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Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-04)
Background:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide ...
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-02)
Background:<br>Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.<br>Methods:<br>A nested ...
Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-07)
Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
<br>Methods: Over half a million ...
Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed; Preprint; Manuskript, 2017-07-01)
Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective ...