The synthesis, cytotoxicity, inhibition of tubulin polymerization and anti-angiogenic effects of 10 analogs of 2-methoxyestradiol are reported. These efforts revealed that the analog with a 4-pyridine ring in the 17-position, in combination with 2-ethyl- and 3-sulfamate substituents on the steroid A-ring, is the most interesting anti-cancer agent. This compound showed potent inhibitory effects against ...

Enzymes of the M4 family of zinc-metalloproteinases are virulence factors secreted from gram-positive or gram-negative bacteria, and putative drug targets in the treatment of bacterial infections. In order to have a therapeutic value such inhibitors should not interfere with endogenous zinc-metalloproteinases. In the present study we have synthesised a series of hydroxamate derivatives and validated ...

The global spread of antimicrobial resistance and the increasing number of immune‐compromised patients are major challenges in modern medicine. Targeting bacterial virulence or the human host immune system to increase host defence are important strategies in the search for novel antimicrobial drugs. We investigated the inflammatory response of the synthetic short antimicrobial peptide LTX21 in two ...

The primary aim of this study is to summarise research findings about the use of assessment frameworks, that is, structured models that guide information collection and decision making in child protection services, by reviewing the literature. The research review method consisted of identification, selection, coding, categorisation and summary of publications on child protection investigative work. ...

We investigated whether a novel visitation model for school-aged youth with mental health problems based on a stage-based stepped-care approach facilitated a systematic identification and stratification process without problems with equity in access. The visitation model was developed within the context of evaluating a new transdiagnostic early treatment for youth with anxiety, depressive symptoms, ...

Storulykker er krevende for prehospitale medisinske tjenester over hele verden. Vi vet at de samme problemene viser seg gang på gang. Hvordan kan de prehospitale tjenestene lære av tidligere erfaringer? På grunn av storulykkers (engelsk: major incidents) omfattende betydning for menneskeliv og samfunn er det nødvendig å standardisere rapporteringen fra hendelsene. Dette kan muliggjøre analyser ...

Introduction: Diarrhea-predominant irritable bowel syndrome (IBS-D) significantly decreases the quality of life of patients and their families, and affects patients’ mental health. No specific western medications are available. Ancient classical Chinese medical texts have recognized Tongxie Yaofang (TXYF) as a therapy for diarrhea which is widely used in clinical practice. Standard TXYF prescription ...

<p><i>Objective</i> There is an increasing incidence of testicular cancer in the world, which cannot be explained by factors as increasing life expectancy as this type of cancer typically affects young men. Particularly in certain countries that also score high on the Human Development Index (HDI) the incidence of testicular cancer is high, and as countries increase the HDI so does the incidence of ...

<p><i>Background</i>: Dental implants are available in different shapes.</p> <p><i>Aims</i>: This systematic review aims to address whether tapered compared to non‐tapered implants demonstrate similar clinical and patient‐reported outcomes. The review follows the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) format.</p> <p><i>Materials & Methods</i>: We searched ...

Objectives: The present review investigated whether there are systematic sex differences in the placebo and the nocebo effect. <br>Methods: A literature search was conducted in multiple electronic databases. Studies were included if the study compared a group or condition where a placebo was administered to a natural history group or similar cohort. <br>Results: Eighteen studies were identified ...