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    • Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline 

      Enoksen, Inger Therese Tønsberg; Rinde, Nikoline Balteskard; Svistounov, Dmitri; Norvik, Jon Viljar Porserud; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08)
      Significance Statement - eGFR from creatinine, cystatin C, or both has been primarily used in search of biomarkers for GFR decline. Whether the relationships between biomarkers and eGFR decline are similar to associations with measured GFR (mGFR) decline has not been investigated. This study revealed that some biomarkers showed statistically significant different associations with eGFR decline ...

    • Validation of forearm fracture diagnoses in administrative patient registers 

      Omsland, Tone Kristin; Solberg, Lene Bergendal; Bjørnerem, Åshild Marit; Borgen, Tove Tveitan; Andreasen, Camilla; Wisløff, Torbjørn; Hagen, Gunhild; Basso, Trude; Gjertsen, Jan-Erik; Apalset, Ellen Margrete; Figved, Wender; Stutzer, Jens-Meinhard; Nissen, Frida Igland; Hansen, Ann Kristin; Joakimsen, Ragnar Martin; Figari, Elisa; Peel, Geoffrey; Rashid, Ali A.; Khoshkhabari, Jashar; Eriksen, Erik Fink; Nordsletten, Lars; Frihagen, Frede; Dahl, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to defne forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ...

    • Validation of forearm fracture diagnoses in administrative patient registers 

      Omsland, Tone Kristin; Solberg, Lene Bergendal; Bjørnerem, Åshild Marit; Borgen, Tove Tveitan; Andreasen, Camilla; Wisløff, Torbjørn; Hagen, Gunhild; Basso, Trude; Gjertsen, Jan-Erik; Apalset, Ellen Margrete; Figved, Wender; Stutzer, Jens-Meinhard; Nissen, Frida Igland; Hansen, Ann Kristin; Joakimsen, Ragnar Martin; Figari, Elisa; Peel, Geoffrey; Rashid, Ali A.; Khoshkhabari, Jashar; Eriksen, Erik Fink; Nordsletten, Lars; Frihagen, Frede; Dahl, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)
      Summary The validity of forearm fracture diagnoses recorded in fve Norwegian hospitals was investigated using image reports and medical records as gold standard. A relatively high completeness and correctness of the diagnoses was found. Algorithms used to define forearm fractures in administrative data should depend on study purpose.<p> <p>Purpose In Norway, forearm fractures are routinely recorded ...

    • Validation of repeated self-reported n-3 PUFA intake using serum phospholipid fatty acids as a biomarker in breast cancer patients during treatment 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 

      Brunvoll, Sonja Hjellegjerde; Thune, Inger; Frydenberg, Hanne; Flote, Vidar Gordon; Bertheussen, Gro Falkener; Schlichting, Ellen; Bjerve, Kristian S; Hjartåker, Anette (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <p><i>Background</i>: The role of n-3 polyunsaturated fatty acids (PUFAs) in breast cancer is not clear and under debate. To explore this relationship it is important to have proper validated dietary assessment methods for measuring the intake of n-3 PUFAs. The aim of the current study is to validate two different methods used to assess the intake of selected n-3 PUFAs as well as food sources of ...

    • Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort 

      Wirsing, Anna Maria; Bjerkli, Inger-Heidi; Steigen, Sonja Eriksson; Rikardsen, Oddveig G; Norvoll Magnussen, Synnøve; Hegge, Beate; Seppola, Marit; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-14)
      The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral ...

    • Validation of self-reported and hospital-diagnosed atrial fibrillation: The HUNT study 

      Malmo, Vegard; Langhammer, Arnulf; Bønaa, Kaare; Loennechen, Jan Pål; Ellekjær, Hanne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-11)
      Background: Self-reported atrial fibrillation (AF) and diagnoses from hospital registers are often used to identify persons with AF. The objective of this study was to validate self-reported AF and hospital discharge diagnoses of AF among participants in a population-based study. Materials and methods: Among 50,805 persons who participated in the third survey of the HUNT Study (HUNT3), 16,247 ...

