Blar i forfatter Det helsevitenskapelige fakultet "Haugen, Pål"

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    • Antibiotic use Human consumption patterns and effect on bacteria 

      Haugen, Pål (Doctoral thesis; Doktorgradsavhandling, 2015-03-17)
      Prescriptions of antibiotics in Norway, and the effect of antibiotics on bacteria were investigated. The aim was to describe the consumption of antibiotics through prescriptions to patients and address how antibiotics can favour bacterial resistance. Several methods were applied, multivariate statistics, quantile regression and mathematical modelling of experimental conditions aided in the investigations. ...

    • Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. 

      Haugen, Pål; Simonsen, Gunnar Skov; Primicerio, Raul; Furberg, Anne-Sofie; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)
      High antibiotic consumption rates are associated to high prevalence of antimicrobial resistance. Geographical differences in dispensing rates of antibiotics are frequently analysed using statistical methods addressing the central tendency of the data. Yet, examining extreme quantiles may be of equal or greater interest if the problem relates to the extremes of consumption rates, as is the case for ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...