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    • Ikke bare elendighet - en kvalitativ studie om hvordan ansatte tilknyttet Statens Barnehus påvirkes av jobben, og hvordan de best kan ivaretas 

      Morken, Marte; Farstad, Tonje Persson (Master thesis; Mastergradsoppgave, 2020-12-11)
      Studiens formål er å undersøke hvordan ansatte tilknyttet Statens Barnehus opplever at arbeidet med traumeutsatte barn og unge påvirker deres mentale helse, samt hvilke faktorer som oppleves som beskyttende mot arbeidets belastninger. Studien inkluderer data fra 11 dybdeintervju med politiavhørere, psykologer og seniorrådgivere tilknyttet ulike Barnehus i Norge. Systematisk tekstkondensering ble ...

    • Ikke gjennomførte oppdrag : hva stanser ambulansehelikopteret, og hva blir alternativet? 

      Elstad, Ann Mari (Master thesis; Mastergradsoppgave, 2008-06)
      Bakgrunn: Der finnes flere viktige årsaker til at ambulansehelikoptertjenesten ikke kan gjennomføre oppdrag. Siden ambulansehelikopteret oftest rekvireres til spesielt syke og skadde pasienter var det av interesse å kartlegget problemets omfang og hvilke alternativer som da ble benyttet. Material og metode: Vi benyttet data over ambulansehelikopteroppdrag rekvirert til basen i Tromsø fra perioden ...

    • Ikke invasiv testing (NIPT) for påvisning av trisomi 21,18 og 13. 

      Juvet, Lene Kristine; Ormstad, Sari Susanna; Schneider, Anna; Solberg, Berge; Arentz-Hansen, Helene; Kvamme, Maria Knoph; Fure, Brynjar (Research report; Forskningsrapport, 2016)
      Trisomi er en form for kromosomavvik som innebærer at et individ har tre kopier av ett kromosom istedenfor to som er det normale. Blant de tre hyppigste typer trisomier en kan fødes med er trisomi 21 (Downs syndrom), trisomi 18 og trisomi 13. Dagens praksis i Norge er at alle gravide over 38 år får tilbud om screening med kombinasjon av tidlig ultralyd og blodprøve (KUB). Der hvor testen viser mul ...

    • Ikke som jeg gjør, men som jeg sier 

      Gjesvik, Kalle (Chronicle; Kronikk, 2013)
      Om "nyere" syntetiske rusmidler - kalt "Legal Highs" - og deres samfunnsmessige betydning. Kort analyse av muligheter samfunnet har til å møte dem, med vekt på primærforebyggende tiltak.

    • Ikke-alkoholisk fettleversykdom (NAFLD) i en generell populasjon og assosiasjon til kardiovaskulær sykdom 

      Bogen, Daniel (Master thesis; Mastergradsoppgave, 2018-06-03)
      Bakgrunn: Ikke-alkoholisk fettleversykdom (NAFLD) er i ferd med å bli den vanligste årsaken til kronisk leversykdom i verden, og er også en av de vanligste årsakene til forhøyede leverenzymer. Tilstanden påvirker ikke kun leveren, men er del av en multisystem-sykdom som påvirker en rekke andre organsystemer i kroppen, inkludert det kardiovaskulære system. En økende mengde forskning tyder på at NAFLD ...

    • Ikke-faglige mediers fremstilling av meslinger og behandlingsalternativer. Er informasjon pålitelig og av god kvalitet? 

      Stavdal, Tine Pettersen (Master thesis; Mastergradsoppgave, 2015-11-30)
      Min masteroppgave studerer om ikke-faglige medier er en pålitelig kilde for informasjon og valg av behandlingsalternativ(er) for meslinger. Det er et interessant tema fordi ny forekomst av meslinger indikerer at vaksinedekningen ikke er tilfredsstillende, på tross av at det eksisterer en effektiv og veldokumentert MMR-vaksine. Fremgangsmåten for å besvare problemstillingen er gjort med utgangspunkt ...

    • Ikke-invasiv prenatal testing (NIPT) for kjønnsbestemmelse av foster. Metodevurdering 

      Ormstad, Sari Susanna; Schneider, Anna; Solberg, Berge; Fure, Brynjar; Juvet, Lene Kristine (Research report; Forskningsrapport, 2016-12)
      X‐bundne recessive sykdommer er alvorlige arvelige sykdommer som hovedsakelig rammer gutter. Når en kvinne som er bærer av en X‐bundet recessiv sykdom føder barn, kan hun få en frisk jente, en frisk jente som er bærer som sin mor, en frisk gutt, eller en gutt som har den X‐bundne recessive sykdommen. Dagens praksis i Norge er at alle gravide kvinner med økt risiko for å få et barn med en ...

    • Ikke-seminom germinalcellesvulster behandlet ved Universitetssykehuset i Nord-Norge 1985-2000 

      Kildahl-Andersen, Arne; Erke, Maja Gran (Master thesis; Mastergradsoppgave, 2004-06-23)

    • IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene 

      Thiyagarajan, Dhivya; Pedersen, Hege Lynum; Seredkina, Natalya; Horvei, Kjersti Daae; Arranz, Lorena; Sonneveld, Ramon; Nijenhuis, Tom; van der Vlag, Johan; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-06)
      Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytokines on expression level and nuclear localisation of DNase I and corresponding levels of Fas receptor (FasR) and IL-1β were determined by confocal microscopy, qPCR ...

    • IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction 

      Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-12)
      <p><i>Background</i>: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL-6 receptor (IL-6R)-antagonist tocilizumab on the expression of the ...

