Blar i forfatter Det helsevitenskapelige fakultet "Kuncic, Zdenka"

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    • Opportunities and Challenges for Nanotherapeutics for the Aging Population 

      Hunt, Nicholas J; McCourt, Peter Anthony; Kuncic, Zdenka; Le Couteur, David G; Cogger, Victoria C (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Nanotherapeutics utilize the properties of nanomaterials to alter the pharmacology of the drugs and therapies being transported, leading to changes in their biological disposition (absorption, distribution, cellular uptake, metabolism and elimination) and ultimately, their pharmacological effect. This provides an opportunity to optimize the pharmacology of drugs, particularly for those that are ...

    • Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice 

      Hunt, Nick; Lockwood, Glen P; Kang, Sun Woo; Westwood, Lara; Limantoro, Christina; Chrzanowski, Wojciech; McCourt, Peter Anthony; Kuncic, Zdenka; Le Couteur, David G; Cogger, V.C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)
      Orally administered Ag<sub>2</sub>S quantum dots (QDs) rapidly cross the small intestine and are taken up by the liver. Metformin and nicotinamide mononucleotide (NMN) target metabolic and aging processes within the liver. This study examined the pharmacology and toxicology of QD-based nanomedicines as carriers of metformin and NMN in young and old mice, determining if their therapeutic potency and ...