Browsing Det helsevitenskapelige fakultet by Author "Yang, Nannan"

Now showing items 1-6 of 6

    • The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers 

      Andriukaitiene, Laura; Song, Xiaobo; Yang, Nannan; Lippo V. J., Lassila; K. Vallittu, Pekka; Kerosuo, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <p><i>Background</i>: The aim of the study was to assess bacterial sealability and bonding ability of methacrylate-based Resilon (RS, SybronEndo), Endo Rez (ER, Ultradent Products Inc), and epoxy-based AH Plus (AH, Dentsply/DeTrey), MTA Fill Apex (MTAF, Angelus Soluções Odontológicas) root canal sealers, and the effect of the smear layer removal on the sealability.</p> <p><i>Methods</i>: One ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over natural killer cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over NK cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells 

      Eike, Liv-Marie; Yang, Nannan; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-13)
      Host defense peptides (HDPs) are naturally occurring molecules found in most species, in which they play a significant role in the first line defense against intruding pathogens, and several HDPs have been shown to possess anticancer activity. Structure-activity relationship studies on the HDP bovine lactoferricin revealed a de novo design of a nonamer peptide LTX-315, with oncolytic properties. In ...

    • Radiation-induced effects on TGF-beta and PDGF receptor signaling in cancer-associated fibroblasts 

      Yang, Nannan; Hellevik, Turid; Berzaghi, Rodrigo; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-15)
      Background - Cancer-associated fibroblasts (CAFs) consist of heterogeneous connective tissue cells and are often constituting the most abundant cell type in the tumor stroma. Radiation effects on tumor stromal components like CAFs in the context of radiation treatment is not well-described.<p> <p>Aim - This study explores potential changes induced by ionizing radiation (IR) on platelet-derived ...

    • The relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determines their cytotoxicity 

      Rekdal, Øystein; Haug, Bengt Erik; Kalaaji, manar; Hunter, Howard N.; Lindin, Inger; Israelsson, Ingrid; Solstad, Terese; Yang, Nannan; Brandl, Martin; Mantzilas, Dimitrios; Vogel, Hans J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-11-04)
      Background: Tryptophan side chains can influence the binding of amphipathic peptides to biological membranes. <p>Results: The cytotoxic activity of model helical amphipathic peptides was markedly influenced by the positions of tryptophan residues in the sequence. <p>Conclusion: Tryptophan residues located adjacent to a hydrophobic helical portion created the most potent cytotoxic peptides. <p> ...