Blar i forfatter Det helsevitenskapelige fakultet "Ibrahim, Mohd"

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    • pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function 

      Philipp, Julian; Dabkowska, Aleksandra; Reiser, Anita; Frank, Kilian; Krzysztoń, Rafał; Brummer, Christiane; Nickel, Bert; Blanchet, Clement E.; Sudarsan, Akhil; Ibrahim, Mohd; Johansson, Svante; Skantze, Pia; Skantze, Urban; Östman, Sofia; Johansson, Marie; Henderson, Neil; Elvevold, Kjetil; Smedsrød, Bård; Schwierz, Nadine; Lindfors, Lennart; Rädler, Joachim O. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-06)
      Lipid nanoparticles (LNPs) are advanced core-shell particles for messenger RNA (mRNA) based therapies that are made of polyethylene glycol (PEG) lipid, distearoylphosphatidylcholine (DSPC), cationic ionizable lipid (CIL), cholesterol (chol), and mRNA. Yet the mechanism of pH-dependent response that is believed to cause endosomal release of LNPs is not well understood. Here, we show that eGFP (enhanced ...