Browsing Det helsevitenskapelige fakultet by Author "Rønning, Leif Reidar Brenk"

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    • Combined Therapy With Dobutamine and Omecamtiv Mecarbil in Pigs With Ischemic Acute Heart Failure Is Attributed to the Effect of Dobutamine 

      Rødland, Lars; Rønning, Leif Reidar Brenk; Kildal, Anders Benjamin; Myrmel, Truls; How, Ole-Jakob (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-23)
      Inotropic support in ischemic acute heart failure (AHF) is controversial. We tested a therapeutic principle for AHF by combining a low dose of omecamtiv mecarbil (OM; 0.25 mg/kg bolus plus 0.25 mg/kg/h) with a low dose of dobutamine (Dobut; 1.25 µg/kg/min). In 10 pigs subjected to myocardial ischemia by left coronary microembolization, this cotreatment increased cardiac power (CP) from 0.48 ± 0.14 ...