    • ‘Illuminating determinants of implementation of non-dispensing pharmacist services in home care: a qualitative interview study’ 

      Bø, Karl-Erik; Halvorsen, Kjell H.; Risør, Torsten; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-13)
      Objectives - Medication errors are leading causes of hospitalization and death in western countries and WHO encourages health care providers to implement non-dispensing pharmacist services in primary care to improve medication work. However, these services struggle to provide any impact on clinical outcomes. We wanted to explore health care professionals’ views on medication work to illuminate ...

    • ILSA 2017 in Tromsø : proceedings from the 42nd annual conference of the International Lung Sound Association 

      Melbye, Hasse (Conference object; Konferansebidrag, 2017)
      The usefulness of lung auscultation is changing. It depends on how well practitioners understand the generation of sounds. It also depends on their knowledge on how lung sounds are associated with lung and heart diseases, as well as with other factors such as ageing and smoking habits. In clinical practice, practitioners need to give sufficient attention to lung auscultation, and they should use ...

    • Imaging in plastic surgery. A clinical and experimental study with notes on the history of medical imaging. 

      Weum, Sven (Doctoral thesis; Doktorgradsavhandling, 2013-04-29)
      This thesis is based on four papers that have imaging techniques used in breast reconstruction as the common denominator. Each paper describes the results of a study. The purpose of the first three studies was to evaluate the use of dynamic infrared thermography (DIRT) as an imaging technique for perforator mapping in breast reconstruction with a deep inferior epigastric perforator (DIEP) flap. The ...

    • Immediate function on the day of surgery compared with a delayed implant loading process in the mandible: A randomized clinical trial over 5 years 

      Jokstad, Asbjørn; Alkumru, Hassan (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10-23)
      Objectives: To appraise the feasibility of loading four implants with a pre-existing denture converted to a fixed dental prosthesis (FDP) on the day of implant surgery compared with waiting for 3- to 4-month healing.<p> <p>Methods: Patients with an edentulous, fully healed mandible were recruited in a faculty clinic to partake in a blinded two-arm parallel randomized controlled trial (RCT). The ...

    • Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients 

      Yardley, Marianne; Ueland, Thor; Aukrust, Pål; Michelsen, Annika; Bjørkelund, Elisabeth; Gullestad, Lars; Nytrøen, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-28)
      <p><i>Background</i>: The present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity interval training (HIT) versus moderate-intensity continuous training (MICT). The study aimed to explain some of the trigger mechanisms behind HIT in HTx recipients.</p> ...

    • Immune Infiltration and Clinical Outcome in Non-Small Cell Lung Cancer 

      Rakaee, Mehrdad (Doctoral thesis; Doktorgradsavhandling, 2019-03-12)
      Lung cancer is the cancer responsible for the most deaths worldwide. Treatment is multimodal and based on information specific to the tumor (histology, stage, biology and genetics aberrations) and patient-related factors. During the last decade, the arrival of novel targeted therapies and immunotherapy, has led to a paradigm shift in the management of lung cancer. In this regard, assessment of tumor ...

    • The immune microenvironment in oral squamous cell carcinoma – characterization and prognostic markers 

      Wirsing, Anna Maria (Doctoral thesis; Doktorgradsavhandling, 2018-09-27)
      Oral squamous cell carcinomas (OSSCs) are aggressive tumors often associated with a low survival rate. The immune system influences the development of OSCCs, and the immune infiltrate surrounding the cancer cells is an indicator of the host’s anti-tumor response. The main aim of this thesis was to describe how the tumor microenvironment in OSCC is organized, and to determine whether different subsets ...

    • Immune properties of cry1Ab transgenic maize studied in mouse models of airway and food allergy 

      Andreassen, Monica (Doctoral thesis; Doktorgradsavhandling, 2015-03-19)
      The genetically modified maize event MON810 has been inserted with a processed version of the transgene, cry1ab, derived from the soil bacterium Bacillus thuringiensis (Bt) to express proteins with insecticidal properties. The introduced toxin may confer risks of immunogenicity, allergenicity and/or adjuvanticity to humans as well as domestic and wild animals, via inhalation of pollen and plant ...

    • Immune-modulating properties of carcinoma-associated fibroblasts and their changes during radiotherapy. In vitro study of primary non-small cell lung carcinoma-associated fibroblasts 

      Gorchs, Laia (Master thesis; Mastergradsoppgave, 2015-05-15)
      Background/aim of the study: Carcinoma-associated Fibroblasts (CAFs) comprise a heterogeneous population of cells and often represent the major cellular component of solid malignancies playing critical roles in tumor progression and metastasis. The purpose of this study was to gain more knowledge on the immunosuppressive traits of CAFs isolated from non-small cell lung carcinomas (NSCLC), and to ...

    • Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia 

      Askarian, Fatemeh; Tsai, Chih-Ming; Cordara, Gabriele; Zurich, Raymond H.; Bjånes, Elisabet; Golten, Ole; Sørensen, Henrik Vinther; Kousha, Armin; Meier, Angela; Chikwati, Elvis Mashingaidze; Bruun, Jack-Ansgar; Ludviksen, Judith K; Choudhury, Biswa; Trieu, Desmond; Davis, Stanley; Edvardsen, Per Kristian Thorén; Mollnes, Tom Eirik; Liu, George Y.; Krengel, Ute; Conrad, Douglas J.; Vaaje-Kolstad, Gustav; Nizet, Victor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)
      Pseudomonas aeruginosa (PA) CbpD belongs to the lytic polysaccharide monooxygenases (LPMOs), a family of enzymes that cleave chitin or related polysaccharides. Here, we demonstrate a virulence role of CbpD in PA pneumonia linked to impairment of host complement function and opsonophagocytic clearance. Following intratracheal challenge, a PA ΔCbpD mutant was more easily cleared and produced less ...