Blar i forfatter Det helsevitenskapelige fakultet "Larsson, Rolf"

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    • Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Zachariadis, Vasilios; Cavelier, Lucia; Dahlberg, Johan; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Overnäs, Elin; Abrahamsson, Jonas; Flægstad, Trond; Heyman, Mats M.; Jónsson, Ólafur G.; Kanerva, Jukka; Larsson, Rolf; Palle, Josefine; Schmiegelow, Kjeld; Gustafsson, Mats G.; Lönnerholm, Gudmar; Forestier, Erik; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)
      Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ...

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...