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Osteoprotegerin and breast cancer risk by hormone receptor subtype: A nested case-control study in the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-08)
Background:<br>Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study.<br>Methods:<br>A case-control ...
Circulating RANKL and RANKL/OPG and breast cancer risk by ER and PR subtype: Results from the EPIC cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-31)
Receptor activator of nuclear factor-kappa B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has ...
Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
Background:
Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women,
limiting their utility for screening.
<br>Methods:
We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers
among controls (
n
= 1910) from a nested case-control study in the European Prospective Investigation into
Cancer and Nutrition ...
Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-10)
Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine ...
Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-19)
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-05)
The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival.
Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. ...
Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)
<i>Background</i>
- Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p>
<i>Methods</i>
- We developed and validated ...
An epidemiologic risk prediction model for ovarian cancer in Europe: The EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)
Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify
women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents.<p>
<p>Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European ...
Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background
The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain.
Methods
Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term ...