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Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be
involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective
studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting
results.<br>
Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the
Ovarian Cancer ...
Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive ...