Browsing Det helsevitenskapelige fakultet by Title

Now showing items 6817-6836 of 10152

    • Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies 

      Beral, V; Hermon, C; Peto, R; Reeves, G; Brinton, L; Marchbanks, P; Negri, E; Peeters, PHM; Vessey, M; Calle, EE; Gapstur, SM; Patel, AV; Dal Maso, L; Talamini, R; Chetrit, A; Hirsh-Yechezkel, G; Lubin, F; Sadetzki, S; Allen, N; Bull, D; Callaghan, K; Crossley, B; Gaitskell, K; Goodill, A; Green, J; Key, T; Moser, K; Collins, R; Doll, R; Gonzalez, CA; Lee, N; Ory, HW; Peterson, HB; Wingo, PA; Martin, N; Pardthaisong, T; Silpisornkosol, S; Theetranont, C; Boosiri, B; Chutivongse, S; Jimakorn, P; Virutamasen, P; Wongsrichanalai, C; Tjonneland, A; Titus-Ernstoff, L; Byers, T; Rohan, T; Mosgaard, BJ; Yeates, D; Freudenheim, JL; Chang-Claude, J; Kaaks, R; Anderson, KE; Folsom, A; Robien, K; Rossing, MA; Thomas, DB; Weiss, NS; Riboli, E; Clavel-Chapelon, F; Cramer, D; Hankinson, SE; Tworoger, SS; Franceschi, S; La Vecchia, C; Magnusson, C; Riman, T; Weiderpass, Elisabete; Wolk, A; Schouten, LJ; van den Brandt, PA; Chantarakul, N; Koetsawang, S; Rachawat, D; Palli, D; Black, A; de Gonzalez, AB; Freedman, DM; Hartge, P; Hsing, AW; Lacey, JV; Hoover, RN; Schairer, C; Graff-Iversen, Sidsel; Selmer, Randi; Bain, CJ; Green, AC; Purdie, DM; Siskind, V; Webb, PM; McCann, SE; Hannaford, P; Kay, C; Binns, CW; Lee, AH; Zhang, M; Ness, RB; Nasca, P; Coogan, PF; Palmer, JR; Rosenberg, L; Kelsey, J; Paffenbarger, R; Whittemore, A; Katsouyanni, K; Trichopoulou, A; Trichopoulos, D; Tzonou, A; Dabancens, A; Martinez, L; Molina, R; Salas, O; Goodman, MT; Lurie, G; Carney, ME; Wilkens, LR; Hartman, L; Manjer, J; Olsson, H; Grisso, JA; Morgan, M; Wheeler, JE; Casagrande, J; Pike, MC; Ross, RK; Wu, AH; Miller, AB; Kumle, Merethe; Lund, Eiliv; McGowan, L; Shu, XO; Zheng, W; Farley, TMM; Holck, S; Meirik, O; Risch, HA (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Individual data on 25,157 women with ovarian cancer and 81,311 women ...

    • Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies 

      Gaitskell, K; Hermon, C; Moser, K; Reeves, G; Peto, R; Brinton, L; Marchbanks, P; Negri, E; Ness, R; Peeters, PHM; Vessey, M; Calle, EE; Gapstur, SM; Patel, AV; Dal Maso, L; Talamini, R; Chetrit, A; Hirsh-Yechezkel, G; Lubin, F; Sadetzki, S; Banks, E; Beral, V; Bull, D; Callaghan, K; Crossley, B; Goodill, A; Green, J; Key, T; Sitas, F; Collins, R; Doll, R; Gonzalez, A; Lee, N; Ory, HW; Peterson, HB; Wingo, PA; Martin, N; Pardthaisong, T; Silpisornkosol, S; Theetranont, C; Boosiri, B; Chutivongse, S; Jimakorn, P; Virutamasen, P; Wongsrichanalai, C; Tjonneland, A; Titus-Ernstoff, L; Byers, T; Rohan, T; Mosgaard, BJ; Yeates, D; Freudenheim, JL; Chang-Claude, J; Kaaks, R; Anderson, KE; Folsom, A; Robien, K; Hampton, J; Newcomb, PA; Rossing, MA; Thomas, DB; Weiss, NS; Riboli, E; Clavel-Chapelon, F; Cramer, D; Hankinson, SE; Tworoger, SS; Franceschi, S; La Vecchia, C; Adami, HO; Magnusson, C; Riman, T; Weiderpass, Elisabete; Wolk, A; Schouten, LJ; van den Brandt, PA; Chantarakul, N; Koetsawang, S; Rachawat, D; Palli, D; Black, A; Brinton, LA; Freedman, DM; Hartge, P; Hsing, AW; Lacey, JV; Hoover, RN; Schairer, C; Urban, M; Graff-Iversen, Sidsel; Selmer, Randi; Bain, CJ; Green, AC; Purdie, DM; Siskind, V; Webb, PM; Moysich, K; McCann, SE; Hannaford, P; Kay, C; Binns, CW; Lee, AH; Zhang, M; Ness, RB; Nasca, P; Coogan, PF; Palmer, JR; Rosenberg, L; Kelsey, J; Paffenbarger, R; Whittemore, A; Katsouyanni, K; Trichopoulou, A; Trichopoulos, D; Tzonou, A; Dabancens, A; Martinez, L; Molina, R; Salas, O; Goodman, MT; Lurie, G; Carney, ME; Wilkens, LR; Hartman, L; Manjer, J; Olsson, H; Grisso, JA; Morgan, M; Wheeler, JE; Bunker, CH; Edwards, RP; Modugno, F; Casagrande, J; Pike, MC; Ross, RK; Wu, AH; Miller, AB; Kumle, Merethe; Gram, Inger Torhild; Lund, Eiliv; McGowan, L; Shu, XO; Zheng, W; Farley, TMM; Holck, S; Meirik, O; Risch, HA (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence. Eligible epidemiological studies were identified by electronic searches, review articles, and discussions ...

    • Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium 

      Fortner, Renée T.; Poole, Elizabeth M.; Wentzensen, Nicolas A.; Trabert, Britton; White, Emily; Arslan, Alan A.; Patel, Alpa V.; Setiawan, V. Wendy; Visvanathan, Kala; Weiderpass, Elisabete; Adami, Hans Olov; Black, Amanda; Bernstein, Leslie; Brinton, Louise A.; Buring, Julie; Clendenen, Tess V.; Fournier, Agnès; Fraser, Gary; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Gram, Inger Torhild; Hartge, Patricia; Hoffman-Bolton, Judith; Idahl, Annika; Kaaks, Rudolf; Kirsh, Victoria A.; Knutsen, Synnøve; Koh, Woon-Puay; Lacey, James V.; Lee, I-Min; Lundin, Eva; Merritt, Melissa A.; Milne, Roger L.; Onland-Moret, N. Charlotte; Peters, Ulrike; Poynter, Jenny N.; Rinaldi, Sabina; Robien, Kim; Rohan, Thomas; Sánchez, María-José; Schairer, Catherine; Schouten, Leo J.; Tjønneland, Anne; Townsend, Mary K.; Travis, Ruth C.; Trichopoulou, Antonia; van den Brandt, Piet A.; Vineis, Paolo; Wilkens, Lynne; Wolk, Alicja; Yang, Hannah P.; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-18)

    • Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women : the Norwegian EBBA-I study 

      Iversen, Anita; Thune, Inger; McTiernan, Anne; Emaus, Aina; Finstad, Sissi Espetvedt; Flote, Vidar Gordon; Wilsgaard, Tom; Lipson, Susan; Ellison, Peter T; Jasienska, Grazyna; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Ovarian hormones, parity and length of ‘menarche-to-first birth’ time interval are known risk factors for breast cancer, yet the associations between 17β-estradiol, progesterone and these reproductive factors remain unclear. A total of 204 women (25–35 years) who participated in the Norwegian EBBA-I study collected daily saliva samples for one complete menstrual cycle, and filled in a reproductive ...

    • Overall lifestyle changes in adulthood are associated with cancer incidence in the Norwegian Women and Cancer Study (NOWAC) - a prospective cohort study 

      Chen, Sairah Lai Fa; Nøst, Therese Haugdahl; Botteri, Edoardo; Ferrari, Pietro; Braaten, Tonje; Sandanger, Torkjel M; Borch, Kristin Benjaminsen (Journal article; Tidsskriftartikkel, 2023-04-03)
      <p><i>Background:</i> Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely related to cancer incidence. However, there is little knowledge on the impact of lifestyle modification within adulthood. <p><i>Methods:</i> ...

