Blar i forfatter Det helsevitenskapelige fakultet "Dumitriu, Giania Aurica"

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    • Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation. 

      Shiryaev, Alexey; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Classical mammalian mitogen-activated protein kinase (MAPK) pathways consist of a cascade of three successive phosphorylation events resulting in the phosphorylation of a variety of substrates, including another class of protein kinases referred to as MAPK-activating protein kinases (MAPKAPKs). The MAPKAPKs MK2, MK3 and MK5 are closely related, but MK2 and MK3 are the major downstream targets of the ...

    • Septin 8 is an interaction partner and in vitro substrate of MK5. 

      Shiryaev, Alexey; Kostenko, Sergiy Viktorovich; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      To identify novel substrates for the mitogen-activated protein kinase-activated protein kinase 5 (MK5). Yeast two-hybrid screening with MK5 as bait was used to identify novel possible interaction partners. The binding of putative partner was further examined by glutathione S-transferase (GST) pull-down, co-immunoprecipitation and fluorescence resonance energy transfer (FRET) analysis. In vitro kinase ...

    • Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. 

      Kostenko, Sergiy Viktorovich; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 ...