    • Validation of sick leave measures: self-reported sick leave and sickness benefit data from a Danish national register compared to multiple workplace-registered sick leave spells in a Danish municipality 

      Stapelfeldt, Christina Malmose; Jensen, Chris; Andersen, Niels Trolle; Fleten, Nils; Nielsen, Claus Vinther (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Previous validation studies of sick leave measures have focused on self-reports. Register-based sick leave data are considered to be valid; however methodological problems may be associated with such data. A Danish national register on sickness benefit (DREAM) has been widely used in sick leave research. On the basis of sick leave records from 3,554 and 2,311 eldercare workers in 14 different ...

    • Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA) 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-13)
      <i>Purpose</i> - The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan).<p><p> <i>Patients and Methods</i> - This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain ...

    • Validation of the graded prognostic assessment for lung cancer with brain metastases using molecular markers(lung-molGPA) 

      Nieder, Carsten; Hintz, Mandy; Oehlke, Oliver; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-26)
      Background:<br>Many patients with brain metastases from non-small cell lung cancer have limited survival, while others survive for several years, depending on patterns of spread, EGFR and ALK alterations, among others. The purpose of this study was to validate a new prognostic model (Lung-molGPA) originally derived from a North American database.<br>Patients and methods:<br>This retrospective study ...

    • Validation of the multiple sclerosis diagnosis in the Norwegian Patient Registry 

      Benjaminsen, Espen; Myhr, Kjell-Morten; Grytten, Nina; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-04)
      <i>Background</i> - Health registries may yield important data for epidemiological studies. However, in order to be a valuable source for information, the registered data have to be correct.<p><p> <i>Objectives</i> - The aim of the study was to validate data from the Norwegian Patient Registry (NPR) regarding multiple sclerosis (MS).<p><p> <i>Materials and Methods</i> - We obtained data ...

    • Validation of the Norwegian version of the 10-item version of Clinical Outcomes in Routine Evaluations Outcome Measure (CORE-10) in a Norwegian adolescent population (aged 14-18). 

      Solem, Kenth Moland; Moen, Connie Malen (Master thesis; Mastergradsoppgave, 2015-04-30)
      Background: This study examined whether the 10 item version of Clinical Outcomes in Routine Evaluations Outcome Measure (CORE-10) can be used in the Norwegian adolescent population aged 14 to 18 years. The target population was 531 adolescents attending junior and senior high school, 56 adolescent outpatients from Division of Child and Adolescent Mental Health (DCAMH), and 182 adolescents utilizing ...

    • Validation of two different methods to determine cardiac ventricular dimensions in rats during experimental hypothermia 

      Tveita, Ingrid Aune (Master thesis; Mastergradsoppgave, 2012-08-03)
      Bakgrunn Prosjektet kom i gang som en forstudie til en større studie der vi ønsker å undersøke varighet og nivå av terapeutisk hypotermi som hjerneprotektiv behandling av asfyktiske, nyfødte små forsøksdyr.I slike forsøksprotokoller er det ønskelig å ha en ikke-invasiv metode for måling av hjertefunksjon, spesielt under nedkjøling, for å vurdere sirkulatorisk toleranse/overlevelse i små forsøksdyr. ...

    • Validering av Cirrus HD-OCT modell 4000 ved Nevrokirurgi-, øre-nese-hals- og øyeavdeling, UNN Tromsø 

      Aamot, Anna-Birgitte Gaup (Master thesis; Mastergradsoppgave, 2014-06-01)
      Bakgrunn: Optisk koherens tomografi (OCT) har innenfor øyefaget utviklet seg til å bli et viktig diagnostisk verktøy siden begynnelsen av 1990-tallet. I dag brukes teknikken for å diagnostisere og monitorere sykdomsutvikling samt effekt av behandling av flere øyesykdommer, som for eksempel diabetes retinopati og aldersrelatert macula degenerasjon. OCT instrumentene benytter automatiserte software ...

    • Validering av den norske foreldreversjonen av Developmental Behavior Checklist (DBC-P) 

      Halvorsen, Marianne Berg; Kaiser, Sabine; Hansen, Ida Lyngaard; Sandal, Ida Rakel Blichfeldt; Helverschou, Sissel Berge (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-11)
      This study examined the psychometric properties of the Norwegian version of the Developmental Behavior Checklist – Parent (DBC-P) in an intellectual and developmental disabilities (IDD) sample of children and adolescents (N = 168). Internal consistency was adequate to excellent for all scales (Cronbach’s alpha ranged between .70–.96). The DBC-P showed meaningful overlap with and differentiation from ...