    • Overall survival and time trends in breast and cervical cancer incidence and mortality in the Regional Health District (RHD) of Barretos, Sao Paulo, Brazil 

      Da Costa, Allini Mafra; Hashim, Dana; Fregnani, Jose Humberto; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)
      <p><i>Background</i>: Breast and cervical cancers represent a significant cause of morbidity and mortality among women. The purpose of this study was to analyse the survival and time trends in two of the most common female cancers in the Regional Health District (RHD) of Barretos, São Paulo, Brazil.</p> <p><i>Methods</i>: From 2000 through 2015, we calculated the breast and cervical cancer incidence ...

    • Overdiagnosis in screening mammography in Denmark: population based cohort study 

      Njor, Sissel Helle; Olsen, Anne Helene; Blichert-Toft, Mogens; Schwartz, Walter; Vejborg, Ilse; Lynge, Elsebeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-02-26)
      Objective To use data from two longstanding, population based screening programmes to study overdiagnosis in screening mammography.<p> <p>Design Population based cohort study. <p>Setting Copenhagen municipality (from 1991) and Funen County (from 1993), Denmark. <p>Participants 57 763 women targeted by organised screening, aged 56-69 when the screening programmes started, and followed up to ...

    • Overdiagnosis of breast cancer in the Norwegian Breast Cancer Screening Program estimated by the Norwegian Women and Cancer cohort study 

      Lund, Eiliv; Mode, Nicolle; Waaseth, Marit; Thalabard, Jean-Christophe (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifetime outside screening. This analysis compares the cumulative incidence of breast cancer in screened and unscreened women in Norway from the start of the fully implemented Norwegian ...

    • Overdiagnosis – exemplified with mammographic screening 

      Hofvind, Solveig Sand-Hanssen; Mangerud, Gunhild; Holen, åsne Sørlien; Ursin, Giske (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-12)
      Hovedmålsettingen med organisert mammografiscreening er å oppdage brystkreft i et tidlig stadium og dermed redusere sykelighet og dødelighet av sykdommen. En ulempe er overdiagnostikk. Verdens helseorganisasjons kreftforskningsinstitutt definerer overdiagnostikk i mammografiscreening som brystkreft som ikke ville blitt diagnostisert i kvinnens levetid dersom hun ikke hadde deltatt i screening. Vi ...

    • Overexpression of miR-20a-5p in Tumor Epithelium Is an Independent Negative Prognostic Indicator in Prostate Cancer — A Multi-Institutional Study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Donnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Busund, Lill-Tove R.; Richardsen, Elin (Master thesis; Mastergradsoppgave; Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-26)
      <p><i>Background:</i> MicroRNAs (miRs) have critical regulatory roles in cell functions, and are involved in prostate cancer tumorigenesis. miR-20a-5p is a member of the oncogenic miR-17-92 cluster. Overexpressed miR-20a-5p has been shown to increase both cell proliferation and cell migration in cancers. The aim of our cohort study was to evaluate the prognostic role of miR-20a-5p in prostate cancer. ...

    • Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Dønnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-14)
      <i>Objective</i>: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study.<br><br> <i>Methods</i>: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. In situ hybridization was performed to assess the expression level of miR-20a-5p in different tissue subregions: tumor stroma (TS) and tumor epithelium (TE). ...

    • Overexpression of NOX2 Exacerbates AngII‐Mediated Cardiac Dysfunction and Metabolic Remodelling 

      Hansen, Synne; Pedersen, Tina Myhre; Marin, Julie; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen; Hafstad, Anne Dragøy (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)
      The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte specific upregulation of NOX2 (csNOX2 TG). Mice were treated with saline (sham), 50 or 400 ng/kg/min of AngII (AngII50 and AngII400) for two weeks. In ...

    • Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival 

      Andersen, Sigve; Dønnem, Tom; Stenvold, Helge; Al-Saad, Samer; Al-Shibli, Khalid Ibrahim; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC. Tumor tissue samples from 335 resected stages I to IIIA NSCLC patients was obtained and tissue ...

    • Overføring av lungekreftpasienter i palliativ fase fra spesialisthelsetjeneste til primærhelsetjeneste – hvilke erfaringer har sykepleiere i kommunene? - En kvalitativ studie 

      Wilhelmsen, Rune (Master thesis; Mastergradsoppgave, 2023-08-30)
      Sammendrag Bakgrunn: Kvalitativ forskning som fokuserer på samhandling mellom spesialist- og primærhelsetjenesten viser at det er manglende utveksling av informasjon mellom tjenestenivåene, at ansvarsfordelingen er uklar og at helsepersonell mangler kunnskap om organisering av tjenestene hos aktørene de samhandler med. Forskning som undersøker samhandlingsreformens konsekvenser, viser at ...

