Blar i forfatter Det helsevitenskapelige fakultet "Cavalli, Andrea"

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    • Exploring Conformational Dynamics of the Extracellular Venus flytrap Domain of the GABA B Receptor: A Path-Metadynamics Study 

      Evenseth, Linn; Ocello, Riccardo; Gabrielsen, Mari; Masetti, Matteo; Recanatini, Maurizio; Sylte, Ingebrigt; Cavalli, Andrea (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-01)
      γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS). Dysfunctional GABAergic neurotransmission is associated with numerous neurological and neuropsychiatric disorders. The GABA<sub>B</sub> receptor (GABA<sub>B</sub>-R) is a heterodimeric class C G protein-coupled receptor (GPCR) comprised of GABA<sub>B1a/b</sub> and GABA<sub>B2</sub> subunits. The ...