Blar i forfatter Det helsevitenskapelige fakultet "Brust, Peter"

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    • Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation 

      Lai, Thu Hang; Schröder, Susann; Toussaint, Magali; Dukić-Stefanović, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jörg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rareş-Petru (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

    • PET imaging of the adenosine A2A receptor in the rotenone-based mouse model of Parkinson’s disease with [18F]FESCH synthesized by a simplified two-step one-pot radiolabeling strategy 

      Schröder, Susann; Lai, Thu Hang; Toussaint, Magali; Kranz, Mathias; Chovsepian, Alexandra; Shang, Qi; Dukić-Stefanović, Sladjana; Deuther-Conrad, Winnie; Teodoro, Rodrigo; Wenzel, Barbara; Moldovan, Rareş-Petru; Pan-Montojo, Francisco; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A<sub>2A</sub>R availability has been found in the human striatum at early stages of PD and in patients with PD and dyskinesias. The aim of this small animal positron emission tomography/magnetic resonance (PET/MR) imaging ...

    • Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography 

      Ritawidya, Rien; Wenzel, Barbara; Teodoro, Rodrigo; Toussaint, Magali; Kranz, Mathias; Deuther-Conrad, Winnie; Dukić-Stefanović, Sladjana; Ludwig, Friedrich-Alexander; Scheunemann, Matthias; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)
      A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ...

    • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

      Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...

    • Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor 

      Lai, Thu Hang; Toussaint, Magali; Teodoro, Rodrigo; Dukić-Stefanović, Sladjana; Kranz, Mathias; Deuther-Conrad, Winnie; Moldovan, Rareş-Petru; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A<sub>2A</sub>R-tailored therapy. Aiming at the development of a PET radiotracer, we herein ...