Blar i forfatter Det helsevitenskapelige fakultet "Behrens, Carsten"

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    • High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats 

      Øie, Cristina Ionica; Roepstorff, Kirstine; Behrens, Carsten; Bøggild Kristensen, Jesper; Karpf, Ditte Maria; Bolt, Gert; Gudme, Charlotte N.; Kjalke, Marianne; Smedsrød, Bård; Appa, Rupa Shree (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-05)
      Background: Von Willebrand factor (VWF) stabilizes factor VIII in the circulation and prevents its premature clearance.<p><p> Objective: To study the effects of VWF on FVIII clearance in rats with endogenous VWF.<p><p> Methods: Anatomical and hepatocellular distribution studies were performed in rats following intravenous administration of glycoiodinated recombinant FVIII (rFVIII) and a ...