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Attenuated Notch signaling in schizophrenia and bipolar disorder
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-23)The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a pathway analysis. We measured plasma levels of Notch ligands (DLL1 and DLK1) using enzyme immunoassays in a large sample of patients (SCZ n = 551, BD n = 246) and healthy controls ... -
Attitudes and knowledge about direct and indirect risks among conventional and complementary health care providers in cancer care
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-31)Background: Many complementary therapies offer benefits for patients with cancer. Others may be risky for patients due to negative interactions with conventional treatment and adverse effects. Therefore, cancer patients need guidance from health care providers to assess complementary modalities appropriately to receive benefits and avoid harm. <br> Method: In a self-administered questionnaire-based ... -
Attitudes of mental health providers towards adoption of evidence-based interventions: relationship to work-place, staff roles and social and psychological factors at work
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)<p><i>Background - </i>Gaining insight into factors influencing the adoption of evidence-based interventions (EBI) is essential to ensuring their sustainability in the mental healthcare setting. This article describes 1) differences between professional staff roles in attitudes towards EBI and 2) individual and organizational predictors of attitudes towards adopting EBI. <p><i>Methods - </i>The ... -
Attitudes of Mental Health Service Users Toward Storage and Use of Electronic Health Records
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)Objective: Electronic health records (EHRs) are used for both clinical practice and research. Because mental health service users’ views are underrepresented in perspectives on EHR use, the authors examined service users’ awareness, attitudes, and opinions about EHR data storage and sharing.<p> <p>Methods: A mixed-methods, cross-sectional design was used to examine attitudes of 253 Norwegian ... -
Attitudes to evidence-based interventions and routine outcome measures in mental health professionals
(Doctoral thesis; Doktorgradsavhandling, 2019-06-20)The complicated relationship between clinical health science and clinical practice has widely been referred to as the “science-practice gap”. This is for instance visible in the discrepancy between the amount of resources spent to develop and apply evidence-based treatment programmes and interventions (EBI) and the extent to which these interventions are used in real-life mental health care service ... -
Attitudes towards mathematics, achievement, and drop-out intentions among STEM and Non-STEM students in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-22)High mathematical ability is central in many domains. In the present study, we investigated relations between students’ high school mathematics background and current study program, and various mathematics-related outcomes. We expected that students who had attended higher-level mathematics courses in high school would report more positive attitudes towards mathematics and higher achievement in ... -
Attitudes towards sickness absence and sickness presenteeism in health and care sectors in Norway and Denmark: a qualitative study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-27) -
Attitudes Towards the Use of Routine Outcome Monitoring of Psychological Therapies Among Mental Health Providers: The EBPAS–ROM
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-28)Implementation of routine outcome monitoring (ROM) in mental health care is progressing slowly. Knowledge about factors influencing ROM implementation, including health providers’ attitudes towards ROM, is necessary. Based on a survey of 662 psychologists and nurses, this article describes (1) the development of a short instrument measuring provider attitudes towards ROM, derived from the Evidence-based ... -
Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-05)<i>Background</i> - Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of ... -
Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Audiovisual recordings of breath sounds to standardize nomenclature
(Master thesis; Mastergradsoppgave, 2014-05-30)Lungeauskultasjon har historisk sett vært en viktig del av den kliniske undersøkelsen, men har manglet en felles, faglig terminologi for å beskrive funnene man har gjort. På tross av flere forsøk på forenkling av eksisterende terminologi, viser studier at det fortsatt er stor variasjon i begrepsbruken blant leger, og at det er et behov for standardisering av lungelydsterminologi. European ... -
An audit and feedback intervention study increased adherence to antibiotic prescribing guidelines at a Norwegian hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-27)Background:<br> Appropriate antibiotic prescribing is associated with favourable levels of antimicrobial resistance (AMR) and clinical outcomes. Most intervention studies on antibiotic prescribing originate from settings with high level of AMR. In a Norwegian hospital setting with low level of AMR, the literature on interventions for promoting guideline-recommended antibiotic prescribing in ... -
Autism Spectrum Disorders: Complexities associated with sex-differences, screening and diagnosis
(Doctoral thesis; Doktorgradsavhandling, 2018-06-28)The present doctoral thesis examines screening and sex differences in autism spectrum disorders (ASD), and how behavioral, developmental and temperamental features of males and females affect early identification of the disorder. The present doctoral thesis found marked sex differences across all three studies, and furthermore found evidence of difficulties at identifying all children with an ASD ... -
Autobiografiske berøringsøyeblikk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021)Autobiografiske berøringsøyeblikk. Denne artikkelen undersøker berøringens betydning i og potensiale for palliativ omsorg, sett i lys av dominansen i etisk og juridisk tenkning på bevisst livsopplevelse, autonomi og kognitiv samtykkekompetanse. Fire berøringsøyeblikk fra forfatterens biografi illustrerer at berøring er verdifull i ulike former for omsorg for personer som ikke i tilstrekkelig ... -
Autocrine Prostaglandin E-2 Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Prostaglandin E2 (PGE2) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investigated the significance of a high COX-2 expression in neuroblastoma by analysis of PGE2 production, the expression pattern ... -
Autofagi og Steroidhormoner i Kreftutvikling - et litteraturstudium
(Master thesis; Mastergradsoppgave, 2014-06-01)Autofagi og steroidhormoner er store temaer innen kreftforskning med mange ubesvarte spørsmål. Bakgrunn for oppgaven er en systematisk gjennomgang av litteratur hvor det undersøkes om steroidhormonaktivert autofagi innen kreftutvikling er sannsynlig. Innledningsvis utdypes det hva steroidhormoner er, deres rolle som signaleringssubstanser og påvirkningen på ulike fysiologiske prosesser. Videre ... -
Autofluorescence in freshly isolated adult human liver sinusoidal cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths. Autofluorescence was detected in LAMP-1 positive vesicles, suggesting lysosomal location. Confocal imaging of freshly prepared cultures and imaging flow cytometry of non-cultured cells revealed fluorescence in all channels used. Treatment ... -
Autoimmune disease and risk of postpartum venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)Background - The risk of pregnancy-related mortality in the United States has nearly doubled since 1990, with venous thromboembolism (VTE) accounting for approximately 10% of these deaths.<p> <p>Objectives - The objective of this study was to assess whether preexisting autoimmune disease is a risk factor for postpartum VTE.<p> <p>Methods - Using the MarketScan Commercial and Medicare Supplemental ... -
Autoimmunity and SLE: Factual and Semantic Evidence-Based Critical Analyses of Definitions, Etiology, and Pathogenesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)One cannot discuss anti-dsDNA antibodies and lupus nephritis without discussing the nature of Systemic lupus erythematosus (SLE). SLE is insistently described as a prototype autoimmune syndrome, with anti-dsDNA antibodies as a central biomarker and a pathogenic factor. The two entities, “SLE” and “The Anti-dsDNA Antibody,” have been linked in previous and contemporary studies although serious criticism ... -
Autolog hematopoietisk stamcelletransplantasjon (AHSCT) ved diffus systemisk sklerose
(Research report; Forskningsrapport, 2018-08-14)<p><b>Innledning</b>: Systemisk sklerose, også kalt sklerodermi, hører inn under gruppen revmatiske sykdommer, og er en sjelden autoimmun systemisk bindevevssykdom. Ved systemisk sklerose angripes bindevev i hud, blodårer og indre organer med progressiv fibrosedannelse. Autolog hematopoietisk stamcelletransplantasjon (AHSCT) har blitt foreslått for en liten gruppe pasienter med diffus systemisk ...