    • Validering av migrenespørsmål i spørreskjema 

      Stensland Bugge, Nora (Master thesis; Mastergradsoppgave, 2020-08-31)
      Bakgrunn Migrene er en utbredt tilstand i den norske befolkningen, og er nesten dobbelt så vanlig hos kvinner som hos menn. Det finnes ingen diagnostisk test for migrene, hvilket kompliserer fastsettelsen av diagnosen. International Headache Society har presentert et sett med diagnostiske kriterier, hvor diagnostisk gullstandard for diagnosen migrene regnes som applikasjon av disse kriteriene i ...

    • Validering av selvrapportert legemiddelbruk hos deltakere med koronarsykdom i Tromsøundersøkelsen 

      Truong, Kieu Nhi Lise (Mastergradsoppgave; Master thesis, 2020-05-14)
      Bakgrunn: Hjerte- og karsykdommer er en fellesbetegnelse for sykdommer som involverer hjerte og blodårer. Det er en ledende årsak til død over hele verden. Flere epidemiologiske studier utføres for å undersøke årsakene til den økte sykdomsbelastningen. Ved å studere befolkningens mønster av legemiddelbruk og videre korrigere for feilbruk, kan vi redusere risikoen for nye hendelser og progresjon av ...

    • Validering av trombolysebehandlingen ved slagenhetene UNN-­Tromsø og UNN‐Harstad : en gjennomgang av pasienter med akutt hjerneslag i tidsrommet 01.01.- 31.12. 2011. 

      Pettersen, Michelle Tuv (Master thesis; Mastergradsoppgave, 2013-05-30)
      Bakgrunn: Hjerneslag er en av våre alvorligste folkesykdommer, den tredje hyppigste døds-årsak og en dominerende årsak til alvorlig funksjonshemming. Intravenøs (i.v) trombolytisk behandling med vevsplasminogen aktivator (tPA) gitt innen 4 ½ timer etter symptomdebut reduserer alvorlig funksjonshemming hos selekterte pasienter med iskemisk hjerneslag. Behandlingen øker imidlertid risikoen for død ...

    • Validering og bruk av et verktøy for å vurdere kvalitet i sekundærprofylaktisk behandling ved hjerte- kar sykdom 

      Skare, Erik Eidem (Master thesis; Mastergradsoppgave, 2009-06)
      Bakgrunn: Masteroppgaven er en del av et doktorgradsprosjekt for utvikling av en klinisk farmasøytisk service for pasienter med etablert CHD. Legemiddelrelaterte problemer kan gi økte kostnader og redusert klinisk effekt av medisinsk behandling, og gode verktøy for vurdering av kvalitet i legemiddelbehandling er mangelvare. Forekomsten av CHD er økende i den vestlige verden, og en økende andel av ...

    • Validiteten av selv-rapporterte opplysninger om hypertensjon og proteinuri i svangerskap hos kvinner i Tromsøundersøkelsen 4 

      Falkegård, Marit (Master thesis; Mastergradsoppgave, 2013-06-02)
      Formål: Validering av selv-rapporterte svangerskapsopplysninger fra Tromsø 4. Bakgrunn: Oppgaven er en del av forskningsprosjektet «Forskjeller i risikofaktorer for koronar hjertesykdom hos kvinner med tidligere svangerskapsforgiftning som har ulikt utfall ved koronar angiografi» ved Kvinneklinikken, Universitetssykehuset Nord-Norge (UNN). Hypertensive svangerskapslidelser affiserer årlig 8-10 % ...

    • Validity and responsiveness of EQ-5D-5L and SF-6D in patients with health complaints attributed to their amalgam fillings: a prospective cohort study of patients undergoing amalgam removal 

      Lamu, Admassu N.; Björkman, Lars; Hamre, Harald Johan; Alræk, Terje; Musial, Frauke; Robberstad, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-17)
      <i>Background</i> - Evidence of health utility changes in patients who suffer from longstanding health complaints attributed to dental amalgam fillings are limited. The change in health utility outcomes enables calculating quality-adjusted life-year (QALY) and facilitates the comparison with other health conditions. The purpose of this study was to estimate the validity and responsiveness of the ...