    • Overgrepsutsattes erfaringer med spesialiserte lavterskeltilbud Symbolsk anerkjennelse, solidariske fellesskap 

      Østby, Lene; Stefansen, Kari; Smette, Ingrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-02)
      Et godt utbygd hjelpetilbud til overgrepsutsatte regnes i dag som et åpenbart samfunnsansvar. De ulike tiltakene som finnes, utgjør til sammen et komplekst tjenestelandskap. Denne artikkelen handler om spesialiserte lavterskeltilbud i frivillig sektor, sentre mot incest og seksuelle overgrep. I artikkelen undersøker vi hva overgrepsutsatte selv framhever som viktig og positivt ved sentrene med tanke ...

    • Overlevelse etter pankreasreseksjoner ved Universitetssykehuset i Nord-Norge (UNN Tromsø) 

      Heimdal, Emilie Anne (Master thesis; Mastergradsoppgave, 2023-08-17)
      Bakgrunn Pankreaskirurgi er i Norge sentralisert til fem regionale sentre. Mellom 2006-2016 fikk 260 pasienter utført pankreatoduodenektomi (PD), distal halereseksjon (DPR) eller total pankreatektomi (TP) i Tromsø, det nordligste senteret i Norge. Indikasjoner for reseksjon er symptomatiske lesjoner, maligne lesjoner, eller lesjoner med malignitetspotensiale. Nasjonale og internasjonale data viser ...

    • Overlevelse hos pasienter med spiserørskreft behandlet ved Kreftavdelingen i perioden år 2000-2010 

      Helgesen, Kristine Løkse (Master thesis; Mastergradsoppgave, 2011-09-15)
      Spiserørskreft er en sykdom med dårlig prognose. Tidligere var kurativ behandling av spiserørskreft kirurgi alene, eventuelt neoadjuvant(preoperativ) strålebehandling og etterfulgt av kirurgi ved lokalavansert sykdom. De siste 20 til 30 årene har man prøvd å bedre behandlingsresultatene ved å introdusere radiokjemoterapi (kjemoterapi og stråling) før kirurgi. Fra 2002 startet kreftavdelingen ved UNN ...

    • Overlevelse ved akutt lymfatisk leukemi hos barn og betydning av tidlig oppdagelse av tilbakefall etter avsluttet behandling 

      Brekke, Lill-Tone Heitmann (Master thesis; Mastergradsoppgave, 2018-08-01)
      Innledning. Akutt lymfatisk leukemi (ALL) er den vanligst forekommende kreftsykdommen hos barn. Norge deltar i det nordiske samarbeidet, med felles registrering og behandling av barn med ALL. Samarbeidet har ført til økt overlevelse av ALL hos barn de siste tiårene, men prognosen etter residiv er fremdeles dårlig. Rutinekontroller etter endt terapi har som mål å oppdage residiv tidlig, for å raskt ...

    • Oversettelse og kulturell tilpasning av Attentional Function Index (AFI) 

      Utne, Inger; Grov, Ellen Karine; Kjerland, Linn Elise; Rønning, Mette; Rodrigues-Aranda, Claudia; Rasmussen, Hege Lund; Løyland, Borghild (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-22)
      Bakgrunn:<br>Antall krefttilfeller blant eldre øker sterkt, og i forbindelse med behandlingen kan kreftpasienter være utsatt for kognitive endringer. Mange av dem som overlever kreft, får nedsatt oppmerksomhet og konsentrasjon samt dårligere hukommelse. Attentional Function Index (AFI) er et instrument for å kartlegge kognitive prosesser, og det er utviklet i USA.<br>Hensikt:<br>Å redegjøre for ...

    • Oversettelse og psykometrisk testing av The Family Collaboration Scale 

      Moholt, Jill-Marit; Hanssen, Tove Aminda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-15)
      Bakgrunn: <br>Instrumentet The Family Collaboration Scale (FCS) er utviklet for å undersøke pårørendes opplevelser rundt samarbeid med pleiepersonalet når svekkete eldre er akutt innlagt i sykehus. <br>Hensikt: <br>Studiens hensikt var å oversette FCS fra dansk til norsk. Vi ønsket også å teste de måletekniske egenskapene til den oversatte versjonen på et utvalg pårørende til svekkete eldre ...