, physical activity, alcohol intake, body mass index, systolic, and diastolic blood pressure in 14 ...

    • Hypothetical interventions and risk of myocardial infarction in a general population: application of the parametric g-formula in a longitudinal cohort study-the Tromsø Study 

      Wilsgaard, Tom; Vangen-Lønne, Anne Merete; Mathiesen, Ellisiv B; Løchen, Maja-Lisa; Njølstad, Inger; Heiss, Gerardo; Danaei, Goodarz (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-24)
      <i>Objectives</i> - The aim of this study was to use the parametric g-formula to estimate the 19-year risk of myocardial infarction (MI) under hypothetical interventions on six cardiovascular risk factors. <p> <p><i>Design and setting</i> - A populations-based cohort study with repeated measurements, the Tromsø Study. <p> <p><i>Primary outcome measure</i> - Myocardial infarction. <p> <p>< ...

    • The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery 

      Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-16)
      Systemic administration of drugs is ineffective in the treatment of central nervous system disorders because of the blood-brain barrier. Nasal administration has been suggested as an alternative administration route as drugs absorbed in the olfactory epithelium bypass the blood-brain barrier and reach the brain within minutes. However, the nasal mucosa properties (e.g., tonicity, pH) are not constant ...

    • Hypoxia and hypotension in patients intubated by physician staffed helicopter emergency medical services - a prospective observational multi-centre study 

      Sunde, Geir Arne; Sandberg, Mårten; Lyon, Richard; Fredriksen, Knut; Burns, Brian; Hufthammer, Karl Ove; Røislien, Jo; Sóti, Ákos; Jäntti, Helena; Lockey, David; Heltne, Jon-Kenneth; Sollid, Stephen J. M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)
      The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators of care provided by emergency medical services. Excluding cardiac arrests, critical trauma and non-trauma patients remain the two major groups to which helicopter emergency ...

    • Hypoxic markers and prognosis in non-small cell lung cancer (NSCLC) 

      Andersen, Sigve (Doctoral thesis; Doktorgradsavhandling, 2011-11-30)
      Lungekreft er uten sammenligning den kreftsykdommen som tar flest liv i Norge og 6 personer dør i gjennomsnitt hver dag av sykdommen. De som blir oppdaget i et tidlig stadium kan opereres med mål om å bli kurert. Likevel dør nesten halvparten av de som blir operert av lungekreft og behovet for nye behandlingsalternativer er stort. Andersens funn viser at markører for lave surstoff nivåer og ...

    • Hyppighet og alvorlighetsgrad av selvopplevde menstruasjonssymptomer og bivirkninger ved bruk av hormonell prevensjon, sett i sammenheng med fysisk aktivitet i idrett og trening blant norske håndballspillere 

      Gunnarshaug, Tora Vilje Dragland (Master thesis; Mastergradsoppgave, 2023-05-15)
      Bakgrunn: Kvinner er svært underrepresentert når det gjelder idrett og trening i vitenskapelig forskning sammenlignet med menn. En forståelse av symptomer i menstruasjonssyklusen og bivirkninger ved bruk av hormonell prevensjon (HP) kan bidra til å optimalisere prestasjon i idrett og trening blant kvinner. Hensikt: Målet med denne oppgaven var å undersøke (1) hvordan naturlig menstruerende (NM), ...

    • Hysterektomi ved kraftige menstruasjonsblødninger: forenklet metodevurdering 

      Evensen, Line Holtet; Espeland, Anna Lien; Ashtiani, Vida Hamidi; Risstad, Hilde; Elvsaas, Ida-Kristin Ørjasæter (Research report; Forskningsrapport, 2021-06-10)
      Vi har på oppdrag fra Bestillerforum for nye metoder utarbeidet en forenklet metodevurdering om hysterektomi (kirurgisk fjerning av livmor) ved kraftige menstruasjonsblødninger. Dette er en pilot i et prosjekt innen revurdering som ledes av Helse Midt-Norge RHF. Vi har hentet ut resultater for effekt og sikkerhet og vurderinger av tillit til resultatene for effekt fra en rapport av The National ...

    • Høy forekomst av diabetes mellitus type 2 blant urbefolkninger – Hvorfor er det slik? En sammenligning av to urbefolkninger vs majoritetsbefolkning 

      Olsen, Ingelin Christin Evensen (Master thesis; Mastergradsoppgave, 2016-05-26)
      Formål: Diabetes mellitus type II er et økende problem i dagens samfunn. Sykdommen påvirker enkeltpersoner, både i det daglige liv, men også med alvorlige komplikasjoner. Forekomsten er økende på verdensbasis. I den vestlige verden er en stor årsak til dette endring i livsstil, med mindre fysisk aktivitet og endret kosthold. Helseforholdene til samer i dagens Norge er ikke et påtrengende problem ...

    • Høydose metotreksat i behandling av akutt leukemi hos barn og ungdom: en kartlegging av forekomsten av forsinket utskillelse 

      Knudsen, Dina Elisabet (Master thesis; Mastergradsoppgave, 2023-05-31)
      Årlig får 35-40 barn <16 år i Norge diagnosen akutt lymfoblastisk leukemi. Dette er en av de vanligste typene kreft hos barn. Diagnosen stilles i de fleste tilfeller ved analyse av beinmargsaspirat, hvor man ser mange umodne hvite blodceller. Diagnosekriteriumet er at >20% av kjerneførende celler i margen er blaster. Videre er behandlingen tredelt i induksjon, konsolidering og vedlikehold. I ...